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- W1975441771 abstract "The in vivo administration of a fraction obtained by partial purification of radix ginseng extract stimulated the incorporation rate of labeled precursors into nuclear RNA, and a maximum increase was shown at 4 hr after a single dose intraperitoneal injection and the rate returned almost to the control level 24 hr after treatment in a rat. However, the RNA content of nuclei isolated from each interval after treatment is the same in the RNA to DNA ratio as in the control animals. The sedimentation profile by sucrose density gradient of rapidly labled nuclear RNA isolated from the liver of a rat treated with fraction 4 showed a stimulation in the 23s to 7s region which has a peak at 1Os region. Rate of the incorporation of labeled precursors into the interphase RNA rather than the nuclear sap RNA was stimulated significantly by fraction 3 and the base composition of this 32P pulse-labeled RNA showed an intermediate value between the ribosamal and DNA-like RNA. The effect of ginseng extract (fraction 3) on the nuclear DNA synthesis was not observed in the present assay by the incorporation of 3H-thymidine in rat liver." @default.
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- W1975441771 date "1971-01-01" @default.
- W1975441771 modified "2023-09-27" @default.
- W1975441771 title "Synthesis and Characterization of Nuclear RNA induced by Radix Ginseng Extract in Rat Liver" @default.
- W1975441771 doi "https://doi.org/10.1248/cpb.19.1598" @default.
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