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- W1975189131 abstract "Intracellular transport is accomplished by molecular motors which pull cargos along cytoskeletal filaments. Many intracellular cargos are transported by two teams of molecular motors, for example by a team of kinesins and a team of dyneins. Such a cargo is observed to move bidirectionally along a microtubule, switching direction every few seconds. We have developed a theoretical model for cargo transport by two motor teams, which describes the interaction of the motor teams as a stochastic tug-of-war, and which incorporates the results of single-molecule experiments [1]. This model can explain experimental in vivo data previously thought incompatible with a tug-of-war, in particular fast bidirectional motion and the response to perturbations. In addition, the model shows that the finite processivity, the low detachment force, and the low backward velocity of biological motors are favorable for bidirectional cargo transport, leading to fast motion, enhanced diffusion, and enhanced processivity of the cargo. A similar model for cargo transport by a team of actin- and a team of microtubule based motors also results in enhanced processivity of the cargo on each filament type, in agreement with recent experimental results [2]. [1] M.J.I. Muller, S. Klumpp, R. Lipowsky, Proc. Natl. Acad. Sci. USA 105: 4609 (2008) [2] F. Berger, M.J.I. Muller, R. Lipowsky, EPL 87: 28002 (2009)" @default.
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- W1975189131 date "2010-01-01" @default.
- W1975189131 modified "2023-09-28" @default.
- W1975189131 title "Cargo Transport by Two Teams of Molecular Motors" @default.
- W1975189131 doi "https://doi.org/10.1016/j.bpj.2009.12.2341" @default.
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