FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1975435105> ?p ?o ?g. }

• W1975435105 abstract "Thymocyte maturation in the thymus is controlled by stromal and humoral components. Among the humoral regulators locally produced glucocorticoids (GCs) seem to have a key role in the positive selection of thymocytes. Our previous studies have shown that the administration of GCs or the stimulation through the CD3 complex can induce apoptosis of double positive (DP) cells, but the combined presence of these stimuli induces positive selection. In this work our aim was to investigate the effects of antigen exposure and synthetic GC hormone (dexamethasone, DX) administration on the selection processes of DP cells in TcR transgenic mice. In our model, AND-pigeon cytochrome c (PCC)-specific I-E(k) (MHC-II) restricted Vbeta3, Valpha11 TcR expressing transgenic mice were treated with PCC, with high or low dose DX, or with PCC and DX together, followed by the analysis of total thymocyte numbers, thymocyte composition, with regard to their CD69, Vbeta3 and Annexin V expression. The administration of PCC and/or DX for 2 days resulted in a decreased DP cell number and a significantly increased CD4 SP cell ratio. However, in both cases the total thymocyte numbers decreased. CD69 expression increased on both DP and CD4 SP cells after PCC and/or DX treatments. We found that after DX or combined treatment, the percentage of Annexin V positive cells increased. The ratio of Vbeta3 TcR bearing DP thymocytes showed no change after DX or PCC administrations alone, but it decreased significantly after combined treatment. MHC-II bound PCC peptides in the presence of GCs enhanced the maturation of Vbeta3+ DP cells into CD4 SP stage, therefore, the Vbeta3- cells remained mostly in the DP immature stage. These data indicate that both antigen and low dose GC alone are capable of inducing positive selection of DP cells, but together they gave a stronger effect in promoting positive selection. From these we conclude that GCs influence the maturation and selection processes of thymocytes." @default.
• W1975435105 created "2016-06-24" @default.
• W1975435105 creator A5009942315 @default.
• W1975435105 creator A5015026965 @default.
• W1975435105 creator A5039609316 @default.
• W1975435105 creator A5053948161 @default.
• W1975435105 creator A5063858320 @default.
• W1975435105 date "2003-12-01" @default.
• W1975435105 modified "2023-10-17" @default.
• W1975435105 title "Antigen and glucocorticoid hormone (GC) induce positive selection of DP thymocytes in a TcR transgenic mouse model" @default.
• W1975435105 cites W1533917771 @default.
• W1975435105 cites W1534409678 @default.
• W1975435105 cites W1593628997 @default.
• W1975435105 cites W1605079513 @default.
• W1975435105 cites W1825379854 @default.
• W1975435105 cites W1968273066 @default.
• W1975435105 cites W1994617925 @default.
• W1975435105 cites W1999157348 @default.
• W1975435105 cites W2013930926 @default.
• W1975435105 cites W2019547342 @default.
• W1975435105 cites W2038714288 @default.
• W1975435105 cites W2044677659 @default.
• W1975435105 cites W2049722388 @default.
• W1975435105 cites W2060942281 @default.
• W1975435105 cites W2070983924 @default.
• W1975435105 cites W2078532650 @default.
• W1975435105 cites W2086572297 @default.
• W1975435105 cites W2096992142 @default.
• W1975435105 cites W2114569569 @default.
• W1975435105 cites W2115727942 @default.
• W1975435105 cites W2131055200 @default.
• W1975435105 cites W2148562724 @default.
• W1975435105 cites W2149553530 @default.
• W1975435105 cites W2149796686 @default.
• W1975435105 cites W2154770478 @default.
• W1975435105 cites W2160419609 @default.
• W1975435105 cites W2166291746 @default.
• W1975435105 cites W2169010845 @default.
• W1975435105 cites W2412708258 @default.
• W1975435105 cites W40843633 @default.
• W1975435105 doi "https://doi.org/10.1016/j.imlet.2003.08.001" @default.
• W1975435105 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14687711" @default.
• W1975435105 hasPublicationYear "2003" @default.
• W1975435105 type Work @default.
• W1975435105 sameAs 1975435105 @default.
• W1975435105 citedByCount "8" @default.
• W1975435105 countsByYear W19754351052013 @default.
• W1975435105 countsByYear W19754351052014 @default.
• W1975435105 countsByYear W19754351052018 @default.
• W1975435105 crossrefType "journal-article" @default.
• W1975435105 hasAuthorship W1975435105A5009942315 @default.
• W1975435105 hasAuthorship W1975435105A5015026965 @default.
• W1975435105 hasAuthorship W1975435105A5039609316 @default.
• W1975435105 hasAuthorship W1975435105A5053948161 @default.
• W1975435105 hasAuthorship W1975435105A5063858320 @default.
• W1975435105 hasConcept C114684123 @default.
• W1975435105 hasConcept C126322002 @default.
• W1975435105 hasConcept C134018914 @default.
• W1975435105 hasConcept C147483822 @default.
• W1975435105 hasConcept C153911025 @default.
• W1975435105 hasConcept C167672396 @default.
• W1975435105 hasConcept C185592680 @default.
• W1975435105 hasConcept C19317047 @default.
• W1975435105 hasConcept C203014093 @default.
• W1975435105 hasConcept C2776090121 @default.
• W1975435105 hasConcept C2778954852 @default.
• W1975435105 hasConcept C2780841215 @default.
• W1975435105 hasConcept C553184892 @default.
• W1975435105 hasConcept C71924100 @default.
• W1975435105 hasConcept C86803240 @default.
• W1975435105 hasConcept C88634738 @default.
• W1975435105 hasConcept C8891405 @default.
• W1975435105 hasConceptScore W1975435105C114684123 @default.
• W1975435105 hasConceptScore W1975435105C126322002 @default.
• W1975435105 hasConceptScore W1975435105C134018914 @default.
• W1975435105 hasConceptScore W1975435105C147483822 @default.
• W1975435105 hasConceptScore W1975435105C153911025 @default.
• W1975435105 hasConceptScore W1975435105C167672396 @default.
• W1975435105 hasConceptScore W1975435105C185592680 @default.
• W1975435105 hasConceptScore W1975435105C19317047 @default.
• W1975435105 hasConceptScore W1975435105C203014093 @default.
• W1975435105 hasConceptScore W1975435105C2776090121 @default.
• W1975435105 hasConceptScore W1975435105C2778954852 @default.
• W1975435105 hasConceptScore W1975435105C2780841215 @default.
• W1975435105 hasConceptScore W1975435105C553184892 @default.
• W1975435105 hasConceptScore W1975435105C71924100 @default.
• W1975435105 hasConceptScore W1975435105C86803240 @default.
• W1975435105 hasConceptScore W1975435105C88634738 @default.
• W1975435105 hasConceptScore W1975435105C8891405 @default.
• W1975435105 hasLocation W19754351051 @default.
• W1975435105 hasLocation W19754351052 @default.
• W1975435105 hasOpenAccess W1975435105 @default.
• W1975435105 hasPrimaryLocation W19754351051 @default.
• W1975435105 hasRelatedWork W1552483141 @default.
• W1975435105 hasRelatedWork W1958617503 @default.
• W1975435105 hasRelatedWork W2029762573 @default.
• W1975435105 hasRelatedWork W2049425355 @default.
• W1975435105 hasRelatedWork W2067190664 @default.
• W1975435105 hasRelatedWork W2074828277 @default.
• W1975435105 hasRelatedWork W2093020311 @default.

• next