Matches in SemOpenAlex for { <https://semopenalex.org/work/W1975512162> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W1975512162 endingPage "572" @default.
- W1975512162 startingPage "569" @default.
- W1975512162 abstract "Although amphetamine induces hyperactivity by releasing dopamine (DA), mice that lack alpha1b-adrenoceptors do not release DA in response to amphetamine and do not, therefore, exhibit locomotor supersensitivity to amphetamine. However, such mice reveal hyperlocomotion to p-chloroamphetamine (PCA). Because these alpha1b-adrenoceptor knockout mice have no alterations in the striatal densities of DA D1 or D2 receptors, the basis for any possible dopaminergic contribution to the PCA-induced hyperlocomotion to PCA is unclear. Therefore, because supersensitive animals are generally known to have a higher proportion of DA D2 receptors in the high-affinity state for DA D2(High), we investigated whether there was any change in the alpha1b-adrenoceptor knockout striata in the proportion of DA D2(High) receptors to determine whether there could be a DA-based contribution to the PCA-induced hyperlocomotion. We found that the proportion of D2(High) in the wild type striata was 23 +/- 3.3%, whereas that in the alpha1b-adrenoceptor knockout striata was 52 +/- 2.9%, an increase of 2.3-fold. This elevation agrees with other types of DA-supersensitive animal striata and could assist in eliciting a supersensitive response in these alpha1b-adrenoceptor knockout mice." @default.
- W1975512162 created "2016-06-24" @default.
- W1975512162 creator A5005802064 @default.
- W1975512162 creator A5005918414 @default.
- W1975512162 creator A5023291283 @default.
- W1975512162 creator A5030610308 @default.
- W1975512162 creator A5072867653 @default.
- W1975512162 date "2007-01-01" @default.
- W1975512162 modified "2023-10-18" @default.
- W1975512162 title "Elevated dopamine D2High receptors in α-1b-adrenoceptor knockout supersensitive mice" @default.
- W1975512162 cites W1992991774 @default.
- W1975512162 cites W1998454579 @default.
- W1975512162 cites W2007935614 @default.
- W1975512162 cites W2015538348 @default.
- W1975512162 cites W2017044204 @default.
- W1975512162 cites W2027698033 @default.
- W1975512162 cites W2039641058 @default.
- W1975512162 cites W2066278769 @default.
- W1975512162 cites W2074631079 @default.
- W1975512162 cites W2125685489 @default.
- W1975512162 cites W2128014576 @default.
- W1975512162 cites W2140365112 @default.
- W1975512162 cites W4317523924 @default.
- W1975512162 cites W4319293053 @default.
- W1975512162 doi "https://doi.org/10.1002/syn.20401" @default.
- W1975512162 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17447259" @default.
- W1975512162 hasPublicationYear "2007" @default.
- W1975512162 type Work @default.
- W1975512162 sameAs 1975512162 @default.
- W1975512162 citedByCount "8" @default.
- W1975512162 countsByYear W19755121622012 @default.
- W1975512162 countsByYear W19755121622013 @default.
- W1975512162 countsByYear W19755121622017 @default.
- W1975512162 crossrefType "journal-article" @default.
- W1975512162 hasAuthorship W1975512162A5005802064 @default.
- W1975512162 hasAuthorship W1975512162A5005918414 @default.
- W1975512162 hasAuthorship W1975512162A5023291283 @default.
- W1975512162 hasAuthorship W1975512162A5030610308 @default.
- W1975512162 hasAuthorship W1975512162A5072867653 @default.
- W1975512162 hasConcept C120069818 @default.
- W1975512162 hasConcept C126322002 @default.
- W1975512162 hasConcept C134018914 @default.
- W1975512162 hasConcept C137183658 @default.
- W1975512162 hasConcept C170493617 @default.
- W1975512162 hasConcept C182704531 @default.
- W1975512162 hasConcept C185592680 @default.
- W1975512162 hasConcept C2777193897 @default.
- W1975512162 hasConcept C40465926 @default.
- W1975512162 hasConcept C44208683 @default.
- W1975512162 hasConcept C513476851 @default.
- W1975512162 hasConcept C55493867 @default.
- W1975512162 hasConcept C71924100 @default.
- W1975512162 hasConcept C86803240 @default.
- W1975512162 hasConceptScore W1975512162C120069818 @default.
- W1975512162 hasConceptScore W1975512162C126322002 @default.
- W1975512162 hasConceptScore W1975512162C134018914 @default.
- W1975512162 hasConceptScore W1975512162C137183658 @default.
- W1975512162 hasConceptScore W1975512162C170493617 @default.
- W1975512162 hasConceptScore W1975512162C182704531 @default.
- W1975512162 hasConceptScore W1975512162C185592680 @default.
- W1975512162 hasConceptScore W1975512162C2777193897 @default.
- W1975512162 hasConceptScore W1975512162C40465926 @default.
- W1975512162 hasConceptScore W1975512162C44208683 @default.
- W1975512162 hasConceptScore W1975512162C513476851 @default.
- W1975512162 hasConceptScore W1975512162C55493867 @default.
- W1975512162 hasConceptScore W1975512162C71924100 @default.
- W1975512162 hasConceptScore W1975512162C86803240 @default.
- W1975512162 hasIssue "7" @default.
- W1975512162 hasLocation W19755121621 @default.
- W1975512162 hasLocation W19755121622 @default.
- W1975512162 hasOpenAccess W1975512162 @default.
- W1975512162 hasPrimaryLocation W19755121621 @default.
- W1975512162 hasRelatedWork W1984070948 @default.
- W1975512162 hasRelatedWork W1991025791 @default.
- W1975512162 hasRelatedWork W1996327177 @default.
- W1975512162 hasRelatedWork W2027573451 @default.
- W1975512162 hasRelatedWork W2052453588 @default.
- W1975512162 hasRelatedWork W2064918881 @default.
- W1975512162 hasRelatedWork W2162783545 @default.
- W1975512162 hasRelatedWork W2314633410 @default.
- W1975512162 hasRelatedWork W4224302975 @default.
- W1975512162 hasRelatedWork W4253878465 @default.
- W1975512162 hasVolume "61" @default.
- W1975512162 isParatext "false" @default.
- W1975512162 isRetracted "false" @default.
- W1975512162 magId "1975512162" @default.
- W1975512162 workType "article" @default.