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• W1975264004 abstract "<em>BACKGROUND</em>: Production of antibodies that are specific for allergens is an important pathological process in inflammatory allergic diseases. These contain the antibodies against antigens of <em>Candida albicans</em>, one of the normal microbial flora in an intestinal tract. We studied the effects of the prednisolone administration on the production of anti-<em>Candida</em> antibodies in the gastrointestinally <em>C. albicans</em>-colonized mice.<em>Methods and Materials</em>: BALB/c mice, treated with antibacterial antibiotics to decontaminate indigenous intestinal bacterial flora, were inoculated intragastrically with <em>C. albicans</em>. The mice, in which <em>C. albicans</em> grows intestinally, were administered prednisolone to induce temporary immunosuppression. The <em>Candida</em> growth in their intestinal tract and their antibody response to <em>Candida</em> were examined.<em>Results</em>: Antibiotic treatment allowed establishment of <em>C. albicans</em> gastrointestinal colonization, but did not cause subsequent systemic dissemination of <em>C. albicans</em> in all the animals. When these animals received an additional treatment with prednisolone, they showed a significantly higher population of <em>C. albicans</em> in their feces than those of animals treated with antibiotics alone, and the organisms were recovered even from their kidney. This systemic dissemination by <em>C. albicans</em> appeared to be temporal, because all the mice survived without any symptoms for more than 2 months. Examination of the serum titers of total immunoglobulin (Ig)E antibodies and specific IgE and IgG antibodies against <em>Candida</em> antigens demonstrated that titers of total IgE increased, partially by day 14 and clearly at day 27, in prednisolone-treated <em>Candida</em>-colonized mice. Without prednisolone treatment, an increment of the serum titer was scarcely observed. By day 27, corresponding to the increase of total IgE, the anti-<em>Candida</em> IgE and IgG titer increased in mice of the prednisolone-treated group.<em>Conclusion</em>: Administration of prednisolone to <em>Candida</em>-colonized mice can induce production of the IgG, IgE antibodies against <em>Candida</em> antigens, perhaps through temporal systemic dissemination of <em>Candida</em> from the intestinal tract." @default.
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• W1975264004 date "2004-01-01" @default.
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• W1975264004 title "Production of anti-Candida antibodies in mice with gut colonization of Candida albicans" @default.
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• W1975264004 doi "https://doi.org/10.1080/09511920410001713510" @default.
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