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- W1975445093 abstract "Ku, a heterodimer of 70 and 86 kDa subunits, plays a critical but poorly understood role in V(D)J recombination. Although Ku86-deficient mice are defective in coding and signal joint formation, rare recombination products have been detected by PCR. Here, we report nucleotide sequences of 99 junctions from Ku86-deficient mice. Over 90% of the coding joints, but not signal or hybrid joints, exhibit short sequence homologies, indicating that homology is required to join coding ends in the absence of Ku86. Our results suggest that Ku86 may normally have distinct functions in the formation of these different types of junctions. Furthermore, Ku86−/− joints are unexpectedly devoid of N-region diversity, suggesting a novel role for Ku in the addition of N nucleotides by terminal deoxynucleotidyl transferase." @default.
- W1975445093 created "2016-06-24" @default.
- W1975445093 creator A5011527055 @default.
- W1975445093 creator A5019090106 @default.
- W1975445093 creator A5085313543 @default.
- W1975445093 creator A5087693607 @default.
- W1975445093 date "1997-07-01" @default.
- W1975445093 modified "2023-10-18" @default.
- W1975445093 title "V(D)J Recombination in Ku86-Deficient Mice: Distinct Effects on Coding, Signal, and Hybrid Joint Formation" @default.
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- W1975445093 cites W1509547277 @default.
- W1975445093 cites W1543815058 @default.
- W1975445093 cites W1557970645 @default.
- W1975445093 cites W1580710981 @default.
- W1975445093 cites W1601999342 @default.
- W1975445093 cites W1637561808 @default.
- W1975445093 cites W169978917 @default.
- W1975445093 cites W1758411536 @default.
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- W1975445093 cites W1911716715 @default.
- W1975445093 cites W1924473599 @default.
- W1975445093 cites W1965163675 @default.
- W1975445093 cites W1966427800 @default.
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- W1975445093 cites W1987850577 @default.
- W1975445093 cites W1992177816 @default.
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- W1975445093 cites W2014800740 @default.
- W1975445093 cites W2019871838 @default.
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- W1975445093 cites W2037517612 @default.
- W1975445093 cites W2038794308 @default.
- W1975445093 cites W2039183914 @default.
- W1975445093 cites W2049123604 @default.
- W1975445093 cites W2050291003 @default.
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- W1975445093 cites W2075359803 @default.
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- W1975445093 doi "https://doi.org/10.1016/s1074-7613(00)80508-7" @default.
- W1975445093 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9252118" @default.
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