Matches in SemOpenAlex for { <https://semopenalex.org/work/W1975199641> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W1975199641 endingPage "693" @default.
- W1975199641 startingPage "683" @default.
- W1975199641 abstract "The effect of norepinephrine (NE) upon human chorionic gonadotrophin (hCG) production by 6-8 week gestation placental explants has been investigated. NE (5 micrograms/ml) enhanced hCG secretion significantly from the second day of treatment. The stimulatory effect of NE on hCG secretion could be abolished by the alpha 1-receptor specific antagonist prazosin (10(-4) M) and partly diminished by the beta 1-receptor specific antagonist atenolol (10(-4) M), but was not influenced by the alpha 2-receptor specific antagonist yohimbine (10(-4) M). The involvement of the alpha-receptor in the regulation of hCG secretion was further confirmed by addition of the alpha-receptor agonist clonidine (10(-6) M) which had a similar stimulatory effect on hCG release but the effect was antagonized by both prazosin and yohimbine. Further study showed that NE induced a significant increase in cyclic adenosine monophosphate (cAMP) production by trophoblast tissue. Cyclic AMP secretion in the NE-treated group was fivefold higher than that of the control group. Both the protein kinase C (PKC) specific activator 1-deoyl-2-acetyl-sn-glycerol (OAG) and the PKC non-specific activator phorbol-12-myristate-13-acetate (PMA) had a stimulatory effect on hCG secretion, while the PKC inhibitor, 1-(5-isoquinolinylsulfonyl)-2-methyl-piperazine (H7) diminished the hCG secretion stimulated by NE. The effect of NE was blocked by the voltage-dependent calcium channel blocker nifedipine but not by the voltage-independent calcium channel blocker gadolinium chloride (GdCl3). On the other hand, anti-gonadotrophin releasing hormone (GnRH) IgG and the GnRH antagonist (D-Phe2, D-Trp6)-GnRH did not influence the stimulatory effect of NE on hCG release. The results indicate that NE regulates hCG production in human first trimester trophoblast tissue. The effect of NE was mainly mediated by alpha 1 and partly by beta 1 receptors. Cyclic AMP, the PKC signal transduction pathway and the voltage-dependent calcium channels were involved in NE action." @default.
- W1975199641 created "2016-06-24" @default.
- W1975199641 creator A5044495947 @default.
- W1975199641 creator A5085411353 @default.
- W1975199641 date "1993-11-01" @default.
- W1975199641 modified "2023-09-25" @default.
- W1975199641 title "Norepinephrine regulates human chorionic gonadotrophin production by first trimester trophoblast tissue in vitro" @default.
- W1975199641 cites W1982017809 @default.
- W1975199641 cites W1993766425 @default.
- W1975199641 cites W1995243750 @default.
- W1975199641 cites W1998605006 @default.
- W1975199641 cites W2014179587 @default.
- W1975199641 cites W2020946333 @default.
- W1975199641 cites W2024413640 @default.
- W1975199641 cites W2026083135 @default.
- W1975199641 cites W2032400259 @default.
- W1975199641 cites W2039898217 @default.
- W1975199641 cites W2061234318 @default.
- W1975199641 cites W2105544539 @default.
- W1975199641 cites W2123782956 @default.
- W1975199641 cites W2171127774 @default.
- W1975199641 cites W2412345898 @default.
- W1975199641 cites W2419437261 @default.
- W1975199641 cites W4293247451 @default.
- W1975199641 doi "https://doi.org/10.1016/s0143-4004(05)80385-6" @default.
- W1975199641 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8153089" @default.
- W1975199641 hasPublicationYear "1993" @default.
- W1975199641 type Work @default.
- W1975199641 sameAs 1975199641 @default.
- W1975199641 citedByCount "19" @default.
- W1975199641 countsByYear W19751996412016 @default.
- W1975199641 countsByYear W19751996412017 @default.
- W1975199641 countsByYear W19751996412018 @default.
- W1975199641 countsByYear W19751996412020 @default.
- W1975199641 countsByYear W19751996412022 @default.
- W1975199641 crossrefType "journal-article" @default.
- W1975199641 hasAuthorship W1975199641A5044495947 @default.
- W1975199641 hasAuthorship W1975199641A5085411353 @default.
- W1975199641 hasConcept C126322002 @default.
- W1975199641 hasConcept C134018914 @default.
- W1975199641 hasConcept C170493617 @default.
- W1975199641 hasConcept C185592680 @default.
- W1975199641 hasConcept C195794163 @default.
- W1975199641 hasConcept C2776108454 @default.
- W1975199641 hasConcept C2776885963 @default.
- W1975199641 hasConcept C2777676773 @default.
- W1975199641 hasConcept C2778938600 @default.
- W1975199641 hasConcept C2780648677 @default.
- W1975199641 hasConcept C55493867 @default.
- W1975199641 hasConcept C62478195 @default.
- W1975199641 hasConcept C71924100 @default.
- W1975199641 hasConcept C86803240 @default.
- W1975199641 hasConcept C88045685 @default.
- W1975199641 hasConceptScore W1975199641C126322002 @default.
- W1975199641 hasConceptScore W1975199641C134018914 @default.
- W1975199641 hasConceptScore W1975199641C170493617 @default.
- W1975199641 hasConceptScore W1975199641C185592680 @default.
- W1975199641 hasConceptScore W1975199641C195794163 @default.
- W1975199641 hasConceptScore W1975199641C2776108454 @default.
- W1975199641 hasConceptScore W1975199641C2776885963 @default.
- W1975199641 hasConceptScore W1975199641C2777676773 @default.
- W1975199641 hasConceptScore W1975199641C2778938600 @default.
- W1975199641 hasConceptScore W1975199641C2780648677 @default.
- W1975199641 hasConceptScore W1975199641C55493867 @default.
- W1975199641 hasConceptScore W1975199641C62478195 @default.
- W1975199641 hasConceptScore W1975199641C71924100 @default.
- W1975199641 hasConceptScore W1975199641C86803240 @default.
- W1975199641 hasConceptScore W1975199641C88045685 @default.
- W1975199641 hasIssue "6" @default.
- W1975199641 hasLocation W19751996411 @default.
- W1975199641 hasLocation W19751996412 @default.
- W1975199641 hasOpenAccess W1975199641 @default.
- W1975199641 hasPrimaryLocation W19751996411 @default.
- W1975199641 hasRelatedWork W1983935951 @default.
- W1975199641 hasRelatedWork W2027913950 @default.
- W1975199641 hasRelatedWork W2055714395 @default.
- W1975199641 hasRelatedWork W2063619316 @default.
- W1975199641 hasRelatedWork W2082001899 @default.
- W1975199641 hasRelatedWork W2123606909 @default.
- W1975199641 hasRelatedWork W2127219007 @default.
- W1975199641 hasRelatedWork W2133351730 @default.
- W1975199641 hasRelatedWork W2389547041 @default.
- W1975199641 hasRelatedWork W3191961327 @default.
- W1975199641 hasVolume "14" @default.
- W1975199641 isParatext "false" @default.
- W1975199641 isRetracted "false" @default.
- W1975199641 magId "1975199641" @default.
- W1975199641 workType "article" @default.