FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1975590943> ?p ?o ?g. }

• W1975590943 endingPage "771" @default.
• W1975590943 startingPage "765" @default.
• W1975590943 abstract "This study was aimed to investigate the factors influencing long-term survival on patients with acute promyelocytic leukemia. Here, we present a single center retrospective study with long-term follow-up to explore the prognostic factors and a rationale of the using of ATRA, chemotherapy and As2O3 in the treatment of newly diagnosed APL patients. In total, 222 patients, 184 achieved complete remission (CR) with the CR rate of 82.88% and 22 patients died during early induction therapy with the early-death-rate of 10%. Total 171 newly diagnosed APL patients entering CR were retrospectively analyzed from November 1989 to December 2004,with a median follow-up of 36 months (6–185 months). Univariate and multivariate analysis of eight factors potentially influencing survival and prognosis were carried out with Log-Rank and Cox regression method, including sex, age, initial WBC count, the level of lactic dehydrogenase (LDH), first induction regimen, days from induction therapy to CR, post-remission therapy and the status of PML-RAR alpha fusion gene by reverse transcription-polymerase chain reaction (RT-PCR). The results showed that the estimated 5-year overall survival (OS) and relapse-free survival (RFS) were 80.9 ± 4.0 and 71.0 ± 4.0%, respectively. Univariate analyses showed that initial WBC count, first induction regimen, days from induction therapy to CR, post-remission therapy regimen and the status of PML-RAR alpha in remission were important prognostic factors for long-term survival. Multivariate study showed that only post-remission therapy regimen was associated with RFS and OS. It is concluded that the post-remission treatment combining ATRA, As2O3 and chemotherapy would significantly improve the long-term survival of APL patients achieving CR1." @default.
• W1975590943 created "2016-06-24" @default.
• W1975590943 creator A5000632526 @default.
• W1975590943 creator A5006292484 @default.
• W1975590943 creator A5008152072 @default.
• W1975590943 creator A5028552688 @default.
• W1975590943 creator A5032280848 @default.
• W1975590943 creator A5038389232 @default.
• W1975590943 creator A5053297135 @default.
• W1975590943 creator A5058927188 @default.
• W1975590943 creator A5061758333 @default.
• W1975590943 creator A5075285660 @default.
• W1975590943 creator A5077458512 @default.
• W1975590943 creator A5086214965 @default.
• W1975590943 date "2007-06-01" @default.
• W1975590943 modified "2023-09-27" @default.
• W1975590943 title "A survival study and prognostic factors analysis on acute promyelocytic leukemia at a single center" @default.
• W1975590943 cites W1515269506 @default.
• W1975590943 cites W1555554937 @default.
• W1975590943 cites W1790757523 @default.
• W1975590943 cites W1987484242 @default.
• W1975590943 cites W200159700 @default.
• W1975590943 cites W2043887757 @default.
• W1975590943 cites W2048623936 @default.
• W1975590943 cites W2076207516 @default.
• W1975590943 cites W2076426515 @default.
• W1975590943 cites W2100309315 @default.
• W1975590943 cites W2138630072 @default.
• W1975590943 cites W2145962537 @default.
• W1975590943 cites W2151347057 @default.
• W1975590943 cites W2184391500 @default.
• W1975590943 cites W2290016363 @default.
• W1975590943 cites W2334200141 @default.
• W1975590943 cites W2407345634 @default.
• W1975590943 cites W2414768692 @default.
• W1975590943 cites W2474307831 @default.
• W1975590943 cites W45100087 @default.
• W1975590943 doi "https://doi.org/10.1016/j.leukres.2006.07.028" @default.
• W1975590943 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17007927" @default.
• W1975590943 hasPublicationYear "2007" @default.
• W1975590943 type Work @default.
• W1975590943 sameAs 1975590943 @default.
• W1975590943 citedByCount "20" @default.
• W1975590943 countsByYear W19755909432012 @default.
• W1975590943 countsByYear W19755909432014 @default.
• W1975590943 countsByYear W19755909432015 @default.
• W1975590943 countsByYear W19755909432017 @default.
• W1975590943 countsByYear W19755909432019 @default.
• W1975590943 countsByYear W19755909432020 @default.
• W1975590943 countsByYear W19755909432021 @default.
• W1975590943 countsByYear W19755909432023 @default.
• W1975590943 crossrefType "journal-article" @default.
• W1975590943 hasAuthorship W1975590943A5000632526 @default.
• W1975590943 hasAuthorship W1975590943A5006292484 @default.
• W1975590943 hasAuthorship W1975590943A5008152072 @default.
• W1975590943 hasAuthorship W1975590943A5028552688 @default.
• W1975590943 hasAuthorship W1975590943A5032280848 @default.
• W1975590943 hasAuthorship W1975590943A5038389232 @default.
• W1975590943 hasAuthorship W1975590943A5053297135 @default.
• W1975590943 hasAuthorship W1975590943A5058927188 @default.
• W1975590943 hasAuthorship W1975590943A5061758333 @default.
• W1975590943 hasAuthorship W1975590943A5075285660 @default.
• W1975590943 hasAuthorship W1975590943A5077458512 @default.
• W1975590943 hasAuthorship W1975590943A5086214965 @default.
• W1975590943 hasConcept C104317684 @default.
• W1975590943 hasConcept C10515644 @default.
• W1975590943 hasConcept C126322002 @default.
• W1975590943 hasConcept C141071460 @default.
• W1975590943 hasConcept C143998085 @default.
• W1975590943 hasConcept C144301174 @default.
• W1975590943 hasConcept C167135981 @default.
• W1975590943 hasConcept C2776601000 @default.
• W1975590943 hasConcept C2776611710 @default.
• W1975590943 hasConcept C2776694085 @default.
• W1975590943 hasConcept C2780073493 @default.
• W1975590943 hasConcept C2781121885 @default.
• W1975590943 hasConcept C2781413609 @default.
• W1975590943 hasConcept C38180746 @default.
• W1975590943 hasConcept C50382708 @default.
• W1975590943 hasConcept C55493867 @default.
• W1975590943 hasConcept C71924100 @default.
• W1975590943 hasConcept C86803240 @default.
• W1975590943 hasConcept C90924648 @default.
• W1975590943 hasConceptScore W1975590943C104317684 @default.
• W1975590943 hasConceptScore W1975590943C10515644 @default.
• W1975590943 hasConceptScore W1975590943C126322002 @default.
• W1975590943 hasConceptScore W1975590943C141071460 @default.
• W1975590943 hasConceptScore W1975590943C143998085 @default.
• W1975590943 hasConceptScore W1975590943C144301174 @default.
• W1975590943 hasConceptScore W1975590943C167135981 @default.
• W1975590943 hasConceptScore W1975590943C2776601000 @default.
• W1975590943 hasConceptScore W1975590943C2776611710 @default.
• W1975590943 hasConceptScore W1975590943C2776694085 @default.
• W1975590943 hasConceptScore W1975590943C2780073493 @default.
• W1975590943 hasConceptScore W1975590943C2781121885 @default.
• W1975590943 hasConceptScore W1975590943C2781413609 @default.
• W1975590943 hasConceptScore W1975590943C38180746 @default.
• W1975590943 hasConceptScore W1975590943C50382708 @default.

• next