FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1975548302> ?p ?o ?g. }

• W1975548302 endingPage "839" @default.
• W1975548302 startingPage "833" @default.
• W1975548302 abstract "Using atomic absorption spectrum analysis, we found iron levels in exudates from chronic wounds to be significantly increased (3.71 +/- 1.56 micromol per g protein) compared to wound fluids from acute wounds derived from blister fluids (1.15 +/- 0.62 micromol per g protein, p < 0.02), drainage fluids of acute wounds (0.87 +/- 0.34 micromol per g protein, p < 0.002), and pooled human plasma of 50 volunteers (0.42 micromol per g protein). Increased free iron and an increase in reactive oxygen species released from neutrophils represent pathogenic key steps that --via the Fenton reaction - are thought to be responsible for the persistent inflammation, increased connective tissue degradation, and lipid peroxidation contributing to the prooxidant hostile microenvironment of chronic venous leg ulcers. We herein designed a selective pick-up dressing for iron ions by covalently binding deferoxamine to cellulose. No leakage occurred following gamma sterilization of the dressing and, more importantly, the deferoxamine-coupled cellulose dressing retained its iron complexing properties sufficient to reduce iron levels found in chronic venous ulcers to levels comparable to those found in acute wounds. In order to study the functionality of the dressing, human dermal fibroblasts were exposed to a Fenton reaction mimicking combination of 220 microM Fe(III) citrate and 1 mM ascorbate resulting in a 4-fold induction of matrix-degrading metalloproteinase 1 as determined by a matrix-degrading metalloproteinase 1 specific enzyme-linked immunosorbent assay. This induction was completely suppressed by dissolved deferoxamine at a concentration of 220 microM or by an equimolar amount of deferoxamine immobilized to cellulose. In addition, the Fe(III) citrate and ascorbate driven Fenton reaction resulted in an 8-fold increase in malondialdehyde, the major product of lipid peroxidation, as determined by high pressure liquid chromatography. This increase in malondialdehyde levels could be significantly reduced in the presence of the selective pick-up dressing coupled with deferoxamine suggesting that the deferoxamine dressing, in fact, prevents the development of a damaging prooxidant microenvironment and also protects from unfavorable consequences like matrix-degrading metalloproteinase 1 and lipid peroxide induction." @default.
• W1975548302 created "2016-06-24" @default.
• W1975548302 creator A5000209759 @default.
• W1975548302 creator A5003728992 @default.
• W1975548302 creator A5005215860 @default.
• W1975548302 creator A5011060521 @default.
• W1975548302 creator A5020036117 @default.
• W1975548302 creator A5032431700 @default.
• W1975548302 creator A5037235635 @default.
• W1975548302 creator A5039378924 @default.
• W1975548302 creator A5040524523 @default.
• W1975548302 creator A5042121912 @default.
• W1975548302 creator A5086247814 @default.
• W1975548302 date "2001-06-01" @default.
• W1975548302 modified "2023-10-03" @default.
• W1975548302 title "Selective Pick-Up of Increased Iron by Deferoxamine-Coupled Cellulose Abrogates the Iron-Driven Induction of Matrix-Degrading Metalloproteinase 1 and Lipid Peroxidation in Human Dermal Fibroblasts In Vitro: A New Dressing Concept" @default.
• W1975548302 cites W1457027874 @default.
• W1975548302 cites W1970955409 @default.
• W1975548302 cites W1975577170 @default.
• W1975548302 cites W1987918927 @default.
• W1975548302 cites W1990935670 @default.
• W1975548302 cites W1995349950 @default.
• W1975548302 cites W1996564102 @default.
• W1975548302 cites W2004127276 @default.
• W1975548302 cites W2011798768 @default.
• W1975548302 cites W2026847793 @default.
• W1975548302 cites W2033667314 @default.
• W1975548302 cites W2036246700 @default.
• W1975548302 cites W2037749245 @default.
