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• W1975459091 abstract "Two groups of non-demented individuals, who differed on genetic risk for Alzheimer's disease (AD) based on their apolipoprotein E (APOE) genotype, were tested on a category fluency task. Twenty ɛ4 carriers and twenty ɛ4 non-carriers were tape recorded while saying animal names for ten minutes. Five measures were examined: total names generated; total clusters; mean cluster size; mean within-cluster retrieval time; and mean between-cluster retrieval time. Groups were matched on age and education and scored as normal on a battery of psychometric tests. The ɛ4 carriers generated significantly fewer names and clusters, and took significantly longer to access clusters, when compared to the ɛ4 non-carriers. No group differences were found for cluster size or within-cluster retrieval times. We previously reported [Rosen, V. M., Bergeson, J. L., Putnam, K., Harwell, A., Sunderland, T. (2002). Working memory and apolipoprotein E: What's the connection? Neuropsychologia 40, 2226–2233] that the ɛ4 carriers in the present study scored significantly lower than the ɛ4 non-carriers on a measure of working memory/attentional capacity [Operation Span Task, see Turner, M. L., Engle, R. W. (1989). Is working memory capacity task dependent? Journal of Memory and Language 28, 127–154]. In the present study, a significant negative relationship found between span performance and between-cluster retrieval times suggested that reduced attentional capacity may have negatively impacted semantic access for the ɛ4 carriers. Finally, we found significant relationships between a Trail Making Test [Reitan, R. M. (1992). Trail Making Test, manual for administration and scoring. Tucson, AZ: Reitan Neuropsychology Laboratory] “switch” measure (Form B–Form A) and three of the five fluency measures. The findings suggested that the ɛ4 carrier's reduced attentional capacity may have interfered with their covertly shifting attention among subcategories in the fluency task, resulting in fewer names and clusters generated and longer times to access clusters." @default.
• W1975459091 created "2016-06-24" @default.
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• W1975459091 date "2005-01-01" @default.
• W1975459091 modified "2023-10-06" @default.
• W1975459091 title "Apolipoprotein E and category fluency: evidence for reduced semantic access in healthy normal controls at risk for developing Alzheimer's disease" @default.
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• W1975459091 doi "https://doi.org/10.1016/j.neuropsychologia.2004.06.022" @default.
• W1975459091 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15716154" @default.
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