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• W1975589080 abstract "We studied the effect of restraint stress on experimental allergic encephalomyelitis (EAE), a model for the human disease multiple sclerosis (MS), in Lewis rats. Rats were subjected to 12 h restraint stress for 3 consecutive nights from the first (day 1) or the eighth day (day 8) after sensitization with the antigen (guinea-pig spinal cord). All controlled rats exhibited clinical and histologic signs of EAE. The mean +/- SD of incubation time, clinical score (0-4) and histologic score (0-3) for this group were 12.8 +/- 1.0 days, 2.7 +/- 0.6, and 2.3 +/- 0.7, respectively. Restraint stress from day 8 significantly suppressed EAE: the mean +/- SD of incubation time, clinical score, and histologic score for this group were 17.2 +/- 2.2 days (p < 0.001), 1.8 +/- 1.3 (p < 0.05), and 1.5 +/- 0.9 (p < 0.02), respectively. Restraint stress from day 1 did not modify EAE. The findings suggest that stressful factors may exert an influence on the clinical course of MS." @default.
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• W1975589080 date "1994-01-01" @default.
• W1975589080 modified "2023-09-23" @default.
• W1975589080 title "Restraint stress suppresses experimental allergic encephalomyelitis in Lewis rats" @default.
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• W1975589080 doi "https://doi.org/10.1016/0361-9230(94)90180-5" @default.
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