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- W1975264966 endingPage "387" @default.
- W1975264966 startingPage "377" @default.
- W1975264966 abstract "The laboratory has a critical role to play in the screening and diagnosis of primary aldosteronism. This review highlights some of the important analytical considerations and the new developments in the determination of aldosterone and renin. The review considered the published literature and clinical practice guidelines in the area of primary aldosteronism. A brief introduction to primary aldosteronism is provided. A detailed description of the pre-analytical, analytical and post-analytical considerations for the laboratory determination of aldosterone, renin and the aldosterone to renin ratio follows. The lack of internationally accepted standardized methodologies and standard reference material has impeded screening and diagnosis of primary aldosteronism. The development of more accurate and sensitive methods by LC–MS/MS has improved the reliability of aldosterone and renin testing and the availability of commercial chemiluminescent assays may improve the standardization of reporting. Laboratorians need to understand the strengths and weaknesses of their analytical approach and ensure that their interpretative reports are appropriate to their assays." @default.
- W1975264966 created "2016-06-24" @default.
- W1975264966 creator A5022146332 @default.
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- W1975264966 creator A5061471977 @default.
- W1975264966 creator A5080943995 @default.
- W1975264966 date "2015-04-01" @default.
- W1975264966 modified "2023-09-27" @default.
- W1975264966 title "Laboratory challenges in primary aldosteronism screening and diagnosis" @default.
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