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• W1975271754 endingPage "1706" @default.
• W1975271754 startingPage "1697" @default.
• W1975271754 abstract "During priming, naive CD4(+) Th cells differentiate into cells that produce either IFN-gamma or IL-4. Even though the cascade of pathways that induces IL-4-producing Th2 cells has been determined in vitro, the signals promoting Th2 differentiation under physiological conditions remain enigmatic, especially the natural role of the single most important Th2-inducing signal,IL-4. Using Th2 and naive Th cells, each expressing a distinct transgenic TCR, here we show that Th2 cells migrate with the same dynamics as naive Th cells in draining lymph nodes and bind to the same DC, when driven by antigen in complete Freund's adjuvant (CFA). Th2-cell-derived IL-4 deviates CFA-induced Th1 development toward a Th2 phenotype, if both cell populations co-localize in the same T cell area, and are activated simultaneously. Thus, intranodal Th2 cells directly influence Th cell differentiation in vivo, but only under restricted conditions. These findings have implications for the design of cytokine-based therapies and explain the spreading of Th2 responses to multiple aeroallergens in allergic asthma, where naive Th and Th2 cells co-localize in lung-draining lymph nodes." @default.
• W1975271754 created "2016-06-24" @default.
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• W1975271754 date "2003-06-01" @default.
• W1975271754 modified "2023-10-14" @default.
• W1975271754 title "Th2 cells shape the differentiation of developing T cell responses during interactions with dendritic cells in vivo" @default.
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• W1975271754 doi "https://doi.org/10.1002/eji.200323809" @default.
• W1975271754 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12778488" @default.
• W1975271754 hasPublicationYear "2003" @default.
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