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- W1975390891 abstract "The objective of the present study was to measure electrographic changes occurring in the hypothalamus of the rat with morphine. Recordings were obtained from 8 rats after saline, 8 mg/kg or 16 mg/kg intraperitoneal injections of morphine. The data were subjected to spectral analysis, and statistical ocmparisons were made of changes in intensity and per cent of total intensity occurring in each of the standard frequency bands under the various conditions. The effects varied for different electrode sites, but a general trend toward increases in both intensity and per cent of theta and alpha activity and decreases in delta activity with the drug was observed. Frequent occurrence of spike-dome activity was also noted. The possible relationship between spectral analysis profiles, spike-dome discharges and unit activity were discussed, and consideration was given to the possibility that a shift toward high amplitude, synchronous electrical activity in the hypothalamus is a correlate of the positive reinforcing effects of morphine." @default.
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- W1975390891 date "1976-02-01" @default.
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- W1975390891 title "The effect of morphine on the EEG of the hypothalamus in the rat" @default.
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- W1975390891 doi "https://doi.org/10.1016/0031-9384(76)90301-2" @default.
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