Matches in SemOpenAlex for { <https://semopenalex.org/work/W1975326767> ?p ?o ?g. }
- W1975326767 endingPage "1866" @default.
- W1975326767 startingPage "1857" @default.
- W1975326767 abstract "The macrophage mannose receptor (MR) has an established role in the phagocytosis of a wide range of microbes, and also functions in viral endocytosis, and clearance of a number of endogenous glycoproteins from the circulation. Its broad ligand specificity is mediated by tandemly linked carbohydrate recognition domains (CRDs). Recent studies suggest that binding or internalization of both natural and synthetic ligands of MR CRDs may modulate macrophage (MPhi ) function, for example to increase cidal capacity or cytokine synthesis. To identify endogenous ligands in the normal mouse we used an Fc-fusion protein (CRD4-7Fc) bearing four of the CRDs of MR. CRD4-7Fc recognized endocytic compartments of cultured MPhi, consistent with lysosomal enzymes being major ligands of MR. CRD4-7Fc also recognized MPhi and some endothelial cells in tissues, and intensely labeled secretory cells of the exocrine pancreas, salivary gland and thyroid. Strongly MR-positive interstitial cells were found in close proximity to the ligand-rich secretory cells, suggesting a role for MR in uptake of secretory glycoproteins, including thyroglobulin which was identified as a novel ligand in vitro. Endocytosis of these ligands by MR may have implications for tissue homeostasis and immunity, including antigen presentation, in secretory organs." @default.
- W1975326767 created "2016-06-24" @default.
- W1975326767 creator A5030623385 @default.
- W1975326767 creator A5060388462 @default.
- W1975326767 creator A5077276881 @default.
- W1975326767 creator A5086310960 @default.
- W1975326767 date "2001-06-01" @default.
- W1975326767 modified "2023-10-13" @default.
- W1975326767 title "Endogenous ligands of carbohydrate recognition domains of the mannose receptor in murine macrophages, endothelial cells and secretory cells; potential relevance to inflammation and immunity" @default.
- W1975326767 cites W1423560049 @default.
- W1975326767 cites W1497488811 @default.
- W1975326767 cites W1526287730 @default.
- W1975326767 cites W1533530009 @default.
- W1975326767 cites W1540076991 @default.
- W1975326767 cites W1543454781 @default.
- W1975326767 cites W1554807780 @default.
- W1975326767 cites W1555196812 @default.
- W1975326767 cites W1576284636 @default.
- W1975326767 cites W1588226764 @default.
- W1975326767 cites W1612151898 @default.
- W1975326767 cites W1873981281 @default.
- W1975326767 cites W1938170556 @default.
- W1975326767 cites W1972714115 @default.
- W1975326767 cites W1973238005 @default.
- W1975326767 cites W1974775242 @default.
- W1975326767 cites W1978105709 @default.
- W1975326767 cites W1984995468 @default.
- W1975326767 cites W1990219949 @default.
- W1975326767 cites W1992945910 @default.
- W1975326767 cites W1998733027 @default.
- W1975326767 cites W2002122771 @default.
- W1975326767 cites W2003042213 @default.
- W1975326767 cites W2007958535 @default.
- W1975326767 cites W2013857975 @default.
- W1975326767 cites W2014324389 @default.
- W1975326767 cites W2024518999 @default.
- W1975326767 cites W2040283218 @default.
- W1975326767 cites W2054763407 @default.
- W1975326767 cites W2065871536 @default.
- W1975326767 cites W2067343649 @default.
- W1975326767 cites W2070413100 @default.
- W1975326767 cites W2090667112 @default.
- W1975326767 cites W2094360785 @default.
- W1975326767 cites W2103147774 @default.
- W1975326767 cites W2104633821 @default.
- W1975326767 cites W2111695773 @default.
- W1975326767 cites W2120380490 @default.
- W1975326767 cites W2126638296 @default.
- W1975326767 cites W2127648758 @default.
- W1975326767 cites W2130506001 @default.
- W1975326767 cites W2131424376 @default.
- W1975326767 cites W2135079499 @default.
- W1975326767 cites W2148619935 @default.
- W1975326767 cites W2159750834 @default.
- W1975326767 cites W2223484267 @default.
- W1975326767 cites W2460284700 @default.
- W1975326767 doi "https://doi.org/10.1002/1521-4141(200106)31:6<1857::aid-immu1857>3.0.co;2-d" @default.
- W1975326767 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11433382" @default.
- W1975326767 hasPublicationYear "2001" @default.
- W1975326767 type Work @default.
- W1975326767 sameAs 1975326767 @default.
- W1975326767 citedByCount "80" @default.
- W1975326767 countsByYear W19753267672012 @default.
- W1975326767 countsByYear W19753267672013 @default.
- W1975326767 countsByYear W19753267672014 @default.
- W1975326767 countsByYear W19753267672015 @default.
- W1975326767 countsByYear W19753267672017 @default.
- W1975326767 countsByYear W19753267672018 @default.
- W1975326767 countsByYear W19753267672019 @default.
- W1975326767 countsByYear W19753267672020 @default.
- W1975326767 countsByYear W19753267672021 @default.
- W1975326767 countsByYear W19753267672022 @default.
- W1975326767 countsByYear W19753267672023 @default.
- W1975326767 crossrefType "journal-article" @default.
- W1975326767 hasAuthorship W1975326767A5030623385 @default.
- W1975326767 hasAuthorship W1975326767A5060388462 @default.
- W1975326767 hasAuthorship W1975326767A5077276881 @default.
- W1975326767 hasAuthorship W1975326767A5086310960 @default.
- W1975326767 hasBestOaLocation W19753267671 @default.
- W1975326767 hasConcept C139770010 @default.
- W1975326767 hasConcept C170493617 @default.
- W1975326767 hasConcept C202751555 @default.
- W1975326767 hasConcept C2776205754 @default.
- W1975326767 hasConcept C2779244956 @default.
- W1975326767 hasConcept C28005876 @default.
- W1975326767 hasConcept C55493867 @default.
- W1975326767 hasConcept C79747257 @default.
- W1975326767 hasConcept C86803240 @default.
- W1975326767 hasConcept C95444343 @default.
- W1975326767 hasConceptScore W1975326767C139770010 @default.
- W1975326767 hasConceptScore W1975326767C170493617 @default.
- W1975326767 hasConceptScore W1975326767C202751555 @default.
- W1975326767 hasConceptScore W1975326767C2776205754 @default.
- W1975326767 hasConceptScore W1975326767C2779244956 @default.
- W1975326767 hasConceptScore W1975326767C28005876 @default.
- W1975326767 hasConceptScore W1975326767C55493867 @default.
- W1975326767 hasConceptScore W1975326767C79747257 @default.
- W1975326767 hasConceptScore W1975326767C86803240 @default.