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- W1975369565 abstract "During self-limiting acute rejection preceding chronic vasculopathy, large amounts of leukocytes, predominantly monocytes , interact with the endothelium of renal allografts . We aim to characterize them and to identify targets for functional and interventional studies. Leukocytes were harvested by vascular perfusion from Fischer 344 to Lewis renal allografts or Lewis isografts , followed by flow cytometry, quantitative RT-PCR and genome-wide transcriptional profiling . Leukocyte accumulation peaked in allografts on day 9. The percentage of monocytes expressing MHC class II and CD161 was increased whereas CD4, CD11a , CD43 , and CD71 expression remained unchanged. IFN-γ, IL-1β, IL-2, IL-10, TNF-α, and iNOS mRNA increased in allograft leukocytes but IL-4, IL-6, IL-12, TGF-β, and tissue factor did not. During acute rejection, 1783 genes were differentially expressed. In conclusion, graft blood leukocytes display a unique state of partial activation during self-limiting rejection. Numerous differentially expressed genes deserve further investigation as potential factors in deciding the fate of the allograft." @default.
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- W1975369565 date "2011-05-01" @default.
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- W1975369565 title "Leukocyte accumulation in graft blood vessels during self-limiting acute rejection of rat kidneys" @default.
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- W1975369565 doi "https://doi.org/10.1016/j.imbio.2010.09.009" @default.
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