FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1975367003> ?p ?o ?g. }

• W1975367003 endingPage "446" @default.
• W1975367003 startingPage "440" @default.
• W1975367003 abstract "Although it is known that after major tissue trauma, local incidents in the mechanically destroyed muscle tissue form the basis of subsequently occurring severe inflammatory reactions, the very first events taking place immediately after myocyte destruction have not been studied on the single cell level thus far. Therefore, in this study, the reaction of cultured C2C12 mouse skeletal myocytes to lethal injury was examined using laser scanning microscopy. Mechanical rupture of one single myocyte induced an immediate accumulation of calcium in its cytosol and nuclei, as detected by an increase in the fluorescence intensity of the intracellular calcium-sensitive dye Fluo-3. The intracellular calcium elevation propagated further to the adjacent, noninjured myocytes in a wave-like fashion within seconds. The calcium increase detected in these neighboring cells was higher and up to 1000 times more extended than the physiological calcium spike that induces C2C12 myocyte contraction. Wave propagation did not depend on gap junctional communication but occurred via liberation of nucleotides, mainly ATP, but presumably also UTP and others, from the destroyed cell and subsequent calcium release from the sarcoplasmic reticulum via a purinoceptor-mediated mechanism in the adjacent cells. These findings suggest a decisive role of ATP and related nucleotides in the pathogenesis of tissue trauma because they appear to initiate the signaling mechanism from injured myocytes to the surrounding tissue and potentially to the whole body." @default.
• W1975367003 created "2016-06-24" @default.
• W1975367003 creator A5040387308 @default.
• W1975367003 creator A5072963432 @default.
• W1975367003 date "2005-11-01" @default.
• W1975367003 modified "2023-09-26" @default.
• W1975367003 title "ATP-INDUCED CALCIUM INCREASE AS A POTENTIAL FIRST SIGNAL IN MECHANICAL TISSUE TRAUMA. A LASER SCANNING MICROSCOPIC STUDY ON CULTURED MOUSE SKELETAL MYOCYTES" @default.
• W1975367003 cites W1529590189 @default.
• W1975367003 cites W1591339234 @default.
• W1975367003 cites W1784820495 @default.
• W1975367003 cites W1896694293 @default.
• W1975367003 cites W1947888345 @default.
• W1975367003 cites W1963503219 @default.
• W1975367003 cites W1967884571 @default.
• W1975367003 cites W1980166477 @default.
• W1975367003 cites W1986437824 @default.
• W1975367003 cites W1988712593 @default.
• W1975367003 cites W1993239728 @default.
• W1975367003 cites W1996628093 @default.
• W1975367003 cites W2000721979 @default.
• W1975367003 cites W2013897693 @default.
• W1975367003 cites W2014543453 @default.
• W1975367003 cites W2019329906 @default.
• W1975367003 cites W2021701449 @default.
• W1975367003 cites W2021709361 @default.
• W1975367003 cites W2022933031 @default.
• W1975367003 cites W2036648910 @default.
• W1975367003 cites W2038198407 @default.
• W1975367003 cites W2059880723 @default.
• W1975367003 cites W2074290309 @default.
• W1975367003 cites W2074618631 @default.
• W1975367003 cites W2078327779 @default.
• W1975367003 cites W2082701559 @default.
• W1975367003 cites W2088070024 @default.
• W1975367003 cites W2103183026 @default.
• W1975367003 cites W2112634056 @default.
• W1975367003 cites W2128748529 @default.
• W1975367003 cites W2145038407 @default.
• W1975367003 cites W2162126409 @default.
• W1975367003 cites W2185840810 @default.
• W1975367003 cites W2337937663 @default.
• W1975367003 cites W2341210013 @default.
• W1975367003 cites W2412821688 @default.
• W1975367003 cites W2011947383 @default.
• W1975367003 doi "https://doi.org/10.1097/01.shk.0000176185.89793.05" @default.
• W1975367003 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16247330" @default.
• W1975367003 hasPublicationYear "2005" @default.
• W1975367003 type Work @default.
• W1975367003 sameAs 1975367003 @default.
• W1975367003 citedByCount "5" @default.
• W1975367003 countsByYear W19753670032012 @default.
• W1975367003 crossrefType "journal-article" @default.
• W1975367003 hasAuthorship W1975367003A5040387308 @default.
• W1975367003 hasAuthorship W1975367003A5072963432 @default.
• W1975367003 hasBestOaLocation W19753670031 @default.
• W1975367003 hasConcept C105702510 @default.
• W1975367003 hasConcept C12554922 @default.
• W1975367003 hasConcept C126322002 @default.
• W1975367003 hasConcept C134018914 @default.
• W1975367003 hasConcept C158617107 @default.
• W1975367003 hasConcept C163415756 @default.
• W1975367003 hasConcept C181080969 @default.
• W1975367003 hasConcept C181199279 @default.
• W1975367003 hasConcept C185592680 @default.
• W1975367003 hasConcept C201571599 @default.
• W1975367003 hasConcept C207200792 @default.
• W1975367003 hasConcept C2779959927 @default.
• W1975367003 hasConcept C3763915 @default.
• W1975367003 hasConcept C519063684 @default.
• W1975367003 hasConcept C55493867 @default.
• W1975367003 hasConcept C60278653 @default.
• W1975367003 hasConcept C71924100 @default.
• W1975367003 hasConcept C79879829 @default.
• W1975367003 hasConcept C86803240 @default.
• W1975367003 hasConcept C95444343 @default.
• W1975367003 hasConcept C98539663 @default.
• W1975367003 hasConceptScore W1975367003C105702510 @default.
• W1975367003 hasConceptScore W1975367003C12554922 @default.
• W1975367003 hasConceptScore W1975367003C126322002 @default.
• W1975367003 hasConceptScore W1975367003C134018914 @default.
• W1975367003 hasConceptScore W1975367003C158617107 @default.
• W1975367003 hasConceptScore W1975367003C163415756 @default.
• W1975367003 hasConceptScore W1975367003C181080969 @default.
• W1975367003 hasConceptScore W1975367003C181199279 @default.
• W1975367003 hasConceptScore W1975367003C185592680 @default.
• W1975367003 hasConceptScore W1975367003C201571599 @default.
• W1975367003 hasConceptScore W1975367003C207200792 @default.
• W1975367003 hasConceptScore W1975367003C2779959927 @default.
• W1975367003 hasConceptScore W1975367003C3763915 @default.
• W1975367003 hasConceptScore W1975367003C519063684 @default.
• W1975367003 hasConceptScore W1975367003C55493867 @default.
• W1975367003 hasConceptScore W1975367003C60278653 @default.
• W1975367003 hasConceptScore W1975367003C71924100 @default.
• W1975367003 hasConceptScore W1975367003C79879829 @default.
• W1975367003 hasConceptScore W1975367003C86803240 @default.
• W1975367003 hasConceptScore W1975367003C95444343 @default.
• W1975367003 hasConceptScore W1975367003C98539663 @default.
• W1975367003 hasIssue "5" @default.

• next