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• W1975391725 endingPage "74" @default.
• W1975391725 startingPage "53" @default.
• W1975391725 abstract "The S-100 protein is specific for the nervous system and, being present in all vertebrates, shows a high degree of stability of structure during evolution. In adult animals it is primarily localized to glial elements, although there is some evidence that a small proportion may be present in neuronal nuclei or their plasma membranes. During development it is synthesized rapidly at a relatively late period of differentiation of the nervous system. In glioma cell cultures there is a control mechanism that seems to involve some kind of signal at the external surface of the plasma membrane, possibly specific cell-cell contact, to stimulate S-100 synthesis. All of these biological properties of S-100 suggest that it is connected with some specific essential function that is common to the nervous system of all vertebrates. Several chemical properties of S-100 provide clues to this function. It is an unusually acidic and soluble protein and, in the absence of Ca2+, has no detectable hydrophobic regions accessible to solvent. It is capable of specifically binding Ca2+, a process that causes S-100 to undergo a conformational change that exposes a hydrophobic region to the solvent and stimulates binding of S-100 to membranes. The conformational change and the membrane-binding properties are reversible when Ca2+ is removed and are antagonized by monovalent cations such as K+ and Na+. These chemical properties suggest that S-100 may, as part of its function in the nervous system, be bound to some hydrophobic site, possibly a membrane, and that the extent of this binding is regulated by concentrations of Ca2+, K+ and Na+. If this is true, then it is important, as the next step in working out its function, to discover the exact site where S-100 binds in the nervous system." @default.
• W1975391725 created "2016-06-24" @default.
• W1975391725 creator A5070798283 @default.
• W1975391725 date "1982-11-01" @default.
• W1975391725 modified "2023-09-29" @default.
• W1975391725 title "Chemistry and Biology of the S-100 Protein" @default.
• W1975391725 cites W124780425 @default.
• W1975391725 cites W1495498649 @default.
• W1975391725 cites W1525326122 @default.
• W1975391725 cites W1557412554 @default.
• W1975391725 cites W1560853121 @default.
• W1975391725 cites W1571879383 @default.
• W1975391725 cites W1581874507 @default.
• W1975391725 cites W1585990439 @default.
• W1975391725 cites W1590744179 @default.
• W1975391725 cites W171508795 @default.
• W1975391725 cites W1964567086 @default.
• W1975391725 cites W1968982548 @default.
• W1975391725 cites W1969364427 @default.
• W1975391725 cites W1971436363 @default.
• W1975391725 cites W1974203641 @default.
• W1975391725 cites W1976416760 @default.
• W1975391725 cites W1976476521 @default.
• W1975391725 cites W1977111358 @default.
• W1975391725 cites W1977790868 @default.
• W1975391725 cites W1978163143 @default.
• W1975391725 cites W1983557791 @default.
• W1975391725 cites W1985498886 @default.
• W1975391725 cites W1985739759 @default.
• W1975391725 cites W1986807148 @default.
• W1975391725 cites W1986889051 @default.
• W1975391725 cites W1987759727 @default.
• W1975391725 cites W1988896402 @default.
• W1975391725 cites W1989416232 @default.
• W1975391725 cites W1990918868 @default.
• W1975391725 cites W1990999345 @default.
• W1975391725 cites W1991380950 @default.
• W1975391725 cites W1991393062 @default.
• W1975391725 cites W1992229778 @default.
• W1975391725 cites W1992846638 @default.
• W1975391725 cites W1995905279 @default.
• W1975391725 cites W1996006536 @default.
• W1975391725 cites W1998484716 @default.
• W1975391725 cites W2000101157 @default.
• W1975391725 cites W2000916808 @default.
• W1975391725 cites W2001106514 @default.
• W1975391725 cites W2005076300 @default.
• W1975391725 cites W2005308801 @default.
• W1975391725 cites W2005623297 @default.
• W1975391725 cites W2011518564 @default.
• W1975391725 cites W2015576933 @default.
• W1975391725 cites W2016859569 @default.
• W1975391725 cites W2020038167 @default.
• W1975391725 cites W2020773936 @default.
• W1975391725 cites W2020832062 @default.
• W1975391725 cites W2022195177 @default.
• W1975391725 cites W2022321757 @default.
• W1975391725 cites W2022493188 @default.
• W1975391725 cites W2023845339 @default.
• W1975391725 cites W2024393903 @default.
• W1975391725 cites W2026796654 @default.
• W1975391725 cites W2026975369 @default.
• W1975391725 cites W2029745470 @default.
• W1975391725 cites W2031305077 @default.
• W1975391725 cites W2031460862 @default.
• W1975391725 cites W2032316952 @default.
• W1975391725 cites W2035766119 @default.
• W1975391725 cites W2036801458 @default.
• W1975391725 cites W2037157916 @default.
• W1975391725 cites W2038384073 @default.
• W1975391725 cites W2039679369 @default.
• W1975391725 cites W2041107699 @default.
• W1975391725 cites W2042049165 @default.
• W1975391725 cites W2044971956 @default.
• W1975391725 cites W2046946121 @default.
• W1975391725 cites W2047837811 @default.
• W1975391725 cites W2048407300 @default.
• W1975391725 cites W2051870933 @default.
• W1975391725 cites W2055381700 @default.
• W1975391725 cites W2057243020 @default.
• W1975391725 cites W2058539880 @default.
• W1975391725 cites W2059251216 @default.
• W1975391725 cites W2063456791 @default.
• W1975391725 cites W2065746768 @default.
• W1975391725 cites W2067722122 @default.
• W1975391725 cites W2068503925 @default.
• W1975391725 cites W2069788369 @default.
• W1975391725 cites W2071148795 @default.
• W1975391725 cites W2074057302 @default.
• W1975391725 cites W2076267708 @default.
• W1975391725 cites W2080274608 @default.
• W1975391725 cites W2088079434 @default.
• W1975391725 cites W2088745469 @default.
• W1975391725 cites W2089837582 @default.
• W1975391725 cites W2091826796 @default.
• W1975391725 cites W2092644952 @default.
• W1975391725 cites W2092817601 @default.
• W1975391725 cites W2093141414 @default.

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