FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1975389666> ?p ?o ?g. }

• W1975389666 endingPage "214" @default.
• W1975389666 startingPage "207" @default.
• W1975389666 abstract "Comprehensive knowledge of the brain’s wiring diagram is fundamental for understanding how the nervous system processes information at both local and global scales. However, with the singular exception of the C. elegans microscale connectome, there are no complete connectivity data sets in other species. Here we report a brain-wide, cellular-level, mesoscale connectome for the mouse. The Allen Mouse Brain Connectivity Atlas uses enhanced green fluorescent protein (EGFP)-expressing adeno-associated viral vectors to trace axonal projections from defined regions and cell types, and high-throughput serial two-photon tomography to image the EGFP-labelled axons throughout the brain. This systematic and standardized approach allows spatial registration of individual experiments into a common three dimensional (3D) reference space, resulting in a whole-brain connectivity matrix. A computational model yields insights into connectional strength distribution, symmetry and other network properties. Virtual tractography illustrates 3D topography among interconnected regions. Cortico-thalamic pathway analysis demonstrates segregation and integration of parallel pathways. The Allen Mouse Brain Connectivity Atlas is a freely available, foundational resource for structural and functional investigations into the neural circuits that support behavioural and cognitive processes in health and disease. In mouse, an axonal connectivity map showing the wiring patterns across the entire brain has been created using an EGFP-expressing adeno-associated virus tracing technique, providing the first such whole-brain map for a vertebrate species. With President Barack Obama's BRAIN (Brain Research through Advancing Innovative Neurotechnologies) initiative now entering year two, this issue of Nature presents two landmark papers that mobilize 'big science' resources to the cause. Hongkui Zeng and colleagues present the first brain-wide, mesoscale connectome for a mammalian species — the laboratory mouse — based on cell-type-specific tracing of axonal projections. The wiring diagram of a complete nervous system has long been available for a small roundworm, but neuronal connectivity data for larger animals has been patchy until now. The new three-dimensional Allen Mouse Brain Connectivity Atlas is a whole-brain connectivity matrix that will provide insights into how brain regions communicate. Much of the data generated in this project will be of relevance to investigations of neural networks in humans and should help to further our understanding of human brain connectivity and its involvement in brain disorders. In a separate report Ed Lein and colleagues present a transcriptional atlas of the mid-gestational human brain at high spatial resolution, based on laser microdissection and DNA microarray technology. The structure and function of the human brain is largely determined by prenatal transcriptional processes that initiate gene expression, but our understanding of the developing brain has been limited. The new data set reveals transcriptional signatures for developmental processes associated with the massive expansion of neocortex during human evolution, and suggests new cortical germinal zones or postmitotic neurons as sites of dynamic expression for many genes associated with neurological or psychiatric disorders." @default.
• W1975389666 created "2016-06-24" @default.
• W1975389666 creator A5001706587 @default.
• W1975389666 creator A5010189175 @default.
• W1975389666 creator A5011591095 @default.
• W1975389666 creator A5011660493 @default.
• W1975389666 creator A5013522573 @default.
• W1975389666 creator A5016353246 @default.
• W1975389666 creator A5017219333 @default.
• W1975389666 creator A5018764924 @default.
• W1975389666 creator A5020449033 @default.
• W1975389666 creator A5024647642 @default.
• W1975389666 creator A5029083925 @default.
• W1975389666 creator A5030576276 @default.
• W1975389666 creator A5036224886 @default.
• W1975389666 creator A5038335426 @default.
• W1975389666 creator A5043877753 @default.
• W1975389666 creator A5044283681 @default.
• W1975389666 creator A5045361774 @default.
• W1975389666 creator A5046198290 @default.
• W1975389666 creator A5051190137 @default.
• W1975389666 creator A5051467845 @default.
• W1975389666 creator A5058724676 @default.
• W1975389666 creator A5061445053 @default.
• W1975389666 creator A5066235424 @default.
• W1975389666 creator A5067041563 @default.
• W1975389666 creator A5069851488 @default.
• W1975389666 creator A5071903249 @default.
• W1975389666 creator A5072126704 @default.
• W1975389666 creator A5073792692 @default.
• W1975389666 creator A5074982934 @default.
• W1975389666 creator A5077319972 @default.
• W1975389666 creator A5079851326 @default.
• W1975389666 creator A5084822308 @default.
• W1975389666 creator A5087078320 @default.
• W1975389666 creator A5090586758 @default.
• W1975389666 date "2014-04-01" @default.
• W1975389666 modified "2023-10-10" @default.
• W1975389666 title "A mesoscale connectome of the mouse brain" @default.
• W1975389666 cites W1508489241 @default.
• W1975389666 cites W1898809910 @default.
• W1975389666 cites W191642185 @default.
• W1975389666 cites W1954127107 @default.
• W1975389666 cites W1963513644 @default.
• W1975389666 cites W1965453247 @default.
• W1975389666 cites W1967463795 @default.
• W1975389666 cites W1970022438 @default.
• W1975389666 cites W1974458913 @default.
• W1975389666 cites W1975290569 @default.
• W1975389666 cites W1977274382 @default.
• W1975389666 cites W1977412641 @default.
• W1975389666 cites W1977691361 @default.
• W1975389666 cites W1978906168 @default.
• W1975389666 cites W1980944755 @default.
• W1975389666 cites W1982454095 @default.
• W1975389666 cites W1987688885 @default.
• W1975389666 cites W1987971576 @default.
• W1975389666 cites W1989087672 @default.
• W1975389666 cites W1989456554 @default.
• W1975389666 cites W1989469817 @default.
• W1975389666 cites W1989621138 @default.
• W1975389666 cites W1990698682 @default.
• W1975389666 cites W1993621549 @default.
• W1975389666 cites W1995675400 @default.
• W1975389666 cites W1998704822 @default.
• W1975389666 cites W1998722012 @default.
• W1975389666 cites W1999185738 @default.
• W1975389666 cites W1999653836 @default.
• W1975389666 cites W1999896174 @default.
• W1975389666 cites W2004448205 @default.
• W1975389666 cites W2006335093 @default.
• W1975389666 cites W2007541448 @default.
• W1975389666 cites W2007939990 @default.
• W1975389666 cites W2008620264 @default.
• W1975389666 cites W2008971998 @default.
• W1975389666 cites W2011540890 @default.
• W1975389666 cites W2012068152 @default.
• W1975389666 cites W2012483271 @default.
• W1975389666 cites W2013679333 @default.
• W1975389666 cites W2015797663 @default.
• W1975389666 cites W2022235653 @default.
• W1975389666 cites W2022387796 @default.
• W1975389666 cites W2024729467 @default.
• W1975389666 cites W2034408566 @default.
• W1975389666 cites W2034953594 @default.
• W1975389666 cites W2035395691 @default.
• W1975389666 cites W2036214063 @default.
• W1975389666 cites W2036883654 @default.
• W1975389666 cites W2040234218 @default.
• W1975389666 cites W2040847356 @default.
• W1975389666 cites W2042041295 @default.
• W1975389666 cites W2043606478 @default.
• W1975389666 cites W2049031669 @default.
• W1975389666 cites W2054508155 @default.
• W1975389666 cites W2054870083 @default.
• W1975389666 cites W2055091793 @default.
• W1975389666 cites W2056860237 @default.
• W1975389666 cites W2058483899 @default.

• next