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- W1975347029 endingPage "1380" @default.
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- W1975347029 abstract "Odors activate lobster olfactory receptor neurons (ORNs) through phosphoinositide signaling that appears to target a Na(+)-gated nonselective cation channel. The Na(+)-gated channel is a potential member of the growing family of transient receptor potential (TRP) channels. Here, we test the effect of potential antagonists on the channel in cell-free patches from cultured lobster ORNs. We show that the channel is antagonized by H+ and the TRP channel blockers 2-aminoethoxydiphenyl borate, SKF96365, ruthenium red, Al3+, Gd3+, and La3+. We then use this enhanced antagonist profile together with the agonists Na+ and Ca2+ to implicate the channel in signal amplification in the cells." @default.
- W1975347029 created "2016-06-24" @default.
- W1975347029 creator A5041864393 @default.
- W1975347029 creator A5068832085 @default.
- W1975347029 date "2005-03-01" @default.
- W1975347029 modified "2023-10-01" @default.
- W1975347029 title "Pharmacological Properties and Functional Role of a TRP-Related Ion Channel in Lobster Olfactory Receptor Neurons" @default.
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- W1975347029 doi "https://doi.org/10.1152/jn.00990.2004" @default.
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