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- W1975492746 abstract "γ-Secretase is a membrane-embedded proteolytic complex composed of presenilin and three other subunits. The γ-secretase complex generates the amyloid β-peptide of Alzheimer's disease but also plays important roles in normal physiology, especially in signaling from the Notch receptor. How this hydrolytic enzyme works in a hydrophobic environment is largely unanswered, but mutagenesis and chemical probes have offered insight. γ-Secretase is an important therapeutic target, although mechanism-based toxicity presents a serious obstacle. Agents that lower amyloid β-peptide production while leaving important normal functions of γ-secretase intact are promising therapeutic leads. Inhibition of Notch signaling by γ-secretase inhibitors, which is undesirable for the prevention or treatment of Alzheimer's disease, may be beneficial for the treatment of a variety of cancers." @default.
- W1975492746 created "2016-06-24" @default.
- W1975492746 creator A5070207434 @default.
- W1975492746 date "2009-04-01" @default.
- W1975492746 modified "2023-10-18" @default.
- W1975492746 title "γ-Secretase in biology and medicine" @default.
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- W1975492746 doi "https://doi.org/10.1016/j.semcdb.2008.12.011" @default.
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