FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1975502924> ?p ?o ?g. }

• W1975502924 endingPage "e0121483" @default.
• W1975502924 startingPage "e0121483" @default.
• W1975502924 abstract "Objective Regulators of G-protein signaling protein 2 (RGS2) play an irreplaceable role in the control of normal blood pressure (BP). One RGS2 (-391, C>G) genetic variation markedly changes its mRNA expression levels. This study explored the relationship between this genetic variation and the responses to antihypertensive drugs in Chinese patients with essential hypertension. Methods Genetic variations of RGS2 were successfully identified in 367 specimens using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) assays. All patients were treated with conventional doses of antihypertensives after a 2-week run-in period and followed-up according to our protocol. A general linear model multivariate analysis of variance (ANOVA) was used for the data analysis. Results A significant difference in the mean systolic BP change was observed between RGS2 (-391, C>G) CC/CG (n = 82) and GG (n = 38) genotype carriers (-13.6 vs. -19.9 mmHg, P = 0.043) who were treated with candesartan, irbesartan or imidapril at the end of 6 weeks. In addition, the patients’ BP responses to α,β-adrenergic receptor blockers exhibited an age-specific association with the RGS2 (-391, C>G) genetic variation at the end of 4 weeks. Conclusion The RGS2 (-391, C>G) genetic polymorphism may serve as a biomarker to predict a patient’s response to antihypertensive drug therapy, but future studies need to confirm this." @default.
• W1975502924 created "2016-06-24" @default.
• W1975502924 creator A5003642180 @default.
• W1975502924 creator A5006416068 @default.
• W1975502924 creator A5011207006 @default.
• W1975502924 creator A5023983138 @default.
• W1975502924 creator A5030894785 @default.
• W1975502924 creator A5040833482 @default.
• W1975502924 creator A5044812776 @default.
• W1975502924 creator A5049083016 @default.
• W1975502924 creator A5056986109 @default.
• W1975502924 creator A5063346114 @default.
• W1975502924 creator A5063548954 @default.
• W1975502924 creator A5073213377 @default.
• W1975502924 creator A5076154481 @default.
• W1975502924 creator A5091070290 @default.
• W1975502924 date "2015-04-07" @default.
• W1975502924 modified "2023-10-17" @default.
• W1975502924 title "The RGS2 (-391, C>G) Genetic Variation Correlates to Antihypertensive Drug Responses in Chinese Patients with Essential Hypertension" @default.
• W1975502924 cites W1483452749 @default.
• W1975502924 cites W1964126186 @default.
• W1975502924 cites W1968192373 @default.
• W1975502924 cites W1969513837 @default.
• W1975502924 cites W1975443071 @default.
• W1975502924 cites W1981731922 @default.
• W1975502924 cites W1984910438 @default.
• W1975502924 cites W1985500659 @default.
• W1975502924 cites W2011500206 @default.
• W1975502924 cites W2014108369 @default.
• W1975502924 cites W2033717464 @default.
• W1975502924 cites W2038312257 @default.
• W1975502924 cites W2046215972 @default.
• W1975502924 cites W2048117991 @default.
• W1975502924 cites W2055121137 @default.
• W1975502924 cites W2060744991 @default.
• W1975502924 cites W2063624979 @default.
• W1975502924 cites W2063740327 @default.
• W1975502924 cites W2076993018 @default.
• W1975502924 cites W2080814134 @default.
• W1975502924 cites W2087502638 @default.
• W1975502924 cites W2090313348 @default.
• W1975502924 cites W2112156641 @default.
• W1975502924 cites W2119133799 @default.
• W1975502924 cites W2126049681 @default.
• W1975502924 cites W2131374289 @default.
• W1975502924 cites W2138512207 @default.
• W1975502924 cites W2351638507 @default.
• W1975502924 doi "https://doi.org/10.1371/journal.pone.0121483" @default.
• W1975502924 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4388730" @default.
• W1975502924 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25849301" @default.
• W1975502924 hasPublicationYear "2015" @default.
• W1975502924 type Work @default.
• W1975502924 sameAs 1975502924 @default.
• W1975502924 citedByCount "9" @default.
• W1975502924 countsByYear W19755029242017 @default.
• W1975502924 countsByYear W19755029242019 @default.
• W1975502924 countsByYear W19755029242020 @default.
• W1975502924 countsByYear W19755029242021 @default.
• W1975502924 countsByYear W19755029242022 @default.
• W1975502924 countsByYear W19755029242023 @default.
• W1975502924 crossrefType "journal-article" @default.
• W1975502924 hasAuthorship W1975502924A5003642180 @default.
• W1975502924 hasAuthorship W1975502924A5006416068 @default.
• W1975502924 hasAuthorship W1975502924A5011207006 @default.
• W1975502924 hasAuthorship W1975502924A5023983138 @default.
• W1975502924 hasAuthorship W1975502924A5030894785 @default.
• W1975502924 hasAuthorship W1975502924A5040833482 @default.
• W1975502924 hasAuthorship W1975502924A5044812776 @default.
• W1975502924 hasAuthorship W1975502924A5049083016 @default.
• W1975502924 hasAuthorship W1975502924A5056986109 @default.
• W1975502924 hasAuthorship W1975502924A5063346114 @default.
• W1975502924 hasAuthorship W1975502924A5063548954 @default.
• W1975502924 hasAuthorship W1975502924A5073213377 @default.
• W1975502924 hasAuthorship W1975502924A5076154481 @default.
• W1975502924 hasAuthorship W1975502924A5091070290 @default.
• W1975502924 hasBestOaLocation W19755029241 @default.
• W1975502924 hasConcept C104317684 @default.
• W1975502924 hasConcept C126322002 @default.
• W1975502924 hasConcept C134018914 @default.
• W1975502924 hasConcept C135763542 @default.
• W1975502924 hasConcept C149737253 @default.
• W1975502924 hasConcept C153209595 @default.
• W1975502924 hasConcept C163181125 @default.
• W1975502924 hasConcept C170493617 @default.
• W1975502924 hasConcept C2777097880 @default.
• W1975502924 hasConcept C2780259554 @default.
• W1975502924 hasConcept C2908647359 @default.
• W1975502924 hasConcept C4963665 @default.
• W1975502924 hasConcept C54355233 @default.
• W1975502924 hasConcept C68873052 @default.
• W1975502924 hasConcept C71924100 @default.
• W1975502924 hasConcept C80631254 @default.
• W1975502924 hasConcept C84393581 @default.
• W1975502924 hasConcept C86803240 @default.
• W1975502924 hasConcept C98274493 @default.
• W1975502924 hasConcept C99454951 @default.
• W1975502924 hasConceptScore W1975502924C104317684 @default.
• W1975502924 hasConceptScore W1975502924C126322002 @default.

• next