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- W1975418557 abstract "Aims: To investigate the clinicopathological characteristics of 20 primary gastric T‐cell lymphoma (GTCL) cases without human T‐lymphotropic virus type I infection in Japan, a non‐endemic area for coeliac disease. Methods and results: Fifteen cases had no history of persistent diarrhoea or severe hypoproteinaemia. Histologically, 13 cases (65%) consisted of large cell lymphoma and seven (35%) were of medium‐sized cells. Intraepithelial lymphoma cell invasion was found in three cases (15%). Two of 10 surgical cases (20%) showed intramucosal tumour cell spreading with enteropathy‐like features. Helicobacter pylori CagA gene was detected in three of 10 cases (30%). The lymphoma cells of all 20 cases were positive for CD3 and/or TCRβF1 and negative for CD56. CD4− and CD8− lymphoma was found in 11 cases (55%), CD4+ lymphoma in seven (35%) and CD8+ lymphoma in two (10%). CD30+, CD5+ and CD25+ lymphomas were detected in nine (45%), 10 (50%) and 11 (55%) cases, respectively. Five‐year survival of the 16 available cases was 54%. Early clinical stage and medium‐sized cell lymphoma were significantly ( P < 0.05) better prognostic factors. Conclusions: Patients with GTCL exhibit distinct clinicopathological findings and prognoses from those with enteropathy‐associated T‐cell lymphomas. GTCL may be mainly derived from lamina propria and parafollicular T cells." @default.
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- W1975418557 date "2009-11-26" @default.
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- W1975418557 title "Clinicopathological characteristics of primary gastric T-cell lymphoma" @default.
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- W1975418557 doi "https://doi.org/10.1111/j.1365-2559.2009.03430.x" @default.
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