FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1975242893> ?p ?o ?g. }

• W1975242893 endingPage "530" @default.
• W1975242893 startingPage "521" @default.
• W1975242893 abstract "1 The in vitro metabolism of omeprazole was studied in human liver microsomes in order to define the metabolic pathways and identify the cytochrome P450 (CYP) isoforms responsible for the formation of the major omeprazole metabolites. 2 The four major metabolites identified in vitro, in tentative order of importance, were hydroxyomeprazole, omeprazole sulphone, 5-O-desmethylomeprazole, and an unidentified compound termed metabolite X. Omeprazole pyridone was also detected but could not be quantitated. Incubation of hydroxyomeprazole and omeprazole sulphone with human microsomes resulted in both cases in formation of the hydroxysulphone. The kinetics of formation of the four primary metabolites studied were biphasic suggesting the involvement of multiple CYP isoforms in each case. Further studies used substrate concentrations at which the high affinity activities predominated. 3 Formation of the major metabolite, hydroxyomeprazole, was significantly correlated with S-mephenytoin hydroxylase and with benzo[a]pyrene metabolism and CYP3A content. Inhibition studies with isoform selective inhibitors also indicated a dominant role of S-mephenytoin hydroxylase with some CYP3A contribution in the formation of hydroxyomeprazole. Correlation and inhibition data for the sulphone and metabolite X were consistent with a predominant role of the CYP3A subfamily in formation of these metabolites. Formation of 5-O-desmethylomeprazole was inhibited by both R, S-mephenytoin and quinidine, indicating that both S-mephenytoin hydroxylase and CYP2D6 may mediate this reaction in human liver microsomes and in vivo. 4 The Vmax/Km (indicator of intrinsic clearance in vivo) for hydroxyomeprazole was four times greater than that for omeprazole sulphone. Consistent with findings in vivo, the results predict that omeprazole clearance in vivo would be reduced in poor metabolisers of mephenytoin due to reduction in the dominant partial metabolic clearance to hydroxyomeprazole." @default.
• W1975242893 created "2016-06-24" @default.
• W1975242893 creator A5008901409 @default.
• W1975242893 creator A5021671772 @default.
• W1975242893 creator A5042378744 @default.
• W1975242893 creator A5053870539 @default.
• W1975242893 creator A5079737422 @default.
• W1975242893 creator A5079921975 @default.
• W1975242893 creator A5082564504 @default.
• W1975242893 date "1993-12-01" @default.
• W1975242893 modified "2023-10-17" @default.
• W1975242893 title "Identification of human liver cytochrome P450 isoforms mediating omeprazole metabolism" @default.
• W1975242893 cites W1775749144 @default.
• W1975242893 cites W1820017190 @default.
• W1975242893 cites W1821066907 @default.
• W1975242893 cites W1841965453 @default.
• W1975242893 cites W1888004082 @default.
• W1975242893 cites W1968563067 @default.
• W1975242893 cites W1973615600 @default.
• W1975242893 cites W1984526747 @default.
• W1975242893 cites W1985499927 @default.
• W1975242893 cites W1991163272 @default.
• W1975242893 cites W1998573208 @default.
• W1975242893 cites W2001064866 @default.
• W1975242893 cites W2004224601 @default.
• W1975242893 cites W2007972960 @default.
• W1975242893 cites W2014884679 @default.
• W1975242893 cites W2017472773 @default.
• W1975242893 cites W2027458234 @default.
• W1975242893 cites W2032038267 @default.
• W1975242893 cites W2035787557 @default.
• W1975242893 cites W2058578252 @default.
• W1975242893 cites W2063290207 @default.
• W1975242893 cites W2088411628 @default.
• W1975242893 cites W2121281083 @default.
• W1975242893 cites W2122321065 @default.
• W1975242893 cites W2146307640 @default.
• W1975242893 cites W2153486162 @default.
• W1975242893 cites W2163209725 @default.
• W1975242893 cites W2168234648 @default.
• W1975242893 cites W2330367835 @default.
• W1975242893 cites W2410779580 @default.
• W1975242893 cites W2418782386 @default.
• W1975242893 cites W4229790662 @default.
• W1975242893 doi "https://doi.org/10.1111/j.1365-2125.1993.tb00410.x" @default.
• W1975242893 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1364656" @default.
• W1975242893 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12959268" @default.
• W1975242893 hasPublicationYear "1993" @default.
• W1975242893 type Work @default.
• W1975242893 sameAs 1975242893 @default.
• W1975242893 citedByCount "211" @default.
• W1975242893 countsByYear W19752428932012 @default.
• W1975242893 countsByYear W19752428932013 @default.
• W1975242893 countsByYear W19752428932014 @default.
• W1975242893 countsByYear W19752428932015 @default.
• W1975242893 countsByYear W19752428932016 @default.
• W1975242893 countsByYear W19752428932017 @default.
• W1975242893 countsByYear W19752428932018 @default.
• W1975242893 countsByYear W19752428932019 @default.
• W1975242893 countsByYear W19752428932020 @default.
• W1975242893 countsByYear W19752428932021 @default.
• W1975242893 countsByYear W19752428932022 @default.
• W1975242893 countsByYear W19752428932023 @default.
• W1975242893 crossrefType "journal-article" @default.
• W1975242893 hasAuthorship W1975242893A5008901409 @default.
• W1975242893 hasAuthorship W1975242893A5021671772 @default.
• W1975242893 hasAuthorship W1975242893A5042378744 @default.
• W1975242893 hasAuthorship W1975242893A5053870539 @default.
• W1975242893 hasAuthorship W1975242893A5079737422 @default.
• W1975242893 hasAuthorship W1975242893A5079921975 @default.
• W1975242893 hasAuthorship W1975242893A5082564504 @default.
• W1975242893 hasBestOaLocation W19752428932 @default.
• W1975242893 hasConcept C109650736 @default.
• W1975242893 hasConcept C11824378 @default.
• W1975242893 hasConcept C119795356 @default.
• W1975242893 hasConcept C140840227 @default.
• W1975242893 hasConcept C150903083 @default.
• W1975242893 hasConcept C181199279 @default.
• W1975242893 hasConcept C185592680 @default.
• W1975242893 hasConcept C207001950 @default.
• W1975242893 hasConcept C2776838488 @default.
• W1975242893 hasConcept C2777477808 @default.
• W1975242893 hasConcept C2777498785 @default.
• W1975242893 hasConcept C526171541 @default.
• W1975242893 hasConcept C55493867 @default.
• W1975242893 hasConcept C62231903 @default.
• W1975242893 hasConcept C86803240 @default.
• W1975242893 hasConcept C87644729 @default.
• W1975242893 hasConcept C98274493 @default.
• W1975242893 hasConceptScore W1975242893C109650736 @default.
• W1975242893 hasConceptScore W1975242893C11824378 @default.
• W1975242893 hasConceptScore W1975242893C119795356 @default.
• W1975242893 hasConceptScore W1975242893C140840227 @default.
• W1975242893 hasConceptScore W1975242893C150903083 @default.
• W1975242893 hasConceptScore W1975242893C181199279 @default.
• W1975242893 hasConceptScore W1975242893C185592680 @default.
• W1975242893 hasConceptScore W1975242893C207001950 @default.
• W1975242893 hasConceptScore W1975242893C2776838488 @default.

• next