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- W1975521881 abstract "We have reviewed here three sets of data concerning the integration of retroviral sequences in the mammalian genome: (i) our experimental localization of a number of proviruses integrated in isochores characterized by different GC levels; (ii) results from other laboratories on the localization of retroviral sequences in open chromatin regions and/or next to CpG islands; and (iii) our compositional analysis of genes located in the neighborhood of integrated retroviral sequences. The three sets of data have provided a very consistent picture in that a compartmentalized, isopycnic integration of expressed proviruses appears to be the rule ('isopycnic' refers to the compositional match between viral and host sequences around the integration site). The results reviewed here suggest that: (i) integration of proviral sequences is targeted initially towards 'open chromatin regions'; while these exist in both GC-rich and GC-poor isochores, the 'open chromatin regions' of GC-rich isochores are the main targets for integration of retroviral sequences because of their much greater abundance; (ii) isopycnicity is associated with stability of integration; indeed, even non-expressed integrated retroviral sequences tend to show an isopycnic localization in the genome; (iii) transcription of integrated viral sequences (like transcription of host genes) appears to be associated, as a rule, with an isopycnic localization, as indicated by transcribed sequences that show an isopycnic integration and act in trans; (iv) selection plays a role in the choice of specific sites within an isopycnic region; in exceptional cases [such as mouse mammary tumor virus (MMTV) activating GC-rich oncogenes], selection may override isopycnicity." @default.
- W1975521881 created "2016-06-24" @default.
- W1975521881 creator A5031327714 @default.
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- W1975521881 creator A5082239220 @default.
- W1975521881 creator A5083068771 @default.
- W1975521881 date "1998-11-01" @default.
- W1975521881 modified "2023-09-26" @default.
- W1975521881 title "The regional integration of retroviral sequences into the mosaic genomes of mammals" @default.
- W1975521881 cites W1480778538 @default.
- W1975521881 cites W1480780537 @default.
- W1975521881 cites W1486866697 @default.
- W1975521881 cites W1489242367 @default.
- W1975521881 cites W1498109352 @default.
- W1975521881 cites W1517513139 @default.
- W1975521881 cites W1518709728 @default.
- W1975521881 cites W1520448866 @default.
- W1975521881 cites W1534046579 @default.
- W1975521881 cites W1535270156 @default.
- W1975521881 cites W1541725736 @default.
- W1975521881 cites W1555503775 @default.
- W1975521881 cites W1567479921 @default.
- W1975521881 cites W1568089172 @default.
- W1975521881 cites W1568345766 @default.
- W1975521881 cites W1596625302 @default.
- W1975521881 cites W1600900798 @default.
- W1975521881 cites W1602472801 @default.
- W1975521881 cites W1631289850 @default.
- W1975521881 cites W1646625758 @default.
- W1975521881 cites W1681143022 @default.
- W1975521881 cites W1748806315 @default.
- W1975521881 cites W1759752688 @default.
- W1975521881 cites W1792768597 @default.
- W1975521881 cites W1810980547 @default.
- W1975521881 cites W1814546794 @default.
- W1975521881 cites W1835015853 @default.
- W1975521881 cites W1844361913 @default.
- W1975521881 cites W1855754726 @default.
- W1975521881 cites W1866853199 @default.
- W1975521881 cites W1904815093 @default.
- W1975521881 cites W1922661470 @default.
- W1975521881 cites W1940140896 @default.
- W1975521881 cites W1957101562 @default.
- W1975521881 cites W1957957805 @default.
- W1975521881 cites W1963602582 @default.
- W1975521881 cites W1964528687 @default.
- W1975521881 cites W1967042754 @default.
- W1975521881 cites W1971020922 @default.
- W1975521881 cites W1971797273 @default.
- W1975521881 cites W1973662257 @default.
- W1975521881 cites W1974005072 @default.
- W1975521881 cites W1975197866 @default.
- W1975521881 cites W1976190891 @default.
- W1975521881 cites W1977895957 @default.
- W1975521881 cites W1979745608 @default.
- W1975521881 cites W1980248545 @default.
- W1975521881 cites W1982786884 @default.
- W1975521881 cites W1983809085 @default.
- W1975521881 cites W1984383973 @default.
- W1975521881 cites W1986772099 @default.
- W1975521881 cites W1987600685 @default.
- W1975521881 cites W1988365075 @default.
- W1975521881 cites W1989564317 @default.
- W1975521881 cites W1992066230 @default.
- W1975521881 cites W1993863888 @default.
- W1975521881 cites W1996019798 @default.
- W1975521881 cites W1996628643 @default.
- W1975521881 cites W1998131878 @default.
- W1975521881 cites W2004712213 @default.
- W1975521881 cites W2008516671 @default.
- W1975521881 cites W2008666823 @default.
- W1975521881 cites W201050536 @default.
- W1975521881 cites W2013241878 @default.
- W1975521881 cites W2014994812 @default.
- W1975521881 cites W2017810086 @default.
- W1975521881 cites W2024668373 @default.
- W1975521881 cites W2025043241 @default.
- W1975521881 cites W2025203479 @default.
- W1975521881 cites W2025776317 @default.
- W1975521881 cites W2027075470 @default.
- W1975521881 cites W2029033124 @default.
- W1975521881 cites W2029393760 @default.
- W1975521881 cites W2030075380 @default.
- W1975521881 cites W2031324110 @default.
- W1975521881 cites W2031477808 @default.
- W1975521881 cites W2032402189 @default.
- W1975521881 cites W2033386361 @default.
- W1975521881 cites W2034351801 @default.
- W1975521881 cites W2037903080 @default.
- W1975521881 cites W2039313637 @default.
- W1975521881 cites W2040427208 @default.
- W1975521881 cites W2040730301 @default.
- W1975521881 cites W2041535934 @default.
- W1975521881 cites W2041677039 @default.
- W1975521881 cites W2042115404 @default.
- W1975521881 cites W2042131034 @default.
- W1975521881 cites W2046156407 @default.