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• W1975294508 startingPage "5958" @default.
• W1975294508 abstract "The Sonogashira and Stille cross-coupling reactions have been employed in the synthesis of several non-nucleoside reverse transcriptase inhibitors (NNRTIs) in the alkenyldiarylmethane (ADAM) series. The synthesis has been carried out both in solution and on a solid support. In contrast to previous syntheses of NNRTIs in the ADAM series, the present strategy allows the incorporation of differently substituted aromatic rings in a stereochemically defined fashion. The most potent of the new ADAMs inhibited the cytopathic effect of HIV-1RF in CEM-SS cell culture with an EC50 value of 20 nM." @default.
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• W1975294508 date "2001-05-24" @default.
• W1975294508 modified "2023-09-27" @default.
• W1975294508 title "Solid-Phase Synthesis of the Alkenyldiarylmethane (ADAM) Series of Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitors" @default.
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• W1975294508 doi "https://doi.org/10.1021/jo0100291" @default.
• W1975294508 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11529718" @default.
• W1975294508 hasPublicationYear "2001" @default.
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