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- W1975431323 startingPage "8206" @default.
- W1975431323 abstract "Using recombinant DNA techniques, we reconstructed a genealogical tree (Sablitzky, F., Wildner, G. & Rajewsky, K. (1985) EMBO J. 4, 345-350) that connects three clonally related B cells producing somatically mutated antibodies to a progenitor cell expressing a germ line-encoded antibody. The somatic mutants had been isolated from an in vivo immune response. The germ line-encoded progenitor antibody bound the antigen with high affinity. Intraclonal affinity maturation occurred stepwise over a 15-fold range." @default.
- W1975431323 created "2016-06-24" @default.
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- W1975431323 creator A5074085102 @default.
- W1975431323 date "1988-11-01" @default.
- W1975431323 modified "2023-10-16" @default.
- W1975431323 title "Stepwise intraclonal maturation of antibody affinity through somatic hypermutation." @default.
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- W1975431323 doi "https://doi.org/10.1073/pnas.85.21.8206" @default.
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