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- W1975543265 abstract "Calcific degeneration is the main cause of failure of glutaraldehyde-treated xenograft heart valve substitutes implanted in humans. Coupling of heparin through an intermediate surface-bound substrate containing amino groups showed complete prevention of calcification of glutaraldehyde-treated porcine pericardium implanted subdermally in weanling rats for 5 months (heparin bonded pericardium: calcium, 0.625 ± 0.24 mg g−1; glutaraldehyde-only-treated pericardium: calcium, 228.32 ± 37.39 mg g−1; P < 0.0001). Conceivably, inactivation of unpaired aldehyde moieties present in bioprostheses after exposure to glutaraldehyde by amino compounds followed by blocking the potential binding sites of the graft with a surface modifying agent like heparin would be the key steps in the prevention of calcification and degeneration of glutaraldehyde-treated biological tissue grafts." @default.
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- W1975543265 date "1997-08-01" @default.
- W1975543265 modified "2023-09-26" @default.
- W1975543265 title "Heparin in calcification prevention of porcine pericardial bioprostheses" @default.
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- W1975543265 doi "https://doi.org/10.1016/s0142-9612(97)00033-1" @default.
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