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Matches in SemOpenAlex for { <https://semopenalex.org/work/W1975338049> ?p ?o ?g. }

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• W1975338049 abstract "Members of the microRNA-29 (miR-29) family directly target the DNA methyltransferases, DNMT3A and DNMT3B. Disturbances in the expression levels of miR-29 have been linked to tumorigenesis and tumor aggressiveness. Members of the miR-29 family are currently thought to repress DNA methylation and suppress tumorigenesis by protecting against de novo methylation. Here, we report that members of the miR-29 family repress the activities of DNA methyltransferases and DNA demethylases, which have opposing roles in control of DNA methylation status. Members of the miR-29 family directly inhibited DNA methyltransferases and two major factors involved in DNA demethylation, namely tet methylcytosine dioxygenase 1 (TET1) and thymine DNA glycosylase (TDG). Overexpression of miR-29 upregulated the global DNA methylation level in some cancer cells and downregulated DNA methylation in other cancer cells, suggesting that miR-29 suppresses tumorigenesis by protecting against changes in the existing DNA methylation status rather than by preventing de novo methylation of DNA." @default.
• W1975338049 created "2016-06-24" @default.
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• W1975338049 date "2013-07-12" @default.
• W1975338049 modified "2023-10-03" @default.
• W1975338049 title "miR-29 Represses the Activities of DNA Methyltransferases and DNA Demethylases" @default.
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• W1975338049 doi "https://doi.org/10.3390/ijms140714647" @default.
• W1975338049 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3742264" @default.
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