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Matches in SemOpenAlex for { <https://semopenalex.org/work/W1975547444> ?p ?o ?g. }

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• W1975547444 abstract "Mono- and disaccharide-containing glycopolymers were synthesized by cyanoxyl-mediated polymerization of acrylamide with acrylate-derivatized mono- and disaccharides. We demonstrate that a glycopolymer bearing pendant, fully sulfated lactose units effectively replaces heparin and heparan sulfate as a molecular chaperone for fibroblast growth factor-2 (FGF-2). Specifically, a compound was identified that protects FGF-2 from proteolytic, acid, and heat-induced degradation, while selectively promoting growth factor and receptor dimerization. Significantly, the capacity of this heparin-mimic to promote an FGF-2 specific proliferative cell response was confirmed and suggests potential applications for this compound and related derivatives in areas related to therapeutic angiogenesis." @default.
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• W1975547444 date "2004-01-01" @default.
• W1975547444 modified "2023-10-16" @default.
• W1975547444 title "A Glycopolymer Chaperone for Fibroblast Growth Factor-2" @default.
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• W1975547444 doi "https://doi.org/10.1021/bc034138t" @default.
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