FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1975533268> ?p ?o ?g. }

• W1975533268 endingPage "548" @default.
• W1975533268 startingPage "536" @default.
• W1975533268 abstract "We present here a first characterization of LUMA, an unique integral inner nuclear membrane (INM) protein. LUMA is a highly conserved protein even in some bacteria and shares a PFAM domain of unknown function with orthologs from many species. Assessing LUMA topology by using protease protection of membrane-inserted LUMA and antibody epitope accessibility assays reveals that LUMA contains four transmembrane domains and a large hydrophilic domain located between membrane spans 1 and 2. The large hydrophilic domain is exposed to the perinuclear space whereas both LUMA termini reside cyto- or nucleoplasmically. Nuclear envelope targeting of LUMA mainly depends on the membrane spans. LUMA's transmembrane domains also promote homooligomerization. LUMA binds A- and B-type lamins and depends on A-type lamins for its INM localization. Furthermore, it interacts with emerin. Both downregulation of LUMA and overexpression of dominant-negative acting LUMA fragments causes redistribution of emerin. We propose that LUMA functions as a tetraspanin-like membrane organizer and has the potential to contribute to the pathomechanism of dystrophic diseases, such as Emery-Dreifuss muscular dystrophy." @default.
• W1975533268 created "2016-06-24" @default.
• W1975533268 creator A5020475421 @default.
• W1975533268 creator A5068099600 @default.
• W1975533268 date "2008-02-15" @default.
• W1975533268 modified "2023-09-25" @default.
• W1975533268 title "LUMA interacts with emerin and influences its distribution at the inner nuclear membrane" @default.
• W1975533268 cites W1487741670 @default.
• W1975533268 cites W1501180970 @default.
• W1975533268 cites W1754359083 @default.
• W1975533268 cites W1826524642 @default.
• W1975533268 cites W1845088912 @default.
• W1975533268 cites W1888731578 @default.
• W1975533268 cites W1964952136 @default.
• W1975533268 cites W1974862758 @default.
• W1975533268 cites W1975304761 @default.
• W1975533268 cites W1980069790 @default.
• W1975533268 cites W1989388714 @default.
• W1975533268 cites W1993035758 @default.
• W1975533268 cites W1993222258 @default.
• W1975533268 cites W1994373739 @default.
• W1975533268 cites W2003111937 @default.
• W1975533268 cites W2008627600 @default.
• W1975533268 cites W2011649455 @default.
• W1975533268 cites W2012502527 @default.
• W1975533268 cites W2016619116 @default.
• W1975533268 cites W2020616174 @default.
• W1975533268 cites W2023313219 @default.
• W1975533268 cites W2027990332 @default.
• W1975533268 cites W2043485308 @default.
• W1975533268 cites W2045564536 @default.
• W1975533268 cites W2048386264 @default.
• W1975533268 cites W2049979242 @default.
• W1975533268 cites W2056204193 @default.
• W1975533268 cites W2057586125 @default.
• W1975533268 cites W2058162240 @default.
• W1975533268 cites W2062056287 @default.
• W1975533268 cites W2063186096 @default.
• W1975533268 cites W2067455339 @default.
• W1975533268 cites W2069370795 @default.
• W1975533268 cites W2072245143 @default.
• W1975533268 cites W207356251 @default.
• W1975533268 cites W2075276135 @default.
• W1975533268 cites W2079995076 @default.
• W1975533268 cites W2083441358 @default.
• W1975533268 cites W2089681960 @default.
• W1975533268 cites W2092153867 @default.
• W1975533268 cites W2100837269 @default.
• W1975533268 cites W2101108802 @default.
• W1975533268 cites W2102424043 @default.
• W1975533268 cites W2106357210 @default.
• W1975533268 cites W2118016880 @default.
• W1975533268 cites W2118059357 @default.
• W1975533268 cites W2118740910 @default.
• W1975533268 cites W2119208710 @default.
• W1975533268 cites W2119588652 @default.
• W1975533268 cites W2123299380 @default.
• W1975533268 cites W2131965976 @default.
• W1975533268 cites W2134166457 @default.
• W1975533268 cites W2136490523 @default.
• W1975533268 cites W2145488605 @default.
• W1975533268 cites W2147905210 @default.
• W1975533268 cites W2149225679 @default.
• W1975533268 cites W2151755793 @default.
• W1975533268 cites W2152328062 @default.
• W1975533268 cites W2154698046 @default.
• W1975533268 cites W2154841454 @default.
• W1975533268 cites W2159336227 @default.
• W1975533268 cites W2163504716 @default.
• W1975533268 cites W2171721764 @default.
• W1975533268 cites W2171828238 @default.
• W1975533268 cites W4210400672 @default.
• W1975533268 cites W4214677910 @default.
• W1975533268 doi "https://doi.org/10.1242/jcs.019281" @default.
• W1975533268 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18230648" @default.
• W1975533268 hasPublicationYear "2008" @default.
• W1975533268 type Work @default.
• W1975533268 sameAs 1975533268 @default.
• W1975533268 citedByCount "77" @default.
• W1975533268 countsByYear W19755332682012 @default.
• W1975533268 countsByYear W19755332682013 @default.
• W1975533268 countsByYear W19755332682014 @default.
• W1975533268 countsByYear W19755332682015 @default.
• W1975533268 countsByYear W19755332682016 @default.
• W1975533268 countsByYear W19755332682017 @default.
• W1975533268 countsByYear W19755332682018 @default.
• W1975533268 countsByYear W19755332682019 @default.
• W1975533268 countsByYear W19755332682020 @default.
• W1975533268 countsByYear W19755332682021 @default.
• W1975533268 countsByYear W19755332682022 @default.
• W1975533268 countsByYear W19755332682023 @default.
• W1975533268 crossrefType "journal-article" @default.
• W1975533268 hasAuthorship W1975533268A5020475421 @default.
• W1975533268 hasAuthorship W1975533268A5068099600 @default.
• W1975533268 hasBestOaLocation W19755332681 @default.
• W1975533268 hasConcept C104317684 @default.
• W1975533268 hasConcept C118892022 @default.
• W1975533268 hasConcept C144647389 @default.

• next