FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1975381455> ?p ?o ?g. }

• W1975381455 endingPage "115" @default.
• W1975381455 startingPage "104" @default.
• W1975381455 abstract "Mechanical stimulation during cartilage tissue-engineering enhances extracellular matrix (ECM) synthesis and thereby improves the mechanical properties of tissue engineered (TE) cartilage. Generally, these mechanical stimuli are of a fixed magnitude. However, as a result of ECM synthesis and spatial variations thereof at both the macroscopic and microscopic scales, the internal mechanical conditions in the constructs change with time. Consequently, the physical signals in the environment of the cells will vary spatially and temporally, even though macroscopically the same loading is applied to the construct. The purpose of the present study was to numerically quantify such effects and thereby reveal the importance of adjusting loading regimes during cartilage tissue-engineering. A validated nonlinear fiber-reinforced poroviscoelastic swelling cartilage model that can accommodate for effects of collagen reinforcement and swelling by proteoglycans was used. At the microscopic scale, ECM was gradually varied from localized in the pericellular area, toward equally distributed throughout the surrounding interterritorial matrix. At the macroscopic tissue scale, ECM was gradually varied from predominantly localized in the periphery of the TE construct toward homogeneously distributed. Both concentration of ECM in the pericellular area and concentration of ECM in the periphery of a construct alter the physical signals up to an order of magnitude compared to those at the onset of the culture. Of particular interest, is the effect of elevated osmotic swelling pressure in the pericellular area, which shields not only the cells from receiving external mechanical compression, but also directly induces tension on the cells. Based on the present computational simulations, it is therefore, proposed that cartilage TE studies should consider ECM distribution as an important factor when developing loading protocols for cartilage culturing process. For instance, the level of mechanical compression should gradually increase to sufficiently deform chondrocytes over time, in case there is matrix accumulation in the pericellular area." @default.
• W1975381455 created "2016-06-24" @default.
• W1975381455 creator A5038035984 @default.
• W1975381455 creator A5066752472 @default.
• W1975381455 creator A5068407781 @default.
• W1975381455 creator A5085927001 @default.
• W1975381455 date "2014-02-01" @default.
• W1975381455 modified "2023-10-16" @default.
• W1975381455 title "The Effects of Matrix Inhomogeneities on the Cellular Mechanical Environment in Tissue-Engineered Cartilage: AnIn SilicoInvestigation" @default.
• W1975381455 cites W1964352781 @default.
• W1975381455 cites W1965415256 @default.
• W1975381455 cites W1966066347 @default.
• W1975381455 cites W1967618429 @default.
• W1975381455 cites W1969622566 @default.
• W1975381455 cites W1972523055 @default.
• W1975381455 cites W1980440152 @default.
• W1975381455 cites W1989535220 @default.
• W1975381455 cites W1989693137 @default.
• W1975381455 cites W1994233268 @default.
• W1975381455 cites W1997614695 @default.
• W1975381455 cites W2001407649 @default.
• W1975381455 cites W2002100798 @default.
• W1975381455 cites W2007029906 @default.
• W1975381455 cites W2007469598 @default.
• W1975381455 cites W2008178698 @default.
• W1975381455 cites W2009350275 @default.
• W1975381455 cites W2012044194 @default.
• W1975381455 cites W2018674961 @default.
• W1975381455 cites W2020342708 @default.
• W1975381455 cites W2020787517 @default.
• W1975381455 cites W2024347619 @default.
• W1975381455 cites W2026220322 @default.
• W1975381455 cites W2030001335 @default.
• W1975381455 cites W2033857223 @default.
• W1975381455 cites W2036685691 @default.
• W1975381455 cites W2037374077 @default.
• W1975381455 cites W2041831926 @default.
• W1975381455 cites W2043696490 @default.
• W1975381455 cites W2044553496 @default.
• W1975381455 cites W2045660556 @default.
• W1975381455 cites W2051016440 @default.
• W1975381455 cites W2051733665 @default.
• W1975381455 cites W2059224163 @default.
• W1975381455 cites W2063125290 @default.
• W1975381455 cites W2069925193 @default.
• W1975381455 cites W2071583928 @default.
• W1975381455 cites W2072589827 @default.
• W1975381455 cites W2079082206 @default.
• W1975381455 cites W2084610846 @default.
• W1975381455 cites W2085330804 @default.
• W1975381455 cites W2085947046 @default.
• W1975381455 cites W2087644457 @default.
• W1975381455 cites W2088715030 @default.
• W1975381455 cites W2090987680 @default.
• W1975381455 cites W2092301768 @default.
• W1975381455 cites W2103984479 @default.
• W1975381455 cites W2111781374 @default.
• W1975381455 cites W2118027609 @default.
• W1975381455 cites W2121992912 @default.
• W1975381455 cites W2123123614 @default.
• W1975381455 cites W2123790767 @default.
• W1975381455 cites W2128433838 @default.
• W1975381455 cites W2128995541 @default.
• W1975381455 cites W2131456542 @default.
• W1975381455 cites W2132672302 @default.
• W1975381455 cites W2139107515 @default.
• W1975381455 cites W2146282939 @default.
• W1975381455 cites W2147526125 @default.
• W1975381455 cites W2149100719 @default.
• W1975381455 cites W2152637989 @default.
• W1975381455 cites W2165569726 @default.
• W1975381455 cites W2166389186 @default.
• W1975381455 cites W2168961681 @default.
• W1975381455 cites W2186680027 @default.
• W1975381455 cites W2320153109 @default.
• W1975381455 cites W247719737 @default.
• W1975381455 doi "https://doi.org/10.1089/ten.tec.2012.0698" @default.
• W1975381455 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23679046" @default.
• W1975381455 hasPublicationYear "2014" @default.
• W1975381455 type Work @default.
• W1975381455 sameAs 1975381455 @default.
• W1975381455 citedByCount "5" @default.
• W1975381455 countsByYear W19753814552014 @default.
• W1975381455 countsByYear W19753814552015 @default.
• W1975381455 countsByYear W19753814552016 @default.
• W1975381455 countsByYear W19753814552017 @default.
• W1975381455 crossrefType "journal-article" @default.
• W1975381455 hasAuthorship W1975381455A5038035984 @default.
• W1975381455 hasAuthorship W1975381455A5066752472 @default.
• W1975381455 hasAuthorship W1975381455A5068407781 @default.
• W1975381455 hasAuthorship W1975381455A5085927001 @default.
• W1975381455 hasConcept C105702510 @default.
• W1975381455 hasConcept C106487976 @default.
• W1975381455 hasConcept C12554922 @default.
• W1975381455 hasConcept C136229726 @default.
• W1975381455 hasConcept C159985019 @default.
• W1975381455 hasConcept C185592680 @default.
• W1975381455 hasConcept C189165786 @default.

• next