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- W1975296948 abstract "No AccessJournal of UrologyPEDIATRIC UROLOGY1 Jun 2003Measuring Glomerular Filtration Rate with Cystatin C and β-Trace Protein in Children with Spina Bifida ANNE PHAM-HUY, MICHAEL LEONARD, NATHALIE LEPAGE, JACQUELINE HALTON, and GUIDO FILLER ANNE PHAM-HUYANNE PHAM-HUY More articles by this author , MICHAEL LEONARDMICHAEL LEONARD Financial interest and/or other relationship with Pharmacia. More articles by this author , NATHALIE LEPAGENATHALIE LEPAGE More articles by this author , JACQUELINE HALTONJACQUELINE HALTON More articles by this author , and GUIDO FILLERGUIDO FILLER More articles by this author View All Author Informationhttps://doi.org/10.1097/01.ju.0000060205.23406.13AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: We compared the diagnostic performance of cystatin C and β-trace protein with serum creatinine and the Schwartz formula for the estimation of glomerular filtration rate in children with spina bifida. Materials and Methods: Cystatin C, β-trace protein and serum creatinine in children who underwent routine measurement of glomerular filtration rate were obtained in a prospective study. A spina bifida group (27 measurements in 27 patients 1.4 to 20.0 years old, 15 female, 12 male) was compared with a group of controls (211 measurements in 201 patients with various other renal pathologies 1.0 to 20.2 years old, 89 female, 122 male). All patients underwent nuclear medicine clearance investigations with 99mtechnetium diethylenetetraminepentaacetic acid. Z scores were calculated for body mass index, height and weight. Receiver operating characteristic (ROC) analysis and ROC plots were done to assess their diagnostic accuracy. Results: Serum creatinine and the Schwartz formula did not correlate with glomerular filtration rate in the patients with spina bifida. Correlation coefficients for cystatin C were 0.45 and 0.84 in the spina bifida and control groups, respectively, while correlation coefficients for β-trace protein were 0.31 and 0.75, respectively. For both groups ROC area was highest for cystatin C (up to 0.97 ROC area in control group). Conclusions: Only cystatin C served as a suitable marker to estimate glomerular filtration rate in patients with spina bifida. Cystatin C proved to be a superior marker in patients with spina bifida. In the control group the Schwartz formula was comparable to cystatin C and β-trace protein, although cystatin C remained superior. References 1 : Creatinine: an inadequate filtration marker in glomerular diseases. Am J Med1980; 69: 177. Google Scholar 2 : Limitations of creatinine as a filtration marker in glomerulopathic patients. Kidney Int1985; 28: 830. Google Scholar 3 : A simple estimate of glomerular filtration rate in children derived from body length and plasma creatinine. Pediatrics1976; 58: 259. Google Scholar 4 : Limitations to body length/serum creatinine ratio as an estimate of glomerular filtration in children. Pediatr Nephrol1996; 10: 709. Google Scholar 5 : Serum creatinine is a poor marker of glomerular filtration rate in patients with spina bifida. Dev Med Child Neurol1997; 39: 808. Google Scholar 6 : Optimum sample times for single-injection, multisample renal clearance methods. J Nucl Med1993; 34: 1761. Google Scholar 7 : 125Iodine-iothalamate clearance in children. A simple method to measure glomerular filtration. Pediatr Nephrol1996; 10: 25. Google Scholar 8 : Niedermolekulare Proteine im Serum als Marker der glomerulären Filtrationsrate: Cystatin C, α-1-Mikroglobulin und β-2-Mikroglobulin. Lab Med1994; 18: 461. Google Scholar 9 : Assessment of renal function in renal transplant patients using cystatin C. A comparison to other renal function markers and estimates. Ren Fail2001; 23: 439. Google Scholar 10 : Cystatin C—properties and use as diagnostic marker. Adv Clin Chem2000; 35: 63. Google Scholar 11 : Beta-trace protein in serum: a new marker of glomerular filtration rate in the creatinine-blind range. Clin Chem1999; 45: 567. Google Scholar 12 : Molecular characterization of beta-trace protein in human serum and urine: a potential diagnostic marker for renal diseases. Glycobiology1997; 7: 499. Google Scholar 13 : Cystatin C—a new marker of glomerular filtration rate in children independent of age and height. Pediatrics1998; 101: 875. Google Scholar 14 : Relationships among serum cystatin C, serum creatinine, lean tissue mass and glomerular filtration rate in healthy adults. Scand J Clin Lab Invest1999; 59: 587. Google Scholar 15 : Optimum sample times for single-injection, multisample renal clearance methods. J Nucl Med1993; 34: 1761. Google Scholar 16 : The use of plasma creatinine concentration for estimating glomerular filtration rate in infants, children and adolescents. Pediatr Clin North Am1987; 34: 571. Google Scholar 17 : Receiver-operating characteristic (ROC) plots: a fundamental evaluation tool in clinical medicine. Clin Chem1993; 39: 561. Google Scholar 18 : Relationship of asymptomatic bacteriuria and renal scarring in children with neuropathic bladders who are practicing clean intermittent catheterization. J Pediatr1995; 127: 368. Google Scholar 19 : Assessment of obesity of children with spina bifida. Dev Med Child Neurol1993; 35: 305. Google Scholar 20 : Beta-trace protein, cystatin C, beta(2)-microglobulin, and creatinine compared for detecting impaired glomerular filtration rates in children. Clin Chem2002; 48: 729. Google Scholar From the Department of Surgery, Division of Urology, and Departments of Pediatrics, and Pathology and Laboratory Medicine, Children’s Hospital of Eastern Ontario, University of Ottawa, Ottawa, Ontario, Canada© 2003 by American Urological Association, Inc.FiguresReferencesRelatedDetailsCited byRague J, Lai J, Murphy P, Fawcett A, Walton R, Rosoklija I, Bowen D, Yerkes E, Cheng E, Hodgkins K, Routh J, Isakova T and Chu D (2022) Variation in Definitions of Kidney Abnormality in Patients with Spina Bifida: A Systematic Scoping ReviewJournal of Urology, VOL. 207, NO. 6, (1184-1192), Online publication date: 1-Jun-2022.Corrao A, Lisi G, Di Pasqua G, Guizzardi M, Marino N, Ballone E and Lelli Chiesa P (2018) Serum Cystatin C as a Reliable Marker of Changes in Glomerular Filtration Rate in Children With Urinary Tract MalformationsJournal of Urology, VOL. 175, NO. 1, (303-309), Online publication date: 1-Jan-2006.Rao A, Plail R, Motiwala H and Karim O (2018) RE: IS BENIGN PROSTATIC HYPERPLASIA A RISK FACTOR FOR CHRONIC RENAL FAILURE?Journal of Urology, VOL. 174, NO. 6, (2427-2428), Online publication date: 1-Dec-2005. Volume 169Issue 6June 2003Page: 2312-2315 Advertisement Copyright & Permissions© 2003 by American Urological Association, Inc.Keywordscreatinine/bloodmuscle, skeletalbiological markersspinal dysraphismMetricsAuthor Information ANNE PHAM-HUY More articles by this author MICHAEL LEONARD Financial interest and/or other relationship with Pharmacia. More articles by this author NATHALIE LEPAGE More articles by this author JACQUELINE HALTON More articles by this author GUIDO FILLER More articles by this author Expand All Advertisement PDF downloadLoading ..." @default.
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- W1975296948 title "Measuring Glomerular Filtration Rate with Cystatin C and β-Trace Protein in Children with Spina Bifida" @default.
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