FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1975377584> ?p ?o ?g. }

• W1975377584 endingPage "5814" @default.
• W1975377584 startingPage "5805" @default.
• W1975377584 abstract "The identification of in vivo secreted proteins is a major challenge in systems biology. Here we report a novel technique using capillary ultrafiltration (CUF) probes to identify the secreted proteins involved in wound healing. CUF probes, which use semipermeable membrane hollow fibers to continuously capture secreted proteins, were used to sample skin wound fluids. To identify low-abundance proteins, we digested the CUF probe-collected wound fluid with trypsin and then directly subjected it to MS without using 2-DE separation. Two protein fragments with masses of 1565.7 and 1694.8 Da were identified by MS as peptides of thymosin β10 and β4, respectively. This is the first identification of thymosin β10 as an in vivo constituent of the skin wound fluid. The LKKTETQ peptide, a common actin-binding domain of thymosin β4 and β10, significantly enhanced skin wound healing in vitro and in vivo. Our data suggest that the enhancement of wound healing by LKKTETQ may be mediated by purinergic receptors. The technique of using CUF probes linked to mass spectrometric proteomics represents a powerful method to identify in vivo secreted proteins, and may be applicable for identification of proteins relevant in various human diseases." @default.
• W1975377584 created "2016-06-24" @default.
• W1975377584 creator A5011003263 @default.
• W1975377584 creator A5040150010 @default.
• W1975377584 creator A5051982352 @default.
• W1975377584 creator A5069284077 @default.
• W1975377584 date "2006-11-01" @default.
• W1975377584 modified "2023-09-27" @default.
• W1975377584 title "In vivo detection of secreted proteins from wounded skin using capillary ultrafiltration probes and mass spectrometric proteomics" @default.
• W1975377584 cites W1603445298 @default.
• W1975377584 cites W1937470719 @default.
• W1975377584 cites W1949238489 @default.
• W1975377584 cites W1968091639 @default.
• W1975377584 cites W1969078964 @default.
• W1975377584 cites W2004720895 @default.
• W1975377584 cites W2008747758 @default.
• W1975377584 cites W2010461365 @default.
• W1975377584 cites W2015967664 @default.
• W1975377584 cites W2017819318 @default.
• W1975377584 cites W2017988613 @default.
• W1975377584 cites W2019158204 @default.
• W1975377584 cites W2028950342 @default.
• W1975377584 cites W2029370707 @default.
• W1975377584 cites W2041458422 @default.
• W1975377584 cites W2044201339 @default.
• W1975377584 cites W2048284640 @default.
• W1975377584 cites W2051980621 @default.
• W1975377584 cites W2059654891 @default.
• W1975377584 cites W2059660754 @default.
• W1975377584 cites W2064564846 @default.
• W1975377584 cites W2068952881 @default.
• W1975377584 cites W2069779724 @default.
• W1975377584 cites W2070002577 @default.
• W1975377584 cites W2070584689 @default.
• W1975377584 cites W2082073167 @default.
• W1975377584 cites W2085652152 @default.
• W1975377584 cites W2087204196 @default.
• W1975377584 cites W2087544484 @default.
• W1975377584 cites W2088190721 @default.
• W1975377584 cites W2088646459 @default.
• W1975377584 cites W2095588856 @default.
• W1975377584 cites W2104642474 @default.
• W1975377584 cites W2113565576 @default.
• W1975377584 cites W2120734978 @default.
• W1975377584 cites W2122442686 @default.
• W1975377584 cites W2133998224 @default.
• W1975377584 cites W2134782683 @default.
• W1975377584 cites W2158344786 @default.
• W1975377584 cites W2162594584 @default.
• W1975377584 cites W2167636186 @default.
• W1975377584 cites W2171429513 @default.
• W1975377584 cites W2341210013 @default.
• W1975377584 cites W2906899004 @default.
• W1975377584 cites W4293248942 @default.
• W1975377584 cites W49412908 @default.
• W1975377584 cites W1990137578 @default.
• W1975377584 doi "https://doi.org/10.1002/pmic.200600163" @default.
• W1975377584 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17001601" @default.
• W1975377584 hasPublicationYear "2006" @default.
• W1975377584 type Work @default.
• W1975377584 sameAs 1975377584 @default.
• W1975377584 citedByCount "45" @default.
• W1975377584 countsByYear W19753775842012 @default.
• W1975377584 countsByYear W19753775842013 @default.
• W1975377584 countsByYear W19753775842016 @default.
• W1975377584 countsByYear W19753775842017 @default.
• W1975377584 countsByYear W19753775842019 @default.
• W1975377584 countsByYear W19753775842020 @default.
• W1975377584 countsByYear W19753775842023 @default.
• W1975377584 crossrefType "journal-article" @default.
• W1975377584 hasAuthorship W1975377584A5011003263 @default.
• W1975377584 hasAuthorship W1975377584A5040150010 @default.
• W1975377584 hasAuthorship W1975377584A5051982352 @default.
• W1975377584 hasAuthorship W1975377584A5069284077 @default.
• W1975377584 hasConcept C104317684 @default.
• W1975377584 hasConcept C150903083 @default.
• W1975377584 hasConcept C153911025 @default.
• W1975377584 hasConcept C181199279 @default.
• W1975377584 hasConcept C185592680 @default.
• W1975377584 hasConcept C203014093 @default.
• W1975377584 hasConcept C207001950 @default.
• W1975377584 hasConcept C2780269544 @default.
• W1975377584 hasConcept C2780340462 @default.
• W1975377584 hasConcept C46111723 @default.
• W1975377584 hasConcept C50817676 @default.
• W1975377584 hasConcept C55493867 @default.
• W1975377584 hasConcept C86803240 @default.
• W1975377584 hasConceptScore W1975377584C104317684 @default.
• W1975377584 hasConceptScore W1975377584C150903083 @default.
• W1975377584 hasConceptScore W1975377584C153911025 @default.
• W1975377584 hasConceptScore W1975377584C181199279 @default.
• W1975377584 hasConceptScore W1975377584C185592680 @default.
• W1975377584 hasConceptScore W1975377584C203014093 @default.
• W1975377584 hasConceptScore W1975377584C207001950 @default.
• W1975377584 hasConceptScore W1975377584C2780269544 @default.
• W1975377584 hasConceptScore W1975377584C2780340462 @default.
• W1975377584 hasConceptScore W1975377584C46111723 @default.
• W1975377584 hasConceptScore W1975377584C50817676 @default.

• next