FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1975398457> ?p ?o ?g. }

• W1975398457 endingPage "1447" @default.
• W1975398457 startingPage "1438" @default.
• W1975398457 abstract "Contraction is a critical phase of immunity whereby the vast majority of effector T cells die by apoptosis, sparing a population of long-lived memory cells. Where, when, and why contraction occurs has been difficult to address directly due in large part to the rapid clearance of apoptotic T cells in vivo. To circumvent this issue, we introduced a genetically encoded reporter for caspase-3 activity into naive T cells to identify cells entering the contraction phase. Using two-photon imaging, we found that caspase-3 activity in T cells was maximal at the peak of the response and was associated with loss of motility followed minutes later by cell death. We demonstrated that contraction is a widespread process occurring uniformly in all organs tested and targeting phenotypically diverse T cells. Importantly, we identified a critical window of time during which antigen encounters act to antagonize T cell apoptosis, supporting a causal link between antigen clearance and T cell contraction. Our results offer insight into a poorly explored phase of immunity and provide a versatile methodology to study apoptosis during the development or function of a variety of immune cells in vivo." @default.
• W1975398457 created "2016-06-24" @default.
• W1975398457 creator A5031971429 @default.
• W1975398457 creator A5035878821 @default.
• W1975398457 creator A5038619401 @default.
• W1975398457 creator A5039812479 @default.
• W1975398457 creator A5044439182 @default.
• W1975398457 creator A5078075662 @default.
• W1975398457 creator A5090496106 @default.
• W1975398457 date "2012-11-01" @default.
• W1975398457 modified "2023-09-30" @default.
• W1975398457 title "Dissecting T Cell Contraction In Vivo Using a Genetically Encoded Reporter of Apoptosis" @default.
• W1975398457 cites W1482928030 @default.
• W1975398457 cites W1491842889 @default.
• W1975398457 cites W1507800008 @default.
• W1975398457 cites W1509274319 @default.
• W1975398457 cites W1520290955 @default.
• W1975398457 cites W1593985009 @default.
• W1975398457 cites W1737540175 @default.
• W1975398457 cites W1760248554 @default.
• W1975398457 cites W1969003615 @default.
• W1975398457 cites W1969231504 @default.
• W1975398457 cites W1973390559 @default.
• W1975398457 cites W1982226677 @default.
• W1975398457 cites W1985294654 @default.
• W1975398457 cites W1986376227 @default.
• W1975398457 cites W2002541767 @default.
• W1975398457 cites W2007939817 @default.
• W1975398457 cites W2008757142 @default.
• W1975398457 cites W2017669223 @default.
• W1975398457 cites W2039236540 @default.
• W1975398457 cites W2042519375 @default.
• W1975398457 cites W2046491426 @default.
• W1975398457 cites W2051972593 @default.
• W1975398457 cites W2052573176 @default.
• W1975398457 cites W2059431619 @default.
• W1975398457 cites W2069749184 @default.
• W1975398457 cites W2070190623 @default.
• W1975398457 cites W2070552972 @default.
• W1975398457 cites W2087501355 @default.
• W1975398457 cites W2088801927 @default.
• W1975398457 cites W2089372310 @default.
• W1975398457 cites W2089724011 @default.
• W1975398457 cites W2091218020 @default.
• W1975398457 cites W2093578282 @default.
• W1975398457 cites W2094646968 @default.
• W1975398457 cites W2101302340 @default.
• W1975398457 cites W2102859042 @default.
• W1975398457 cites W2102950218 @default.
• W1975398457 cites W2106758295 @default.
• W1975398457 cites W2108520490 @default.
• W1975398457 cites W2123186469 @default.
• W1975398457 cites W2135360970 @default.
• W1975398457 cites W2141205048 @default.
• W1975398457 cites W2143769665 @default.
• W1975398457 cites W2145341441 @default.
• W1975398457 cites W2148817537 @default.
• W1975398457 cites W2156482394 @default.
• W1975398457 cites W2170904230 @default.
• W1975398457 doi "https://doi.org/10.1016/j.celrep.2012.10.015" @default.
• W1975398457 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23159042" @default.
• W1975398457 hasPublicationYear "2012" @default.
• W1975398457 type Work @default.
• W1975398457 sameAs 1975398457 @default.
• W1975398457 citedByCount "62" @default.
• W1975398457 countsByYear W19753984572013 @default.
• W1975398457 countsByYear W19753984572014 @default.
• W1975398457 countsByYear W19753984572015 @default.
• W1975398457 countsByYear W19753984572016 @default.
• W1975398457 countsByYear W19753984572017 @default.
• W1975398457 countsByYear W19753984572018 @default.
• W1975398457 countsByYear W19753984572019 @default.
• W1975398457 countsByYear W19753984572020 @default.
• W1975398457 countsByYear W19753984572021 @default.
• W1975398457 countsByYear W19753984572022 @default.
• W1975398457 countsByYear W19753984572023 @default.
• W1975398457 crossrefType "journal-article" @default.
• W1975398457 hasAuthorship W1975398457A5031971429 @default.
• W1975398457 hasAuthorship W1975398457A5035878821 @default.
• W1975398457 hasAuthorship W1975398457A5038619401 @default.
• W1975398457 hasAuthorship W1975398457A5039812479 @default.
• W1975398457 hasAuthorship W1975398457A5044439182 @default.
• W1975398457 hasAuthorship W1975398457A5078075662 @default.
• W1975398457 hasAuthorship W1975398457A5090496106 @default.
• W1975398457 hasBestOaLocation W19753984571 @default.
• W1975398457 hasConcept C134018914 @default.
• W1975398457 hasConcept C1491633281 @default.
• W1975398457 hasConcept C154317977 @default.
• W1975398457 hasConcept C163415756 @default.
• W1975398457 hasConcept C190283241 @default.
• W1975398457 hasConcept C202751555 @default.
• W1975398457 hasConcept C203014093 @default.
• W1975398457 hasConcept C207001950 @default.
• W1975398457 hasConcept C2776090121 @default.
• W1975398457 hasConcept C2908647359 @default.
• W1975398457 hasConcept C51785407 @default.
• W1975398457 hasConcept C54355233 @default.
• W1975398457 hasConcept C71924100 @default.

• next