• W1975548302 cites W2042396998 @default.
• W1975548302 cites W2046601332 @default.
• W1975548302 cites W2057055923 @default.
• W1975548302 cites W2059960043 @default.
• W1975548302 cites W2063540209 @default.
• W1975548302 cites W2075139730 @default.
• W1975548302 cites W2081642673 @default.
• W1975548302 cites W2082271643 @default.
• W1975548302 cites W2090125712 @default.
• W1975548302 cites W2090946357 @default.
• W1975548302 cites W2092767159 @default.
• W1975548302 cites W2093258500 @default.
• W1975548302 cites W2096385801 @default.
• W1975548302 cites W2106499996 @default.
• W1975548302 cites W2114443210 @default.
• W1975548302 cites W2120520218 @default.
• W1975548302 cites W2124333911 @default.
• W1975548302 cites W2284280435 @default.
• W1975548302 cites W2415856278 @default.
• W1975548302 cites W2603360489 @default.
• W1975548302 cites W4214589643 @default.
• W1975548302 cites W4293247451 @default.
• W1975548302 cites W4318750735 @default.
• W1975548302 cites W4379136709 @default.
• W1975548302 cites W582869841 @default.
• W1975548302 doi "https://doi.org/10.1046/j.1523-1747.2001.01345.x" @default.
• W1975548302 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11407968" @default.
• W1975548302 hasPublicationYear "2001" @default.
• W1975548302 type Work @default.
• W1975548302 sameAs 1975548302 @default.
• W1975548302 citedByCount "97" @default.
• W1975548302 countsByYear W19755483022012 @default.
• W1975548302 countsByYear W19755483022013 @default.
• W1975548302 countsByYear W19755483022014 @default.
• W1975548302 countsByYear W19755483022015 @default.
• W1975548302 countsByYear W19755483022016 @default.
• W1975548302 countsByYear W19755483022017 @default.
• W1975548302 countsByYear W19755483022018 @default.
• W1975548302 countsByYear W19755483022019 @default.
• W1975548302 countsByYear W19755483022020 @default.
• W1975548302 countsByYear W19755483022021 @default.
• W1975548302 countsByYear W19755483022022 @default.
• W1975548302 countsByYear W19755483022023 @default.
• W1975548302 crossrefType "journal-article" @default.
• W1975548302 hasAuthorship W1975548302A5000209759 @default.
• W1975548302 hasAuthorship W1975548302A5003728992 @default.
• W1975548302 hasAuthorship W1975548302A5005215860 @default.
• W1975548302 hasAuthorship W1975548302A5011060521 @default.
• W1975548302 hasAuthorship W1975548302A5020036117 @default.
• W1975548302 hasAuthorship W1975548302A5032431700 @default.
• W1975548302 hasAuthorship W1975548302A5037235635 @default.
• W1975548302 hasAuthorship W1975548302A5039378924 @default.
• W1975548302 hasAuthorship W1975548302A5040524523 @default.
• W1975548302 hasAuthorship W1975548302A5042121912 @default.
• W1975548302 hasAuthorship W1975548302A5086247814 @default.
• W1975548302 hasBestOaLocation W19755483021 @default.
• W1975548302 hasConcept C109523444 @default.
• W1975548302 hasConcept C185592680 @default.
• W1975548302 hasConcept C2776151105 @default.
• W1975548302 hasConcept C2776672577 @default.
• W1975548302 hasConcept C2779251873 @default.
• W1975548302 hasConcept C2780829032 @default.
• W1975548302 hasConcept C55493867 @default.
• W1975548302 hasConcept C71924100 @default.
• W1975548302 hasConcept C98274493 @default.
• W1975548302 hasConceptScore W1975548302C109523444 @default.
• W1975548302 hasConceptScore W1975548302C185592680 @default.
• W1975548302 hasConceptScore W1975548302C2776151105 @default.
• W1975548302 hasConceptScore W1975548302C2776672577 @default.

• next