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• W1975231567 abstract "Numerous transcription factors self-assemble into different order oligomeric species [1] in a way that is actively regulated by the cell. Here, we use a novel quantitative framework to capture the effects of modulated self-assembly in gene expression [2]. We show that this mechanism provides precision and flexibility, two seemingly antagonistic properties, to the sensing of diverse cellular signals by systems that share common elements present in transcription factors like p53, NF-κB, STATs, Oct and RXR [2]. Applied to the nuclear hormone receptor RXR, this framework accurately reproduces a broad range of classical sets of gene expression data and corroborates the existence of a precise functional regime with flexible properties that can be controlled both at a genome-wide scale and at the individual promoter level. We show that key to the success of the computational framework is that it incorporates the regulatory complexity of RXR mediated signaling [1,3,4], which involve multiple DNA-binding sites at the promoters of retinoid targeted genes and the ability of RXR to precisely tailor the response to each individual gene depending on the arrangement of these sites.References:[1] L. Saiz and J.M.G. Vilar, Nature/EMBO Molecular Systems Biology, 2, doi:10.1038/msb4100061 (2006).[2] J.M.G. Vilar and L. Saiz, Nucleic Acids Research, 39: 6854-6863 (2011). Highlighted as a featured article.[3] J.M.G. Vilar and L. Saiz, Bioinformatics, 26:2060-2061 (2010).[4] L. Saiz and M.L. Klein, Acc. Chem. Res., 35: 482-489 (2002)." @default.
• W1975231567 created "2016-06-24" @default.
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• W1975231567 date "2012-01-01" @default.
• W1975231567 modified "2023-09-28" @default.
• W1975231567 title "Control of Gene Expression by Modulated Self-Assembly" @default.
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• W1975231567 doi "https://doi.org/10.1016/j.bpj.2011.11.1588" @default.
• W1975231567 hasPublicationYear "2012" @default.
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