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• W1975454207 endingPage "1172" @default.
• W1975454207 startingPage "1158" @default.
• W1975454207 abstract "Antimicrobial peptide drugs are increasingly attractive therapeutic agents as their roles in physiopathological processes are being unraveled and because the development of recombinant DNA technology has made them economically affordable in large amounts and high purity. However, due to lack of specificity regarding the target cells, difficulty in attaining them, or reduced half-lives, most current administration methods require high doses. On the other hand, reduced specificity of toxic drugs demands low concentrations to minimize undesirable side-effects, thus incurring the risk of having sublethal amounts which favour the appearance of resistant microbial strains. In this scenario, targeted delivery can fulfill the objective of achieving the intake of total quantities sufficiently low to be innocuous for the patient but that locally are high enough to be lethal for the infectious agent. One of the major advances in recent years has been the size reduction of drug carriers that have dimensions in the nanometer scale and thus are much smaller than —and capable of being internalized by— many types of cells. Among the different types of potential antimicrobial peptide-encapsulating structures reviewed here are liposomes, dendritic polymers, solid core nanoparticles, carbon nanotubes, and DNA cages. These nanoparticulate systems can be functionalized with a plethora of biomolecules providing specificity of binding to particular cell types or locations; as examples of these targeting elements we will present antibodies, DNA aptamers, cellpenetrating peptides, and carbohydrates. Multifunctional Trojan horse-like nanovessels can be engineered by choosing the adequate peptide content, encapsulating structure, and targeting moiety for each particular application. Keywords: Antibodies, aptamers, dendrimers, liposomes, nanomedicine, nanoparticles, nanovectors, targeting, Antimicrobial peptide, nanovessels" @default.
• W1975454207 created "2016-06-24" @default.
• W1975454207 creator A5045894108 @default.
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• W1975454207 creator A5075686017 @default.
• W1975454207 creator A5080057231 @default.
• W1975454207 creator A5080251786 @default.
• W1975454207 date "2012-07-01" @default.
• W1975454207 modified "2023-10-07" @default.
• W1975454207 title "Nanotools for the Delivery of Antimicrobial Peptides" @default.
• W1975454207 cites W1238203966 @default.
• W1975454207 cites W126577839 @default.
• W1975454207 cites W1497392903 @default.
• W1975454207 cites W1500701637 @default.
• W1975454207 cites W1518421316 @default.
• W1975454207 cites W1521624395 @default.
• W1975454207 cites W1564714809 @default.
• W1975454207 cites W1564937578 @default.
• W1975454207 cites W1572533571 @default.
• W1975454207 cites W1597160917 @default.
• W1975454207 cites W1789571946 @default.
• W1975454207 cites W179144004 @default.
• W1975454207 cites W1909728874 @default.
• W1975454207 cites W1914973957 @default.
• W1975454207 cites W1964252630 @default.
• W1975454207 cites W1964546003 @default.
• W1975454207 cites W1964696475 @default.
• W1975454207 cites W1965740944 @default.
• W1975454207 cites W1966418826 @default.
• W1975454207 cites W1966649591 @default.
• W1975454207 cites W1971264588 @default.
• W1975454207 cites W1972203768 @default.
• W1975454207 cites W1972675143 @default.
• W1975454207 cites W1976153850 @default.
• W1975454207 cites W1978581079 @default.
• W1975454207 cites W1979715507 @default.
• W1975454207 cites W1980791683 @default.
• W1975454207 cites W1981051452 @default.
• W1975454207 cites W1986529651 @default.
• W1975454207 cites W1986689667 @default.
• W1975454207 cites W1987250403 @default.
• W1975454207 cites W1989441984 @default.
• W1975454207 cites W1992226382 @default.
• W1975454207 cites W1993413788 @default.
• W1975454207 cites W1995131719 @default.
• W1975454207 cites W1996134990 @default.
• W1975454207 cites W1996998905 @default.
• W1975454207 cites W1997246078 @default.
• W1975454207 cites W1997455769 @default.
• W1975454207 cites W1997787046 @default.
• W1975454207 cites W1998019039 @default.
• W1975454207 cites W1998801332 @default.
• W1975454207 cites W1999745450 @default.
• W1975454207 cites W2002547990 @default.
• W1975454207 cites W2002661845 @default.
• W1975454207 cites W2002684795 @default.
• W1975454207 cites W2002843708 @default.
• W1975454207 cites W2003083375 @default.
• W1975454207 cites W2003688859 @default.
• W1975454207 cites W2004048765 @default.
• W1975454207 cites W2004390233 @default.
• W1975454207 cites W2005293289 @default.
• W1975454207 cites W2006570914 @default.
• W1975454207 cites W2006682004 @default.
• W1975454207 cites W2007010301 @default.
• W1975454207 cites W2007939418 @default.
• W1975454207 cites W2008039399 @default.
• W1975454207 cites W2008380896 @default.
• W1975454207 cites W2008576706 @default.
• W1975454207 cites W2009363563 @default.
• W1975454207 cites W2009600663 @default.
• W1975454207 cites W2009607104 @default.
• W1975454207 cites W2012078259 @default.
• W1975454207 cites W2012867962 @default.
• W1975454207 cites W2013348493 @default.
• W1975454207 cites W2013870905 @default.
• W1975454207 cites W2013899184 @default.
• W1975454207 cites W2019204164 @default.
• W1975454207 cites W2023456252 @default.
• W1975454207 cites W2024899874 @default.
• W1975454207 cites W2024960319 @default.
• W1975454207 cites W2026237349 @default.
• W1975454207 cites W2026301125 @default.
• W1975454207 cites W2028469454 @default.
• W1975454207 cites W2028568185 @default.
• W1975454207 cites W2028869453 @default.
• W1975454207 cites W2030855909 @default.
• W1975454207 cites W2031780453 @default.
• W1975454207 cites W2032381925 @default.
• W1975454207 cites W2033852473 @default.
• W1975454207 cites W2034265285 @default.
• W1975454207 cites W2036944284 @default.
• W1975454207 cites W2037305018 @default.
• W1975454207 cites W2038156304 @default.
• W1975454207 cites W2039506150 @default.
• W1975454207 cites W2040246879 @default.
• W1975454207 cites W2040963730 @default.

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