FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1975207312> ?p ?o ?g. }

• W1975207312 endingPage "913" @default.
• W1975207312 startingPage "901" @default.
• W1975207312 abstract "Cyclin D1 overexpression is a frequent change in hepatocellular carcinomas (HCCs). Our present study demonstrated that cyclin D1 overexpression with abundant cyclin E, cdk4, cdk2, and p27Kip1 (p27) occurred in neoplastic hepatocytes from the early stage of mouse hepatocarcinogenesis. While cyclin D1 expression was mainly found in the cytoplasm of the tumor cells, it shifted to the nucleus in association with cell proliferation after the animals were subjected to a partial hepatectomy (PH), and then returned once more to the cytoplasm when the cells became quiescent. Inhibition of PI3 kinase (PI3K) by Ly294002 in mouse HCC cells in vitro suppressed the nuclear shift of cyclin D1 as well as cell proliferation, while PI3K activation by PTEN suppression failed to induce nuclear shift of cyclin D1, suggesting that PI3K activation is essential but not sufficient for the cyclin D1 nuclear shift. While MEK-ERK1/2 inhibition by PD98059 and mTOR inhibition by rapamycin affected the cyclin D1 nuclear shift and cell proliferation to a lesser extent, both these inhibitors reduced cyclin D1 levels. Finally, although p27, cdk4 and calmodulin (CaM) were detected in the cyclin D1 immunoprecipitates from both quiescent and proliferating HCC cells, Hsc70 and SSeCKS were detected only in the immunoprecipitate from quiescent cells, and p21Waf1/Cip1 (p21) was detected only in that from proliferating cells, suggesting that the cyclin D1 complex is different in quiescent and proliferating cells. These observations indicate that the nuclear/cytoplasmic localization of cyclin D1 plays an important role in the proliferation/quiescence of neoplastic hepatocytes." @default.
• W1975207312 created "2016-06-24" @default.
• W1975207312 creator A5000143526 @default.
• W1975207312 creator A5019074580 @default.
• W1975207312 creator A5038329036 @default.
• W1975207312 creator A5061160958 @default.
• W1975207312 creator A5071022003 @default.
• W1975207312 date "2006-01-01" @default.
• W1975207312 modified "2023-09-30" @default.
• W1975207312 title "Neoplastic hepatocyte growth associated with cyclin D1 redistribution from the cytoplasm to the nucleus in mouse hepatocarcinogenesis" @default.
• W1975207312 cites W1496758942 @default.
• W1975207312 cites W1635667563 @default.
• W1975207312 cites W1665024321 @default.
• W1975207312 cites W1966571134 @default.
• W1975207312 cites W1970424369 @default.
• W1975207312 cites W1971079672 @default.
• W1975207312 cites W1974208182 @default.
• W1975207312 cites W1981427321 @default.
• W1975207312 cites W1982622947 @default.
• W1975207312 cites W1990925999 @default.
• W1975207312 cites W2001800178 @default.
• W1975207312 cites W2005173284 @default.
• W1975207312 cites W2012293213 @default.
• W1975207312 cites W2020992585 @default.
• W1975207312 cites W2027376766 @default.
• W1975207312 cites W2031523159 @default.
• W1975207312 cites W2035306088 @default.
• W1975207312 cites W2061023832 @default.
• W1975207312 cites W2088938008 @default.
• W1975207312 cites W2090576076 @default.
• W1975207312 cites W2095115211 @default.
• W1975207312 cites W2095368927 @default.
• W1975207312 cites W2104682649 @default.
• W1975207312 cites W2114918609 @default.
• W1975207312 cites W2115692032 @default.
• W1975207312 cites W2119874496 @default.
• W1975207312 cites W2121619780 @default.
• W1975207312 cites W2124018215 @default.
• W1975207312 cites W2127150495 @default.
• W1975207312 cites W2127219942 @default.
• W1975207312 cites W2127649862 @default.
• W1975207312 cites W2133697463 @default.
• W1975207312 cites W2136809856 @default.
• W1975207312 cites W2150456795 @default.
• W1975207312 cites W2154111513 @default.
• W1975207312 cites W2161320702 @default.
• W1975207312 cites W2171058117 @default.
• W1975207312 cites W2171852242 @default.
• W1975207312 cites W2253927451 @default.
• W1975207312 cites W31572314 @default.
• W1975207312 cites W4211173486 @default.
• W1975207312 cites W4237329722 @default.
• W1975207312 cites W81266651 @default.
• W1975207312 doi "https://doi.org/10.1002/mc.20204" @default.
• W1975207312 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17013836" @default.
• W1975207312 hasPublicationYear "2006" @default.
• W1975207312 type Work @default.
• W1975207312 sameAs 1975207312 @default.
• W1975207312 citedByCount "41" @default.
• W1975207312 countsByYear W19752073122012 @default.
• W1975207312 countsByYear W19752073122013 @default.
• W1975207312 countsByYear W19752073122014 @default.
• W1975207312 countsByYear W19752073122016 @default.
• W1975207312 countsByYear W19752073122017 @default.
• W1975207312 countsByYear W19752073122020 @default.
• W1975207312 countsByYear W19752073122021 @default.
• W1975207312 countsByYear W19752073122022 @default.
• W1975207312 countsByYear W19752073122023 @default.
• W1975207312 crossrefType "journal-article" @default.
• W1975207312 hasAuthorship W1975207312A5000143526 @default.
• W1975207312 hasAuthorship W1975207312A5019074580 @default.
• W1975207312 hasAuthorship W1975207312A5038329036 @default.
• W1975207312 hasAuthorship W1975207312A5061160958 @default.
• W1975207312 hasAuthorship W1975207312A5071022003 @default.
• W1975207312 hasBestOaLocation W19752073122 @default.
• W1975207312 hasConcept C11882975 @default.
• W1975207312 hasConcept C120089663 @default.
• W1975207312 hasConcept C124320809 @default.
• W1975207312 hasConcept C1491633281 @default.
• W1975207312 hasConcept C153911025 @default.
• W1975207312 hasConcept C16438837 @default.
• W1975207312 hasConcept C199835354 @default.
• W1975207312 hasConcept C28179978 @default.
• W1975207312 hasConcept C29537977 @default.
• W1975207312 hasConcept C502942594 @default.
• W1975207312 hasConcept C55493867 @default.
• W1975207312 hasConcept C62112901 @default.
• W1975207312 hasConcept C86803240 @default.
• W1975207312 hasConcept C94561458 @default.
• W1975207312 hasConcept C95444343 @default.
• W1975207312 hasConcept C9743823 @default.
• W1975207312 hasConceptScore W1975207312C11882975 @default.
• W1975207312 hasConceptScore W1975207312C120089663 @default.
• W1975207312 hasConceptScore W1975207312C124320809 @default.
• W1975207312 hasConceptScore W1975207312C1491633281 @default.
• W1975207312 hasConceptScore W1975207312C153911025 @default.
• W1975207312 hasConceptScore W1975207312C16438837 @default.
• W1975207312 hasConceptScore W1975207312C199835354 @default.

• next