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• W1975587038 abstract "SIR, David Kaplan (Immunol Today, 1984, 5, 130) discussed observations that insulin and perhaps other hormones are detectable as surface membrane anti- gens on the cells that secrete them. When considering the implication of these findings for the study of auto- immune disease he mentioned that the ability of anti-thyroglobulin (Tg) anti- body to block cell-mediated lysis of thyroid cell monolayers had been inter- preted as evidence that there are Tg determinants on the plasma membrane of thyroid cells. Our investigations of murine thyroiditis have given further evidence to support this view. In the past few years we have developed an in-vitro model of primary syngeneic sensitization on monolayers of thyroid epithelial cells (TEC) 1. We demonstrated that sensitization was directed against structures borne by syngeneic TEC only - more precisely Tg and class-II antigens of the major histocompatibility complex. We showed that specifically sensitized Lyt 1 + T lymphocytes could proliferate 2'3 and induce thyroiditis 4 when injected into intact syngeneic recipients and that this proliferation was under the same genetic controlS'6 as the induction of ex- perimental autoimmune thyroiditis by Tg and complete Freund's adjuvant. Very recent experiments suggest that Tg is the stimulating antigen for in-vitro sensitization but it does not act alone: the presence of syngeneic class-II anti- gens on the TEC, which act as antigen- presenting cells, is necessary for the induction of a proliferative response. However, syngeneic macrophages which have ingested Tg cannot induce the response. Syngeneic antigen, Tg in this instance, is thus presented in this in- vitro model of primary syngeneic sensi- tization only by the cell which synthe- sizes and bears it. We have also demonstrated that during in-vitro primary sensitization against TEC, lymphocytes were gener- ated which were cytotoxic only for syngeneic TEC, not other syngeneic 337 epithelial tissue or allogeneic TECI 7. The effector cell of the syngeneic cyto- toxicity is a Lyt 2 + T lymphocyte. Moreover, blocking experiments with monoclonal antibodies showed that this cytotoxicity was directed against class-I MHC antigens and Tg, this latter anti- gen being produced and carried on the membrane of the cultured TEC s. I~T] JEANNINE CHARREIRE JEAN SALAMERO INSERA4 U. 25, H6pital Necker, 75743 Paris Cedex 15, France" @default.
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• W1975587038 date "1984-12-01" @default.
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• W1975587038 title "Possible target antigens in autoimmune endocrine disease" @default.
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• W1975587038 doi "https://doi.org/10.1016/0167-5699(84)90068-9" @default.
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• W1975587038 hasPublicationYear "1984" @default.
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