Matches in SemOpenAlex for { <https://semopenalex.org/work/W1975342489> ?p ?o ?g. }
- W1975342489 endingPage "6786" @default.
- W1975342489 startingPage "6781" @default.
- W1975342489 abstract "The synthesis of γ-lactams that are unsubstituted at the 1-position (nitrogen) as well as their subsequent N-functionalization is reported. A recently discovered four-component reaction (4CR) is employed with either an ammonia precursor or a protected form of ammonia that can be deprotected in a subsequent synthetic step. These methods represent the first multicomponent assembly of complex lactam structures that are unsubstituted at nitrogen. In addition, two methods for the introduction of nitrogen substituents that are not possible through the original 4CR are reported. X-ray crystallographic analysis of representative structures reveals conformational changes in the core structure that will enable future deployment of this chemistry in the design and synthesis of diverse collections of lactams suitable for the discovery of new biological probes." @default.
- W1975342489 created "2016-06-24" @default.
- W1975342489 creator A5027769641 @default.
- W1975342489 creator A5037422038 @default.
- W1975342489 creator A5043371622 @default.
- W1975342489 creator A5082845641 @default.
- W1975342489 date "2011-02-02" @default.
- W1975342489 modified "2023-09-29" @default.
- W1975342489 title "Ammonia synthons for the multicomponent assembly of complex γ-lactams" @default.
- W1975342489 cites W1963684516 @default.
- W1975342489 cites W1970998929 @default.
- W1975342489 cites W1972769823 @default.
- W1975342489 cites W1972936800 @default.
- W1975342489 cites W1984610255 @default.
- W1975342489 cites W1985580893 @default.
- W1975342489 cites W1989568348 @default.
- W1975342489 cites W1990005521 @default.
- W1975342489 cites W1995040561 @default.
- W1975342489 cites W1999087161 @default.
- W1975342489 cites W2012395535 @default.
- W1975342489 cites W2013099099 @default.
- W1975342489 cites W2019580722 @default.
- W1975342489 cites W2021346593 @default.
- W1975342489 cites W2040559769 @default.
- W1975342489 cites W2052978035 @default.
- W1975342489 cites W2053324847 @default.
- W1975342489 cites W2054953645 @default.
- W1975342489 cites W2063022733 @default.
- W1975342489 cites W2066356327 @default.
- W1975342489 cites W2067381428 @default.
- W1975342489 cites W2069251675 @default.
- W1975342489 cites W2074811222 @default.
- W1975342489 cites W2084732909 @default.
- W1975342489 cites W2086855984 @default.
- W1975342489 cites W2088196401 @default.
- W1975342489 cites W2091520039 @default.
- W1975342489 cites W2109398918 @default.
- W1975342489 cites W2110301258 @default.
- W1975342489 cites W2110772195 @default.
- W1975342489 cites W2121151545 @default.
- W1975342489 cites W2127378043 @default.
- W1975342489 cites W2155390912 @default.
- W1975342489 cites W2171513236 @default.
- W1975342489 cites W2319442055 @default.
- W1975342489 cites W2476582390 @default.
- W1975342489 cites W2950812810 @default.
- W1975342489 cites W2951562148 @default.
- W1975342489 cites W2951661129 @default.
- W1975342489 cites W2951887947 @default.
- W1975342489 cites W2952338903 @default.
- W1975342489 cites W2953099525 @default.
- W1975342489 cites W4206256448 @default.
- W1975342489 doi "https://doi.org/10.1073/pnas.1015261108" @default.
- W1975342489 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3084106" @default.
- W1975342489 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21289284" @default.
- W1975342489 hasPublicationYear "2011" @default.
- W1975342489 type Work @default.
- W1975342489 sameAs 1975342489 @default.
- W1975342489 citedByCount "44" @default.
- W1975342489 countsByYear W19753424892012 @default.
- W1975342489 countsByYear W19753424892013 @default.
- W1975342489 countsByYear W19753424892014 @default.
- W1975342489 countsByYear W19753424892015 @default.
- W1975342489 countsByYear W19753424892016 @default.
- W1975342489 countsByYear W19753424892017 @default.
- W1975342489 countsByYear W19753424892019 @default.
- W1975342489 countsByYear W19753424892020 @default.
- W1975342489 countsByYear W19753424892021 @default.
- W1975342489 countsByYear W19753424892022 @default.
- W1975342489 countsByYear W19753424892023 @default.
- W1975342489 crossrefType "journal-article" @default.
- W1975342489 hasAuthorship W1975342489A5027769641 @default.
- W1975342489 hasAuthorship W1975342489A5037422038 @default.
- W1975342489 hasAuthorship W1975342489A5043371622 @default.
- W1975342489 hasAuthorship W1975342489A5082845641 @default.
- W1975342489 hasBestOaLocation W19753424891 @default.
- W1975342489 hasConcept C178790620 @default.
- W1975342489 hasConcept C185592680 @default.
- W1975342489 hasConcept C21951064 @default.
- W1975342489 hasConcept C2776131168 @default.
- W1975342489 hasConcept C2776382133 @default.
- W1975342489 hasConcept C2778617581 @default.
- W1975342489 hasConcept C40869318 @default.
- W1975342489 hasConcept C501593827 @default.
- W1975342489 hasConcept C537208039 @default.
- W1975342489 hasConcept C55493867 @default.
- W1975342489 hasConcept C71240020 @default.
- W1975342489 hasConceptScore W1975342489C178790620 @default.
- W1975342489 hasConceptScore W1975342489C185592680 @default.
- W1975342489 hasConceptScore W1975342489C21951064 @default.
- W1975342489 hasConceptScore W1975342489C2776131168 @default.
- W1975342489 hasConceptScore W1975342489C2776382133 @default.
- W1975342489 hasConceptScore W1975342489C2778617581 @default.
- W1975342489 hasConceptScore W1975342489C40869318 @default.
- W1975342489 hasConceptScore W1975342489C501593827 @default.
- W1975342489 hasConceptScore W1975342489C537208039 @default.
- W1975342489 hasConceptScore W1975342489C55493867 @default.
- W1975342489 hasConceptScore W1975342489C71240020 @default.