Matches in SemOpenAlex for { <https://semopenalex.org/work/W1975218706> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W1975218706 endingPage "830" @default.
- W1975218706 startingPage "826" @default.
- W1975218706 abstract "Grancalcin, one of the penta-EF-hand Ca(2+) binding proteins, is expressed at high levels in polymorphonuclear granulocytes (neutrophils). EF-hand proteins are implicated in the regulation of diverse processes including cell migration, apoptosis, and mobilization of neutrophil effector functions. To determine the role of grancalcin in vivo, we inactivated the gene encoding grancalcin (Gca) in embryonic stem cells and generated grancalcin-deficient mice. Homozygous Gca mutants appeared healthy and reproduced normally. Leukocyte recruitment into the peritoneal cavity upon induction of inflammation was not significantly affected by the absence of grancalcin. The mutants also resisted systemic fungal infection similarly to wild-type mice, and in vitro killing of Staphylococcus aureus by inflammatory cells was not significantly impaired. While marginally increased survival rates of mutants faced with endotoxic shock may indicate a contribution of grancalcin to immunopathogenesis, it is not essential for vital leukocyte effector functions required to control microbial infections." @default.
- W1975218706 created "2016-06-24" @default.
- W1975218706 creator A5025311351 @default.
- W1975218706 creator A5038694084 @default.
- W1975218706 creator A5072624656 @default.
- W1975218706 creator A5075765295 @default.
- W1975218706 creator A5080658074 @default.
- W1975218706 date "2003-02-01" @default.
- W1975218706 modified "2023-10-17" @default.
- W1975218706 title "Granulocyte Function in Grancalcin-Deficient Mice" @default.
- W1975218706 cites W1557482814 @default.
- W1975218706 cites W1629629920 @default.
- W1975218706 cites W1969626366 @default.
- W1975218706 cites W1970543829 @default.
- W1975218706 cites W1970935798 @default.
- W1975218706 cites W1973287769 @default.
- W1975218706 cites W1981845572 @default.
- W1975218706 cites W1996067419 @default.
- W1975218706 cites W2005869248 @default.
- W1975218706 cites W2017863044 @default.
- W1975218706 cites W2039490296 @default.
- W1975218706 cites W2045723131 @default.
- W1975218706 cites W2084814184 @default.
- W1975218706 cites W2092289140 @default.
- W1975218706 cites W2092565908 @default.
- W1975218706 cites W2108235369 @default.
- W1975218706 cites W2111657224 @default.
- W1975218706 cites W2140061120 @default.
- W1975218706 cites W2167307101 @default.
- W1975218706 cites W2240067531 @default.
- W1975218706 doi "https://doi.org/10.1128/mcb.23.3.826-830.2003" @default.
- W1975218706 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/140701" @default.
- W1975218706 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12529388" @default.
- W1975218706 hasPublicationYear "2003" @default.
- W1975218706 type Work @default.
- W1975218706 sameAs 1975218706 @default.
- W1975218706 citedByCount "20" @default.
- W1975218706 countsByYear W19752187062012 @default.
- W1975218706 countsByYear W19752187062015 @default.
- W1975218706 countsByYear W19752187062016 @default.
- W1975218706 countsByYear W19752187062019 @default.
- W1975218706 countsByYear W19752187062021 @default.
- W1975218706 countsByYear W19752187062022 @default.
- W1975218706 countsByYear W19752187062023 @default.
- W1975218706 crossrefType "journal-article" @default.
- W1975218706 hasAuthorship W1975218706A5025311351 @default.
- W1975218706 hasAuthorship W1975218706A5038694084 @default.
- W1975218706 hasAuthorship W1975218706A5072624656 @default.
- W1975218706 hasAuthorship W1975218706A5075765295 @default.
- W1975218706 hasAuthorship W1975218706A5080658074 @default.
- W1975218706 hasBestOaLocation W19752187061 @default.
- W1975218706 hasConcept C104317684 @default.
- W1975218706 hasConcept C143065580 @default.
- W1975218706 hasConcept C153911025 @default.
- W1975218706 hasConcept C203014093 @default.
- W1975218706 hasConcept C2776914184 @default.
- W1975218706 hasConcept C2777983669 @default.
- W1975218706 hasConcept C51785407 @default.
- W1975218706 hasConcept C54355233 @default.
- W1975218706 hasConcept C86803240 @default.
- W1975218706 hasConcept C89423630 @default.
- W1975218706 hasConcept C95444343 @default.
- W1975218706 hasConceptScore W1975218706C104317684 @default.
- W1975218706 hasConceptScore W1975218706C143065580 @default.
- W1975218706 hasConceptScore W1975218706C153911025 @default.
- W1975218706 hasConceptScore W1975218706C203014093 @default.
- W1975218706 hasConceptScore W1975218706C2776914184 @default.
- W1975218706 hasConceptScore W1975218706C2777983669 @default.
- W1975218706 hasConceptScore W1975218706C51785407 @default.
- W1975218706 hasConceptScore W1975218706C54355233 @default.
- W1975218706 hasConceptScore W1975218706C86803240 @default.
- W1975218706 hasConceptScore W1975218706C89423630 @default.
- W1975218706 hasConceptScore W1975218706C95444343 @default.
- W1975218706 hasIssue "3" @default.
- W1975218706 hasLocation W19752187061 @default.
- W1975218706 hasLocation W19752187062 @default.
- W1975218706 hasLocation W19752187063 @default.
- W1975218706 hasLocation W19752187064 @default.
- W1975218706 hasOpenAccess W1975218706 @default.
- W1975218706 hasPrimaryLocation W19752187061 @default.
- W1975218706 hasRelatedWork W1969421403 @default.
- W1975218706 hasRelatedWork W2013185554 @default.
- W1975218706 hasRelatedWork W2064207257 @default.
- W1975218706 hasRelatedWork W2150065613 @default.
- W1975218706 hasRelatedWork W2156423843 @default.
- W1975218706 hasRelatedWork W2156674132 @default.
- W1975218706 hasRelatedWork W2171277769 @default.
- W1975218706 hasRelatedWork W4231043616 @default.
- W1975218706 hasRelatedWork W4247436401 @default.
- W1975218706 hasRelatedWork W4386444087 @default.
- W1975218706 hasVolume "23" @default.
- W1975218706 isParatext "false" @default.
- W1975218706 isRetracted "false" @default.
- W1975218706 magId "1975218706" @default.
- W1975218706 workType "article" @default.