FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1975560094> ?p ?o ?g. }

• W1975560094 endingPage "175" @default.
• W1975560094 startingPage "167" @default.
• W1975560094 abstract "4-hydroxynonenal (HNE) is a major aldehydic product of lipid peroxidation known to exert a multitude of biological, cytotoxic, and signal effects. Mammalian cells possess highly active pathways of HNE metabolism. The metabolic fate of HNE was investigated in various mammalian cells and organs such as hepatocytes, intestinal enterocytes, renal tubular cells, aortic and brain endothelial cells, synovial fibroblasts, neutrophils, thymocytes, heart, and tumor cells. The experiments were carried out at 37 degrees C at initial HNE concentrations between 1 microM--that means in the range of physiological and pathophysiologically relevant HNE levels--to 100 microM. In all cell types which were investigated, 90-95% of 100 microM HNE were degraded within 3 min of incubation. At 1 microM HNE the physiological blood serum level of about 0.1-0.2 microM was restored already after 10-30 s. As primary products of HNE in hepatocytes and other cell types the glutathione-HNE-1:1-conjugate, the hydroxynonenoic acid and the corresponding alcohol of HNE, the 1,4-dihydroxynonene, were identified. Furthermore, the beta-oxidation of hydroxynonenoic acid including the formation of water was demonstrated. The quantitative share of HNE binding to proteins was low with about 2-8% of total HNE consumption. The glycine-cysteine-HNE, cysteine-HNE adducts and the mercapturic acid from glutathione-HNE adduct were not formed in the most cell types, but in kidney cells and neutrophils. The rapid metabolism underlines the role of HNE degrading pathways in mammalian cells as important part of the secondary antioxidative defense mechanisms in order to protect proteins from modification by aldehydic lipid peroxidation products." @default.
• W1975560094 created "2016-06-24" @default.
• W1975560094 creator A5087695782 @default.
• W1975560094 creator A5091360482 @default.
• W1975560094 date "2003-08-01" @default.
• W1975560094 modified "2023-09-30" @default.
• W1975560094 title "Intracellular metabolism of 4-hydroxynonenal" @default.
• W1975560094 cites W1502736133 @default.
• W1975560094 cites W1522000230 @default.
• W1975560094 cites W1964613272 @default.
• W1975560094 cites W1969159151 @default.
• W1975560094 cites W1974539554 @default.
• W1975560094 cites W1985941345 @default.
• W1975560094 cites W1992294731 @default.
• W1975560094 cites W1992377755 @default.
• W1975560094 cites W1993986445 @default.
• W1975560094 cites W1998645487 @default.
• W1975560094 cites W2003422219 @default.
• W1975560094 cites W2008574812 @default.
• W1975560094 cites W2008962154 @default.
• W1975560094 cites W2016069834 @default.
• W1975560094 cites W2018214249 @default.
• W1975560094 cites W2018431876 @default.
• W1975560094 cites W2025433424 @default.
• W1975560094 cites W2027011315 @default.
• W1975560094 cites W2028161682 @default.
• W1975560094 cites W2039021289 @default.
• W1975560094 cites W2041766154 @default.
• W1975560094 cites W2041915244 @default.
• W1975560094 cites W2048966030 @default.
• W1975560094 cites W2057522312 @default.
• W1975560094 cites W2071794599 @default.
• W1975560094 cites W2075597041 @default.
• W1975560094 cites W2076671842 @default.
• W1975560094 cites W2077324620 @default.
• W1975560094 cites W2083771515 @default.
• W1975560094 cites W2087907333 @default.
• W1975560094 cites W2092343094 @default.
• W1975560094 cites W2128121467 @default.
• W1975560094 cites W2153235080 @default.
• W1975560094 cites W2171623445 @default.
• W1975560094 cites W2182857162 @default.
• W1975560094 cites W2415974759 @default.
• W1975560094 cites W76102735 @default.
• W1975560094 doi "https://doi.org/10.1016/s0098-2997(03)00011-6" @default.
• W1975560094 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12892994" @default.
• W1975560094 hasPublicationYear "2003" @default.
• W1975560094 type Work @default.
• W1975560094 sameAs 1975560094 @default.
• W1975560094 citedByCount "186" @default.
• W1975560094 countsByYear W19755600942012 @default.
• W1975560094 countsByYear W19755600942013 @default.
• W1975560094 countsByYear W19755600942014 @default.
• W1975560094 countsByYear W19755600942015 @default.
• W1975560094 countsByYear W19755600942016 @default.
• W1975560094 countsByYear W19755600942017 @default.
• W1975560094 countsByYear W19755600942018 @default.
• W1975560094 countsByYear W19755600942019 @default.
• W1975560094 countsByYear W19755600942020 @default.
• W1975560094 countsByYear W19755600942021 @default.
• W1975560094 countsByYear W19755600942022 @default.
• W1975560094 countsByYear W19755600942023 @default.
• W1975560094 crossrefType "journal-article" @default.
• W1975560094 hasAuthorship W1975560094A5087695782 @default.
• W1975560094 hasAuthorship W1975560094A5091360482 @default.
• W1975560094 hasConcept C181199279 @default.
• W1975560094 hasConcept C185592680 @default.
• W1975560094 hasConcept C2776151105 @default.
• W1975560094 hasConcept C2779201268 @default.
• W1975560094 hasConcept C2779308327 @default.
• W1975560094 hasConcept C2780829032 @default.
• W1975560094 hasConcept C4733338 @default.
• W1975560094 hasConcept C538909803 @default.
• W1975560094 hasConcept C55493867 @default.
• W1975560094 hasConcept C62231903 @default.
• W1975560094 hasConcept C79879829 @default.
• W1975560094 hasConceptScore W1975560094C181199279 @default.
• W1975560094 hasConceptScore W1975560094C185592680 @default.
• W1975560094 hasConceptScore W1975560094C2776151105 @default.
• W1975560094 hasConceptScore W1975560094C2779201268 @default.
• W1975560094 hasConceptScore W1975560094C2779308327 @default.
• W1975560094 hasConceptScore W1975560094C2780829032 @default.
• W1975560094 hasConceptScore W1975560094C4733338 @default.
• W1975560094 hasConceptScore W1975560094C538909803 @default.
• W1975560094 hasConceptScore W1975560094C55493867 @default.
• W1975560094 hasConceptScore W1975560094C62231903 @default.
• W1975560094 hasConceptScore W1975560094C79879829 @default.
• W1975560094 hasIssue "4-5" @default.
• W1975560094 hasLocation W19755600941 @default.
• W1975560094 hasLocation W19755600942 @default.
• W1975560094 hasOpenAccess W1975560094 @default.
• W1975560094 hasPrimaryLocation W19755600941 @default.
• W1975560094 hasRelatedWork W1502096965 @default.
• W1975560094 hasRelatedWork W1581167643 @default.
• W1975560094 hasRelatedWork W1968537115 @default.
• W1975560094 hasRelatedWork W1978522526 @default.
• W1975560094 hasRelatedWork W1983972257 @default.
• W1975560094 hasRelatedWork W1998645211 @default.

• next