Matches in SemOpenAlex for { <https://semopenalex.org/work/W1975366486> ?p ?o ?g. }
- W1975366486 endingPage "333" @default.
- W1975366486 startingPage "319" @default.
- W1975366486 abstract "Human monocyte subsets, isolated from cultures of mononuclear cells, or freshly obtained from patients with multiple sclerosis, Graves‘ disease or pemphigus vulgaris, differed in phenotype, apoptotic features, mRNA levels of arginase II (A-II) and the inducible form of nitric oxide synthase (iNOS). Liver-type arginase I mRNA was present in all subsets. Apoptosis was followed by the expression of T cell intracellular antigen (TIA) and the simultaneous detection of DNA stainability by propidium iodine and annexin V binding. Apoptosis was practically absent both in activated CD14++CD33++DR++CD25++CD69++CD71++/+CD16− cells, expressing A-II mRNA and having arginase activity, but not iNOS mRNA, and in not fully mature large CD14++CD16+CD23+DR++ monocytes, expressing simultaneously both mRNAs and having both enzyme activities. However, differentiated small CD14+/++CD16+CD69+CD25+/−CD71++CD23+DR++ monocytes, expressing high levels of iNOS mRNA, exhibited apoptotic signs. Amounts of NO synthesised by monocytes co-expressing iNOS and arginase changed with the addition of arginine or an iNOS inhibitor; in that case a correlation of NO production and apoptotic features was observed. Data suggest a regulatory role for endogenous NO in apoptosis of stimulated and differentiated monocytes, and also that iNOS and A-II, when simultaneously present, could control the production of NO as a consequence of their competition for arginine." @default.
- W1975366486 created "2016-06-24" @default.
- W1975366486 creator A5051393923 @default.
- W1975366486 creator A5051925857 @default.
- W1975366486 creator A5061146491 @default.
- W1975366486 creator A5064771070 @default.
- W1975366486 creator A5074817923 @default.
- W1975366486 creator A5078469152 @default.
- W1975366486 creator A5079519356 @default.
- W1975366486 date "1999-09-01" @default.
- W1975366486 modified "2023-09-28" @default.
- W1975366486 title "Co-expression of inducible nitric oxide synthase and arginases in different human monocyte subsets. Apoptosis regulated by endogenous NO" @default.
- W1975366486 cites W1557119871 @default.
- W1975366486 cites W1596698400 @default.
- W1975366486 cites W1645271434 @default.
- W1975366486 cites W1748048801 @default.
- W1975366486 cites W1781555612 @default.
- W1975366486 cites W1921197836 @default.
- W1975366486 cites W1964072966 @default.
- W1975366486 cites W1984188855 @default.
- W1975366486 cites W1985095303 @default.
- W1975366486 cites W1988465894 @default.
- W1975366486 cites W1989219781 @default.
- W1975366486 cites W2003106613 @default.
- W1975366486 cites W2004658589 @default.
- W1975366486 cites W2005271042 @default.
- W1975366486 cites W2014588425 @default.
- W1975366486 cites W2015192504 @default.
- W1975366486 cites W2020184138 @default.
- W1975366486 cites W2020818523 @default.
- W1975366486 cites W2021864452 @default.
- W1975366486 cites W2026125174 @default.
- W1975366486 cites W2028505614 @default.
- W1975366486 cites W2029434044 @default.
- W1975366486 cites W2036160471 @default.
- W1975366486 cites W2042717381 @default.
- W1975366486 cites W2054191900 @default.
- W1975366486 cites W2073803432 @default.
- W1975366486 cites W2074443913 @default.
- W1975366486 cites W2078796742 @default.
- W1975366486 cites W2080567147 @default.
- W1975366486 cites W2087614633 @default.
- W1975366486 cites W2091675805 @default.
- W1975366486 cites W2104032278 @default.
- W1975366486 cites W2110530182 @default.
- W1975366486 cites W2113694345 @default.
- W1975366486 cites W2124748247 @default.
- W1975366486 cites W2137495367 @default.
- W1975366486 cites W2165389027 @default.
- W1975366486 cites W2170320784 @default.
- W1975366486 cites W2320556745 @default.
- W1975366486 cites W4313323083 @default.
- W1975366486 doi "https://doi.org/10.1016/s0167-4889(99)00106-8" @default.
- W1975366486 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10556586" @default.
- W1975366486 hasPublicationYear "1999" @default.
- W1975366486 type Work @default.
- W1975366486 sameAs 1975366486 @default.
- W1975366486 citedByCount "37" @default.
- W1975366486 countsByYear W19753664862012 @default.
- W1975366486 countsByYear W19753664862014 @default.
- W1975366486 countsByYear W19753664862016 @default.
- W1975366486 countsByYear W19753664862017 @default.
- W1975366486 countsByYear W19753664862020 @default.
- W1975366486 countsByYear W19753664862021 @default.
- W1975366486 countsByYear W19753664862023 @default.
- W1975366486 crossrefType "journal-article" @default.
- W1975366486 hasAuthorship W1975366486A5051393923 @default.
- W1975366486 hasAuthorship W1975366486A5051925857 @default.
- W1975366486 hasAuthorship W1975366486A5061146491 @default.
- W1975366486 hasAuthorship W1975366486A5064771070 @default.
- W1975366486 hasAuthorship W1975366486A5074817923 @default.
- W1975366486 hasAuthorship W1975366486A5078469152 @default.
- W1975366486 hasAuthorship W1975366486A5079519356 @default.
- W1975366486 hasBestOaLocation W19753664861 @default.
- W1975366486 hasConcept C114684123 @default.
- W1975366486 hasConcept C134018914 @default.
- W1975366486 hasConcept C153911025 @default.
- W1975366486 hasConcept C164007495 @default.
- W1975366486 hasConcept C167672396 @default.
- W1975366486 hasConcept C185592680 @default.
- W1975366486 hasConcept C190283241 @default.
- W1975366486 hasConcept C203014093 @default.
- W1975366486 hasConcept C2777468819 @default.
- W1975366486 hasConcept C2777622882 @default.
- W1975366486 hasConcept C2778513237 @default.
- W1975366486 hasConcept C2781462264 @default.
- W1975366486 hasConcept C515207424 @default.
- W1975366486 hasConcept C519581460 @default.
- W1975366486 hasConcept C553184892 @default.
- W1975366486 hasConcept C55493867 @default.
- W1975366486 hasConcept C86803240 @default.
- W1975366486 hasConcept C8891405 @default.
- W1975366486 hasConceptScore W1975366486C114684123 @default.
- W1975366486 hasConceptScore W1975366486C134018914 @default.
- W1975366486 hasConceptScore W1975366486C153911025 @default.
- W1975366486 hasConceptScore W1975366486C164007495 @default.
- W1975366486 hasConceptScore W1975366486C167672396 @default.
- W1975366486 hasConceptScore W1975366486C185592680 @default.