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• W1975218920 abstract "Live attenuated Salmonella strains have been extensively explored as oral delivery systems for recombinant vaccine antigens and effector proteins with immunoadjuvant and immunomodulatory potential. The feasibility of this approach was demonstrated in human vaccination trials for various antigens. However, immunization efficiencies with live vaccines are generally significantly lower compared to those monitored in parenteral immunizations with the same vaccine antigen. This is, at least partly, due to the lack of secretory expression systems, enabling large-scale extracellular delivery of vaccine and effector proteins by these strains. Because of their low complexity and the terminal location of the secretion signal in the secreted protein, Type I (ATP-binding cassette) secretion systems appear to be particularly suited for development of such recombinant extracellular expression systems. So far, the Escherichia coli hemolysin system is the only Type I secretion system, which has been adapted to recombinant protein secretion in Salmonella. However, this system has a number of disadvantages, including low secretion capacity, complex genetic regulation, and structural restriction to the secreted protein, which eventually hinder high-level in vivo delivery of recombinant vaccines and effector proteins. Thus, the development of more efficient recombinant protein secretion systems, based on Type I exporters can help to improve efficacies of live recombinant Salmonella vaccines. Type I secretion systems, mediating secretion of bacterial surface layer proteins, such as RsaA in Caulobacter crescentus, are discussed as promising candidates for improved secretory delivery systems." @default.
• W1975218920 created "2016-06-24" @default.
• W1975218920 creator A5001172079 @default.
• W1975218920 creator A5091863121 @default.
• W1975218920 date "2003-07-01" @default.
• W1975218920 modified "2023-10-09" @default.
• W1975218920 title "Secretory delivery of recombinant proteins in attenuated<i>Salmonella</i>strains: potential and limitations of Type I protein transporters" @default.
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• W1975218920 doi "https://doi.org/10.1016/s0928-8244(03)00092-0" @default.
• W1975218920 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12832111" @default.
• W1975218920 hasPublicationYear "2003" @default.
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