FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1975233292> ?p ?o ?g. }

• W1975233292 endingPage "2835" @default.
• W1975233292 startingPage "2825" @default.
• W1975233292 abstract "The identification of individuals who should undergo hereditary nonpolyposis colorectal cancer (HNPCC) genetic testing remains a critical issue. The Bethesda guidelines were developed to preselect patients for microsatellite instability (MSI) testing before germline mutation screening. These criteria have been revised, and a new set of recommendations, the revised Bethesda guidelines, has been proposed.To evaluate the performance of these revised guidelines for identifying patients with HNPCC in a series of unselected consecutive patients and compare this revised guidelines-based approach with a molecular strategy (MSI testing for all tumors, followed by exclusion of MSI-positive sporadic cases from mutational testing).The study included 214 patients with newly diagnosed colorectal cancer. The MSI analysis was performed for all tumors. Germline testing, guided by immunohistochemical staining for mismatch repair proteins, was performed for patients with MSI-positive tumors. Sporadic MSI-positive tumors were identified by screening for BRAF mutation and MLH1 promoter methylation.Ninety patients (42.1%) met the revised guidelines. Twenty-one patients (9.8%) had MSI-positive tumors. Germline testing identified eight mutations (3.7%) (MSH2 N = 5, MLH1 N = 2, MSH6 N =1). The revised guidelines failed to identify 2 of the 8 probands (aged 67 and 81 yr, both with no family history). In contrast, the molecular strategy identified all patients requiring testing for germline mutation. The percentages of patients selected for germline testing by the revised guidelines and the molecular strategy were 4.2% and 5.1%, respectively.The revised Bethesda guidelines did not identify all HNPCC cases in our series. The molecular approach identified all HNPCC patients with MSI-positive tumors, increasing the workload for germline testing only slightly." @default.
• W1975233292 created "2016-06-24" @default.
• W1975233292 creator A5001546426 @default.
• W1975233292 creator A5005860862 @default.
• W1975233292 creator A5012784092 @default.
• W1975233292 creator A5014936965 @default.
• W1975233292 creator A5021709517 @default.
• W1975233292 creator A5024251845 @default.
• W1975233292 creator A5024946017 @default.
• W1975233292 creator A5029021552 @default.
• W1975233292 creator A5036295652 @default.
• W1975233292 creator A5051580508 @default.
• W1975233292 creator A5055519983 @default.
• W1975233292 creator A5055598987 @default.
• W1975233292 creator A5058306194 @default.
• W1975233292 creator A5072922609 @default.
• W1975233292 creator A5077144398 @default.
• W1975233292 creator A5085470109 @default.
• W1975233292 creator A5088103291 @default.
• W1975233292 creator A5089759719 @default.
• W1975233292 creator A5089818289 @default.
• W1975233292 creator A5090177578 @default.
• W1975233292 date "2008-11-01" @default.
• W1975233292 modified "2023-10-18" @default.
• W1975233292 title "Identification in Daily Practice of Patients With Lynch Syndrome (Hereditary Nonpolyposis Colorectal Cancer): Revised Bethesda Guidelines-Based Approach<i>Versus</i>Molecular Screening" @default.
• W1975233292 cites W1907599506 @default.
• W1975233292 cites W1972878243 @default.
• W1975233292 cites W1974592005 @default.
• W1975233292 cites W1991106907 @default.
• W1975233292 cites W2007496261 @default.
• W1975233292 cites W2010053675 @default.
• W1975233292 cites W2029904263 @default.
• W1975233292 cites W2035652552 @default.
• W1975233292 cites W2037458235 @default.
• W1975233292 cites W2044643325 @default.
• W1975233292 cites W2063110349 @default.
• W1975233292 cites W2066833606 @default.
• W1975233292 cites W2079819604 @default.
• W1975233292 cites W2081680846 @default.
• W1975233292 cites W2096371251 @default.
• W1975233292 cites W2100899721 @default.
• W1975233292 cites W2103982179 @default.
• W1975233292 cites W2112565258 @default.
• W1975233292 cites W2112677111 @default.
• W1975233292 cites W2118087448 @default.
• W1975233292 cites W2119030852 @default.
• W1975233292 cites W2124896165 @default.
• W1975233292 cites W2125436503 @default.
• W1975233292 cites W2128793721 @default.
• W1975233292 cites W2135982041 @default.
• W1975233292 cites W2136615212 @default.
• W1975233292 cites W2136843245 @default.
• W1975233292 cites W2140937522 @default.
• W1975233292 cites W2142826725 @default.
• W1975233292 cites W2155157454 @default.
• W1975233292 cites W2156299764 @default.
• W1975233292 cites W2159429807 @default.
• W1975233292 cites W2161989604 @default.
• W1975233292 cites W2162362353 @default.
• W1975233292 cites W2163295338 @default.
• W1975233292 cites W2168290255 @default.
• W1975233292 cites W2170554644 @default.
• W1975233292 cites W4231337390 @default.
• W1975233292 cites W4239437841 @default.
• W1975233292 doi "https://doi.org/10.1111/j.1572-0241.2008.02084.x" @default.
• W1975233292 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18759827" @default.
• W1975233292 hasPublicationYear "2008" @default.
• W1975233292 type Work @default.
• W1975233292 sameAs 1975233292 @default.
• W1975233292 citedByCount "112" @default.
• W1975233292 countsByYear W19752332922012 @default.
• W1975233292 countsByYear W19752332922013 @default.
• W1975233292 countsByYear W19752332922014 @default.
• W1975233292 countsByYear W19752332922015 @default.
• W1975233292 countsByYear W19752332922016 @default.
• W1975233292 countsByYear W19752332922017 @default.
• W1975233292 countsByYear W19752332922018 @default.
• W1975233292 countsByYear W19752332922019 @default.
• W1975233292 countsByYear W19752332922020 @default.
• W1975233292 countsByYear W19752332922021 @default.
• W1975233292 countsByYear W19752332922022 @default.
• W1975233292 countsByYear W19752332922023 @default.
• W1975233292 crossrefType "journal-article" @default.
• W1975233292 hasAuthorship W1975233292A5001546426 @default.
• W1975233292 hasAuthorship W1975233292A5005860862 @default.
• W1975233292 hasAuthorship W1975233292A5012784092 @default.
• W1975233292 hasAuthorship W1975233292A5014936965 @default.
• W1975233292 hasAuthorship W1975233292A5021709517 @default.
• W1975233292 hasAuthorship W1975233292A5024251845 @default.
• W1975233292 hasAuthorship W1975233292A5024946017 @default.
• W1975233292 hasAuthorship W1975233292A5029021552 @default.
• W1975233292 hasAuthorship W1975233292A5036295652 @default.
• W1975233292 hasAuthorship W1975233292A5051580508 @default.
• W1975233292 hasAuthorship W1975233292A5055519983 @default.
• W1975233292 hasAuthorship W1975233292A5055598987 @default.
• W1975233292 hasAuthorship W1975233292A5058306194 @default.
• W1975233292 hasAuthorship W1975233292A5072922609 @default.
• W1975233292 hasAuthorship W1975233292A5077144398 @default.

• next