FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1975479312> ?p ?o ?g. }

• W1975479312 endingPage "1325" @default.
• W1975479312 startingPage "1325" @default.
• W1975479312 abstract "Total bilateral corneal limbal epithelial stem cell deficiency (LSCD) cannot be treated with the surgical transplantation of autologous limbus or cultured autologous limbal epithelium. Transplantation of allogenic limbal epithelium is possible but requires immunosuppressive treatments. Cultured autologous oral mucosal epithelial cell sheet (CAOMECS) is a transparent, resistant, viable, and rapidly bioadhesive cell sheet, cultured with the UpCell-Insert technology (CellSeed, Inc., Tokyo, Japan), which allows for grafting onto the patient's corneal stroma without suturing. It has therefore been proposed as an alternative treatment for LSCD.The objectives were to assess the safety and efficacy of CAOMECS, using a prospective Gehan's design. Safety was measured in terms of ocular adverse events during the study period, and efficacy was measured using a composite criterion based on epithelial defect, punctate epithelial keratopathy, conjunctival epithelium on the cornea, number of vascular pediculi, and vessel activity.CAOMECS was found to be safe and effective. In total, 26 eyes of 25 patients received a graft. Two patients experienced serious adverse events classified as not product related. Twenty-five patients were included in the efficacy analysis, as one patient was lost to follow-up. The treatment was found to be effective in 16 of 25 patients at 360 days after grafting. Of the 23 patients who completed follow-up at 360 days, 22 had no ulcers, and 19 showed a decrease in the severity of the punctate epithelial keratopathy.CAOMECS is a well-tolerated and safe tissue-engineered product. These results suggest its efficacy for reconstructing the ocular surface in patients with total bilateral corneal LSCD." @default.
• W1975479312 created "2016-06-24" @default.
• W1975479312 creator A5000085949 @default.
• W1975479312 creator A5004274304 @default.
• W1975479312 creator A5050740846 @default.
• W1975479312 creator A5064408268 @default.
• W1975479312 creator A5065112879 @default.
• W1975479312 creator A5067388024 @default.
• W1975479312 creator A5073125498 @default.
• W1975479312 date "2012-03-13" @default.
• W1975479312 modified "2023-10-03" @default.
• W1975479312 title "Cultured Autologous Oral Mucosal Epithelial Cell Sheet (CAOMECS) Transplantation for the Treatment of Corneal Limbal Epithelial Stem Cell Deficiency" @default.
• W1975479312 cites W108491111 @default.
• W1975479312 cites W1487158340 @default.
• W1975479312 cites W164798711 @default.
• W1975479312 cites W167208729 @default.
• W1975479312 cites W1964228231 @default.
• W1975479312 cites W1968663547 @default.
• W1975479312 cites W1968760803 @default.
• W1975479312 cites W1968882420 @default.
• W1975479312 cites W1980780439 @default.
• W1975479312 cites W1988921528 @default.
• W1975479312 cites W1989339760 @default.
• W1975479312 cites W2005356516 @default.
• W1975479312 cites W2006594781 @default.
• W1975479312 cites W2007976366 @default.
• W1975479312 cites W2012502752 @default.
• W1975479312 cites W2030330654 @default.
• W1975479312 cites W2040061404 @default.
• W1975479312 cites W2063704576 @default.
• W1975479312 cites W2068385632 @default.
• W1975479312 cites W2069098103 @default.
• W1975479312 cites W2081490638 @default.
• W1975479312 cites W2085820087 @default.
• W1975479312 cites W2109967486 @default.
• W1975479312 cites W2118596455 @default.
• W1975479312 cites W2121062346 @default.
• W1975479312 cites W2123630792 @default.
• W1975479312 cites W2133674399 @default.
• W1975479312 cites W2148709863 @default.
• W1975479312 cites W2150951775 @default.
• W1975479312 cites W2162445884 @default.
• W1975479312 cites W24215811 @default.
• W1975479312 doi "https://doi.org/10.1167/iovs.11-7744" @default.
• W1975479312 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22064987" @default.
• W1975479312 hasPublicationYear "2012" @default.
• W1975479312 type Work @default.
• W1975479312 sameAs 1975479312 @default.
• W1975479312 citedByCount "147" @default.
• W1975479312 countsByYear W19754793122012 @default.
• W1975479312 countsByYear W19754793122013 @default.
• W1975479312 countsByYear W19754793122014 @default.
• W1975479312 countsByYear W19754793122015 @default.
• W1975479312 countsByYear W19754793122016 @default.
• W1975479312 countsByYear W19754793122017 @default.
• W1975479312 countsByYear W19754793122018 @default.
• W1975479312 countsByYear W19754793122019 @default.
• W1975479312 countsByYear W19754793122020 @default.
• W1975479312 countsByYear W19754793122021 @default.
• W1975479312 countsByYear W19754793122022 @default.
• W1975479312 countsByYear W19754793122023 @default.
• W1975479312 crossrefType "journal-article" @default.
• W1975479312 hasAuthorship W1975479312A5000085949 @default.
• W1975479312 hasAuthorship W1975479312A5004274304 @default.
• W1975479312 hasAuthorship W1975479312A5050740846 @default.
• W1975479312 hasAuthorship W1975479312A5064408268 @default.
• W1975479312 hasAuthorship W1975479312A5065112879 @default.
• W1975479312 hasAuthorship W1975479312A5067388024 @default.
• W1975479312 hasAuthorship W1975479312A5073125498 @default.
• W1975479312 hasBestOaLocation W19754793121 @default.
• W1975479312 hasConcept C118487528 @default.
• W1975479312 hasConcept C126322002 @default.
• W1975479312 hasConcept C141071460 @default.
• W1975479312 hasConcept C142724271 @default.
• W1975479312 hasConcept C197934379 @default.
• W1975479312 hasConcept C204232928 @default.
• W1975479312 hasConcept C2776882836 @default.
• W1975479312 hasConcept C2779257441 @default.
• W1975479312 hasConcept C2780686511 @default.
• W1975479312 hasConcept C28328180 @default.
• W1975479312 hasConcept C2911091166 @default.
• W1975479312 hasConcept C52124034 @default.
• W1975479312 hasConcept C529295009 @default.
• W1975479312 hasConcept C54355233 @default.
• W1975479312 hasConcept C71924100 @default.
• W1975479312 hasConcept C86803240 @default.
• W1975479312 hasConceptScore W1975479312C118487528 @default.
• W1975479312 hasConceptScore W1975479312C126322002 @default.
• W1975479312 hasConceptScore W1975479312C141071460 @default.
• W1975479312 hasConceptScore W1975479312C142724271 @default.
• W1975479312 hasConceptScore W1975479312C197934379 @default.
• W1975479312 hasConceptScore W1975479312C204232928 @default.
• W1975479312 hasConceptScore W1975479312C2776882836 @default.
• W1975479312 hasConceptScore W1975479312C2779257441 @default.
• W1975479312 hasConceptScore W1975479312C2780686511 @default.
• W1975479312 hasConceptScore W1975479312C28328180 @default.
• W1975479312 hasConceptScore W1975479312C2911091166 @default.
• W1975479312 hasConceptScore W1975479312C52124034 @default.

• next