Matches in SemOpenAlex for { <https://semopenalex.org/work/W1975325583> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W1975325583 endingPage "395" @default.
- W1975325583 startingPage "389" @default.
- W1975325583 abstract "Abstract— The aim of this study was to compare red (652 nm) and green (514 nm) light for photodynamic therapy (PDT) of the peritoneal cavity with emphasis on light distribution and toxicity. Red-light PDT was limited by intestinal toxicity and it was hypothesized that less penetrating green light would allow higher light doses to be used in the peritoneal cavity. Female non-tumor-bearing rats were photosensitized with mTHPC (meta-tetrahydroxyphenylchlorin, Foscan®) intravenously or intraperitoneally and the peritoneum was illuminated using a minimally invasive technique. For both red and green light, the time of illumination was varied to give the required dose. Light fluence rate was measured in situ at multiple sites within the abdominal cavity. The toxicity experiments were carried out with a total of 160 J incident red or 640 J incident green light and a drug dose of 0.15 mg/kg Foscan® For red light a mean fluence rate of 55.2 38.5 mW cm 2 was measured, with a peak fluence rate of 128 mW cm 2 on the intestines. For green light the mean and peak fluence rates were 8.2 9.0 (i.e. including zero fluence rate measurements) and 28 mW cm 2, respectively. Intestines were most vulnerable to red light illumination. The intravenous injection route resulted in increased toxicity for red light, but for green light there were no major differences between intravenous and intraperitoneal routes. The 4 h interval between drug and illumination resulted in very little toxicity for both wavelengths. We conclude that for intraperitoneal PDT green light allows higher light doses than red light, but the light distribution over the peritoneum is much less favorable and may not be suitable for whole peritoneal illumination using a minimal-access technique." @default.
- W1975325583 created "2016-06-24" @default.
- W1975325583 creator A5015292429 @default.
- W1975325583 creator A5021933506 @default.
- W1975325583 creator A5035920436 @default.
- W1975325583 creator A5040309636 @default.
- W1975325583 creator A5049054020 @default.
- W1975325583 creator A5051560890 @default.
- W1975325583 creator A5056958833 @default.
- W1975325583 creator A5062981502 @default.
- W1975325583 date "1997-09-01" @default.
- W1975325583 modified "2023-10-03" @default.
- W1975325583 title "Intraperitoneal Photodynamic Therapy: Comparison of Red and Green Light Distribution and Toxicity" @default.
- W1975325583 cites W1771776794 @default.
- W1975325583 cites W1965935539 @default.
- W1975325583 cites W1971303540 @default.
- W1975325583 cites W1974712046 @default.
- W1975325583 cites W1985757402 @default.
- W1975325583 cites W2009553104 @default.
- W1975325583 cites W2043719306 @default.
- W1975325583 cites W2075197298 @default.
- W1975325583 cites W2087138789 @default.
- W1975325583 cites W2088487264 @default.
- W1975325583 cites W2096511699 @default.
- W1975325583 cites W2127721767 @default.
- W1975325583 cites W2162372312 @default.
- W1975325583 doi "https://doi.org/10.1111/j.1751-1097.1997.tb03163.x" @default.
- W1975325583 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9297983" @default.
- W1975325583 hasPublicationYear "1997" @default.
- W1975325583 type Work @default.
- W1975325583 sameAs 1975325583 @default.
- W1975325583 citedByCount "15" @default.
- W1975325583 countsByYear W19753255832012 @default.
- W1975325583 countsByYear W19753255832014 @default.
- W1975325583 countsByYear W19753255832015 @default.
- W1975325583 countsByYear W19753255832017 @default.
- W1975325583 crossrefType "journal-article" @default.
- W1975325583 hasAuthorship W1975325583A5015292429 @default.
- W1975325583 hasAuthorship W1975325583A5021933506 @default.
- W1975325583 hasAuthorship W1975325583A5035920436 @default.
- W1975325583 hasAuthorship W1975325583A5040309636 @default.
- W1975325583 hasAuthorship W1975325583A5049054020 @default.
- W1975325583 hasAuthorship W1975325583A5051560890 @default.
- W1975325583 hasAuthorship W1975325583A5056958833 @default.
- W1975325583 hasAuthorship W1975325583A5062981502 @default.
- W1975325583 hasConcept C104663316 @default.
- W1975325583 hasConcept C116263406 @default.
- W1975325583 hasConcept C141071460 @default.
- W1975325583 hasConcept C178790620 @default.
- W1975325583 hasConcept C185592680 @default.
- W1975325583 hasConcept C192562407 @default.
- W1975325583 hasConcept C2775987729 @default.
- W1975325583 hasConcept C2778536324 @default.
- W1975325583 hasConcept C2781323092 @default.
- W1975325583 hasConcept C29730261 @default.
- W1975325583 hasConcept C2986477067 @default.
- W1975325583 hasConcept C2989005 @default.
- W1975325583 hasConcept C49040817 @default.
- W1975325583 hasConcept C59822182 @default.
- W1975325583 hasConcept C71924100 @default.
- W1975325583 hasConcept C86803240 @default.
- W1975325583 hasConceptScore W1975325583C104663316 @default.
- W1975325583 hasConceptScore W1975325583C116263406 @default.
- W1975325583 hasConceptScore W1975325583C141071460 @default.
- W1975325583 hasConceptScore W1975325583C178790620 @default.
- W1975325583 hasConceptScore W1975325583C185592680 @default.
- W1975325583 hasConceptScore W1975325583C192562407 @default.
- W1975325583 hasConceptScore W1975325583C2775987729 @default.
- W1975325583 hasConceptScore W1975325583C2778536324 @default.
- W1975325583 hasConceptScore W1975325583C2781323092 @default.
- W1975325583 hasConceptScore W1975325583C29730261 @default.
- W1975325583 hasConceptScore W1975325583C2986477067 @default.
- W1975325583 hasConceptScore W1975325583C2989005 @default.
- W1975325583 hasConceptScore W1975325583C49040817 @default.
- W1975325583 hasConceptScore W1975325583C59822182 @default.
- W1975325583 hasConceptScore W1975325583C71924100 @default.
- W1975325583 hasConceptScore W1975325583C86803240 @default.
- W1975325583 hasIssue "3" @default.
- W1975325583 hasLocation W19753255831 @default.
- W1975325583 hasLocation W19753255832 @default.
- W1975325583 hasOpenAccess W1975325583 @default.
- W1975325583 hasPrimaryLocation W19753255831 @default.
- W1975325583 hasRelatedWork W1509039278 @default.
- W1975325583 hasRelatedWork W1968534234 @default.
- W1975325583 hasRelatedWork W1975325583 @default.
- W1975325583 hasRelatedWork W2019566319 @default.
- W1975325583 hasRelatedWork W2036527359 @default.
- W1975325583 hasRelatedWork W2121562669 @default.
- W1975325583 hasRelatedWork W2130500038 @default.
- W1975325583 hasRelatedWork W2166466007 @default.
- W1975325583 hasRelatedWork W2389983864 @default.
- W1975325583 hasRelatedWork W2399603722 @default.
- W1975325583 hasVolume "66" @default.
- W1975325583 isParatext "false" @default.
- W1975325583 isRetracted "false" @default.
- W1975325583 magId "1975325583" @default.
- W1975325583 workType "article" @default.