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- W1975186840 abstract "The present study investigated the effect of the administration of the GABA B receptor antagonists, SCH 50911 [(2 S )(+)-5,5-dimethyl-2-morpholineacetic acid], CGP 46381 [(3-aminopropyl)(cyclohexylmethyl)phosphinic acid] and CGP 52432 (3-[[(3,4-dichlorophenyl)methyl]amino]propyl]diethoxymethyl)phosphinic acid), on spontaneous locomotor activity in mice. All drugs were acutely administered at the doses of 10 and 30 mg/kg (i.p.). The dose of 30 mg/kg of all drugs resulted in a significant stimulation of locomotor activity. The locomotor stimulation elicited by SCH 50911 was completely blocked by haloperidol (0.1 mg/kg, i.p.), suggesting that hyperactivity induced by blockade of the GABA B receptor is mediated by enhanced dopamine release. These results suggest the existence of a GABA B receptor-mediated tonic inhibition of dopamine neurons." @default.
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- W1975186840 date "2001-12-01" @default.
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- W1975186840 title "GABAB receptor inhibition causes locomotor stimulation in mice" @default.
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- W1975186840 doi "https://doi.org/10.1016/s0014-2999(01)01494-7" @default.
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