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- W1975505901 abstract "In eukaryotes, the DNA replication checkpoint prevents entry into mitosis when DNA replication is incomplete and is crucial for maintaining genomic integrity. Much less is known about equivalent controls that operate during meiosis. Here, we show that a DNA replication checkpoint control operates during meiosis in fission yeast. The mitotic checkpoint Rad genes and the Cds1 protein kinase are required for the DNA replication checkpoint during meiosis, with Cds1 playing a more prominent role than it does during mitosis. When DNA replication is blocked, the checkpoint maintains Cdc2 tyrosine 15 phosphorylation keeping Cdc2 protein kinase activity low and preventing onset of meiosis I. Additionally, there is a second checkpoint acting during meiosis that is revealed if cells are prevented from maintaining Cdc2 tyrosine 15 phosphorylation when DNA replication is blocked. Such cells arrest with high Cdc2 protein kinase activity and separated spindle pole bodies, an arrest state similar to that observed in mitotic budding yeast cells when DNA replication is incomplete. This second checkpoint is meiosis specific and may reflect processes occurring only during meiosis such as increased recombination rates, an extended duration of nuclear division, or homolog chromosome pairing." @default.
- W1975505901 created "2016-06-24" @default.
- W1975505901 creator A5019124036 @default.
- W1975505901 creator A5076038052 @default.
- W1975505901 date "1999-10-01" @default.
- W1975505901 modified "2023-10-14" @default.
- W1975505901 title "Meiotic DNA replication checkpoint control in fission yeast" @default.
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- W1975505901 cites W1782847872 @default.
- W1975505901 cites W1872930092 @default.
- W1975505901 cites W1876289295 @default.
- W1975505901 cites W1938207098 @default.
- W1975505901 cites W1968096672 @default.
- W1975505901 cites W1969308341 @default.
- W1975505901 cites W1977286657 @default.
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- W1975505901 cites W1988876917 @default.
- W1975505901 cites W1994909028 @default.
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- W1975505901 cites W2004008931 @default.
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- W1975505901 cites W2024519986 @default.
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- W1975505901 cites W2027195059 @default.
- W1975505901 cites W2029825047 @default.
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- W1975505901 doi "https://doi.org/10.1101/gad.13.19.2581" @default.
- W1975505901 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/317071" @default.
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