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• W1975534819 endingPage "941" @default.
• W1975534819 startingPage "930" @default.
• W1975534819 abstract "Proinflammatory mediators such as tumor necrosis factor-alpha (TNF) have been implicated in the pathophysiology in a number of acute disease states. Tumor necrosis factor-alpha can contribute to cell death, apoptosis, and organ dysfunction. Tumor necrosis factor-alpha can be generated with sepsis or ischemia-reperfusion by activation of cell mitogen-activated protein kinases and nuclear factor kappa B, leading to TNF production. A number of strategies to modulate TNF have been recently explored, including factors directed toward mitogen-activated protein kinases, TNF transcription, anti-inflammatory ligands, heat shock proteins, and TNF-binding proteins. However, TNF may also play an important role in the adaptive response to injury and inflammation. Control of the deleterious effects of TNF and other proinflammatory cytokines represents a realistic goal for clinical emergency medicine. The purpose of this article is to provide a background of relevance to emergency medicine academicians on the production and regulation of TNF, the acute effects of TNF on pathophysiology, and the rationale for therapeutic interventions directed toward TNF and the clinical experience with these strategies." @default.
• W1975534819 created "2016-06-24" @default.
• W1975534819 creator A5004545352 @default.
• W1975534819 creator A5030814837 @default.
• W1975534819 creator A5040255031 @default.
• W1975534819 creator A5087253902 @default.
• W1975534819 date "2000-08-01" @default.
• W1975534819 modified "2023-10-17" @default.
• W1975534819 title "Bench to Bedside Tumor Necrosis Factor-alpha: From Inflammation to Resuscitation" @default.
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